About: Adrian Thrasher

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About: Adrian Thrasher Goto Sponge NotDistinct Permalink

An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

British immunologist

Attributes	Values
rdf:type	Item
description	Forscher (de) investigador (es) chercheur (fr) дослідник (uk) United Kingdom karimba ŋun nyɛ doo (dag) 研究者 (zh) հետազոտող (hy) British immunologist (en) onderzoeker (nl)
rdfs:label	Adrian J Thrasher (es) Adrian J Thrasher (nl) Adrian J Thrasher (sl) Adrian J Thrasher (ast) Adrian Thrasher (en)
skos:prefLabel	Adrian J Thrasher (es) Adrian J Thrasher (nl) Adrian J Thrasher (sl) Adrian J Thrasher (ast) Adrian Thrasher (en)
name	Adrian J Thrasher (es) Adrian J Thrasher (nl) Adrian J Thrasher (sl) Adrian J Thrasher (ast) Adrian Thrasher (en)
given name	wds:Q60318865-5FE1B48E-3EF0-4D5F-A692-EA1AED57EA30
given name	Adrian
instance of	wds:Q60318865-760F0109-20E9-4936-A943-50005CBBCCFC
instance of	Homo sapiens
award received	wds:Q60318865-345430CB-C329-4D98-9F59-C15E7A2E91E5 wds:Q60318865-5965F594-33E6-4437-A750-3AF03DADBEAD wds:Q60318865-AD5EE5BD-5739-4F45-A1C6-C8037C7EF593 wds:Q60318865-DD845FA6-B48C-4C74-B219-982CF4638872 wds:Q60318865-E5786D11-0580-45C3-9A86-06F3CA84C5BB
award received	Fellow of the Royal Society of Biology Fellow of the Royal College of Physicians of London Fellow of the Academy of Medical Sciences Fellow of the Royal College of Pathologists Fellow of the Royal College of Paediatrics and Child Health
ResearchGate profile ID	wds:Q60318865-012db005-498e-dd30-f689-8d39019e4503
ResearchGate profile ID	Adrian_Thrasher
skos:altLabel	Adrian J Thrasher (en) Adrian James Thrasher (en)
occupation	wds:Q60318865-09A4A0CD-86F5-4FC1-984B-65C0B0DA0DCC wds:Q60318865-D13A3DA1-0E5E-4CF0-BFFD-00B599D1EF88
employer	wds:Q60318865-BC2B1411-8E9F-4B7C-8203-3179705B52FF
sex or gender	wds:Q60318865-21383ef1-4583-7eb4-6d1e-552cf3f7d0e2
country of citizenship	wds:Q60318865-CA4E569C-F4DB-4AF1-BA13-0CDC0FF7BA77
Who's Who UK ID	wds:Q60318865-b8f966d0-4397-517e-2239-63af5c8839ed
academic degree	wds:Q60318865-4037BC83-4881-4851-9A1E-7F0ABFCA35C0
date of birth	wds:Q60318865-C237780F-C79D-4F1A-8A79-CF459841FB3D
family name	wds:Q60318865-C25C96E5-392D-4856-A2CF-19B6A422C070
official website	wds:Q60318865-D1EF18E8-E854-411B-BA21-E4A495E4FD35
occupation	university teacher immunologist
employer	University College London
sex or gender	male
country of citizenship	United Kingdom
Who's Who UK ID	U249368
academic degree	Doctor of Philosophy
date of birth	1962-05-27 00:00:00Z (xsd:dateTime)
family name	Thrasher
official website	http://iris.ucl.ac.uk/iris/browse/profile?upi=ATHRA78
ORCID iD	wds:Q60318865-A6FB61B3-1B96-49D7-97E5-6CF792BD1FDB
ORCID iD	https://orcid.org/0000-0002-6097-6115
ORCID iD	0000-0002-6097-6115
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q60318865
is author of	Phosphorylation of WASp is a key regulator of activity and stability in vivo Brief report: self-organizing neuroepithelium from human pluripotent stem cells facilitates derivation of photoreceptors. The future of gene therapy Gene therapy for the Wiskott-Aldrich syndrome Role of WASP in cell polarity and podosome dynamics of myeloid cells WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorption The cytoplasm of living cells behaves as a poroelastic material Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming Human gamma delta T cells: a lymphoid lineage cell capable of professional phagocytosis Towards gene therapy for EBV-associated posttransplant lymphoma with genetically modified EBV-specific cytotoxic T cells Improvement of migratory defects in a murine model of Wiskott-Aldrich syndrome gene therapy B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response The leukocyte podosome Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice Effect of gene therapy on visual function in Leber's congenital amaurosis Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts. Cellular control of cortical actin nucleation A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency [correction of imunodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter Signal transducer and activator of transcription 5 tyrosine phosphorylation for the diagnosis and monitoring of patients with severe combined immunodeficiency Modelling of human Wiskott-Aldrich syndrome protein mutants in zebrafish larvae using in vivo live imaging Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration WASP: a key immunological multitasker

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