About: 2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels

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About: 2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels Goto Sponge NotDistinct Permalink

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scientific article published on 03 December 2018

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) im Januar 2018 veröffentlichter wissenschaftlicher Artikel (de) наукова стаття, опублікована у 2018 (uk) artículu científicu espublizáu n'avientu de 2018 (ast) scientific article published on 03 December 2018 (en)
publication date	wds:Q60047615-361A4534-98FF-4FBA-889C-5412A1552E5D
publication date	2018-12-03 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q60047615-4778BCDB-8E1E-459A-841C-666FB2104595
language of work or name	English
cites work	wds:Q60047615-19236F55-25BC-46C1-9270-19DA7CCA7317 wds:Q60047615-240ADC5E-F14A-4D2F-98DF-66391AC90D35 wds:Q60047615-2486DA91-AE1F-4C69-8CCB-17C124DBF242 wds:Q60047615-2A662242-DC5D-48C3-8E5A-A37A1EA7D06C wds:Q60047615-3023005D-17BC-4E32-B3FA-A0EACC4AA6C3 wds:Q60047615-3946F3F2-4B47-45E8-BD37-F1A9EF61C53F wds:Q60047615-3EDEBA5E-333D-49A5-A528-6F8F02AEE057 wds:Q60047615-49FF336C-4529-4C8F-B711-6B018AA3103A wds:Q60047615-4D7DFCD4-E013-4327-BF00-E1697D4CAA23 wds:Q60047615-4ED7D1F4-0D19-43C4-886E-A50CAA32F1F8 wds:Q60047615-537E9DF7-CAD0-4AB4-BF20-74909037CF05 wds:Q60047615-5A6A8B6F-D8C3-416F-A21D-48FF5283D901 wds:Q60047615-6044C832-F5B3-46E1-BD63-3D2F2B060E6C wds:Q60047615-62CA24D1-8C90-4889-B927-BDFB5501347A wds:Q60047615-771239E5-8AD5-4C0D-A725-ACC50C3DF6E9 wds:Q60047615-81C4FDA6-BBBF-48DA-A5FB-34ED93D798B5 wds:Q60047615-825D8C1B-A6F1-41CC-AA3A-A9ED7D32FC9A wds:Q60047615-8BEE0C7D-0B4F-4576-9372-377B8B8C07E2 wds:Q60047615-9C82DD43-6078-414A-9E4C-F926628DA978 wds:Q60047615-B8299987-3724-47F3-9813-3EE9153BCF63 wds:Q60047615-C325F1F0-4FA8-4A96-A4C1-1DC119387949 wds:Q60047615-CBA635AB-D51B-41E1-ADCC-3603B75C9A17 wds:Q60047615-D7BD5F90-85DE-46E8-BE48-7061F9207B6E wds:Q60047615-DB73058D-E090-4490-9D5B-A8F7C2890AD0 wds:Q60047615-E8EEC39C-447A-4B89-BE8D-011A5DD12265 wds:Q60047615-F5A5AA92-FD14-4C3A-8A43-4C939CA36FC3 wds:Q60047615-FB614335-B379-4BC6-AAAB-8C05B9F6827E
cites work	Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Small conductance calcium-activated potassium channels: from structure to function Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons. Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase Apamin Pharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1) SK channels and calmodulin Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (KCa 2) channels. Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs pH-dependent inhibition of K₂P3.1 prolongs atrial refractoriness in whole hearts Allosteric block of KCa2 channels by apamin Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria Selective activation of heteromeric SK channels contributes to action potential repolarization in mouse atrial myocytes Physiological Roles and Therapeutic Potential of Ca2+ Activated Potassium Channels in the Nervous System The small neurotoxin apamin blocks not only small conductance Ca2+ activated K+ channels (SK type) but also the voltage dependent Kv1.3 channel. Mitochondrial Ca2+-activated K+ channels and their role in cell life and death pathways. Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic blockers of the apamin-sensitive Ca(2+)-activated K(+) channel Effect of antiarrhythmic drugs on small conductance calcium - activated potassium channels. Small-conductance Ca2+-activated K+ channels: insights into their roles in cardiovascular disease. The Natural Flavone Acacetin Blocks Small Conductance Ca2+-Activated K+ Channels Stably Expressed in HEK 293 Cells Acetate recognition by 2,6-bis(2-benzimidazolyl)pyridine Mixed-ligand iridium(iii) complexes as photodynamic anticancer agents. New Disaccharide-Based Ether Lipids as SK3 Ion Channel Inhibitors.
author name string	wds:Q60047615-EEE767EB-523F-4DE0-94E2-9D0D2049458C
author name string	Ulrik S Sørensen
rdfs:label	2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels (en) 2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels (nl)
skos:prefLabel	2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels (en) 2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels (nl)
name	2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels (en) 2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels (nl)
author	wds:Q60047615-76CAB7E6-BD2E-40D5-96E8-19AAAE691F1F wds:Q60047615-9C1E1986-1917-4ECE-9C4E-EBCFAC255C73 wds:Q60047615-E05C1752-2752-467C-BF67-DBEE6AD52379
author	Bo Hjorth Bentzen Rafel Simó-Vicens Sofia Hammami Bomholtz
title	wds:Q60047615-1B24375B-53B4-4A85-8445-4B390332FD16
title	2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels (en)
page(s)	wds:Q60047615-ED8D2C63-3B92-4209-8014-DCEC4C0651C9
page(s)	1409
instance of	wds:Q60047615-238AF5D7-1470-4D50-82DB-D733524DB2FF
instance of	scholarly article
PubMed ID	wds:Q60047615-9E6940BD-5C05-4A97-B39E-0CB1063A5BE2
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30559671
PubMed ID	30559671
published in	wds:Q60047615-A24F1CDB-53CD-4F5E-9BA5-697B3BDF0278
published in	Frontiers in Pharmacology
volume	wds:Q60047615-5F066CC6-7E77-472D-A47A-DB7B10B94E17
volume	9
DOI	wds:Q60047615-33C39C00-15A6-4DCC-8A9C-180448D9740E
DOI	http://dx.doi.org/10.3389/FPHAR.2018.01409
DOI	10.3389/FPHAR.2018.01409
copyright license	wds:Q60047615-bb1897c9-184f-4c02-9248-984cedc84a0e
copyright status	wds:Q60047615-bc2ac8cb-5380-43ac-9d0c-2acda32fdd1b
copyright license	Creative Commons Attribution 4.0 International
copyright status	copyrighted
PMCID	wds:Q60047615-06200483-7B00-4D13-B518-9A413AC9C43A
PMCID	6287599

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