About: Paul M Kaye

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An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

researcher ORCID ID = 0000-0002-8796-4755

Attributes	Values
rdf:type	Item
description	forskare (sv) 연구원 (ko) 研究者 (ja) araştırmacı (tr) onderzoeker (nl) researcher ORCID ID = 0000-0002-8796-4755 (en)
rdfs:label	Paul M Kaye (en) Paul M Kaye (nl) Paul M Kaye (ast)
skos:prefLabel	Paul M Kaye (en) Paul M Kaye (nl) Paul M Kaye (ast)
name	Paul M Kaye (en) Paul M Kaye (nl) Paul M Kaye (ast)
Scopus author ID	wds:Q59697523-A0A7B8AC-3C2F-462C-A482-DF3AE2346D6A
Scopus author ID	7102603431
given name	wds:Q59697523-38902BBB-FFF9-4ABC-A148-D7662EA14A7E
given name	Paul
instance of	wds:Q59697523-B301B295-0433-478C-8563-A1B4B8C73909
instance of	Homo sapiens
award received	wds:Q59697523-2BF34F5B-751A-41C5-A914-E621F8EB382B wds:Q59697523-90209284-386E-4167-A780-1E34D2DE8378
award received	Fellow of the Academy of Medical Sciences Fellow of the Royal College of Pathologists
skos:altLabel	Paul Kaye (en) Paul Martin Kaye (en)
occupation	wds:Q59697523-FE8A48DC-794E-408F-8A04-45474C430F0C
employer	wds:Q59697523-7A9AAE0F-B49D-46A9-9900-E35A95769408
sex or gender	wds:Q59697523-C25F69A5-8025-4D33-87DA-D5F95558588F
Who's Who UK ID	wds:Q59697523-F33F23BB-B438-44FB-8906-35E34ADD844C
academic degree	wds:Q59697523-99D23FE7-6B88-465C-B7FA-4AE5A75E86B4
date of birth	wds:Q59697523-671FC8C1-B80F-4477-877B-65DDD1DE3126
educated at	wds:Q59697523-29F84364-BFAA-4963-98AC-A01C3C549B0F
family name	wds:Q59697523-F515BACC-AEFA-47EF-A1AE-4E7F143F6CC5
occupation	researcher
employer	London School of Hygiene & Tropical Medicine
sex or gender	male
Who's Who UK ID	U286520
academic degree	Doctor of Philosophy
date of birth	1959-10-20 00:00:00Z (xsd:dateTime)
educated at	University College London
family name	Kaye
ORCID iD	wds:Q59697523-A14627AF-7026-49D6-9A46-89E97AE2265B
Dimensions author ID	wds:Q59697523-E88C564D-83AC-4E76-829F-17F2795677A0
ORCID iD	https://orcid.org/0000-0002-8796-4755
ORCID iD	0000-0002-8796-4755
Dimensions author ID	01150516203.53
Gateway to Research person ID	wds:Q59697523-1DACCF48-B680-4B3A-96C4-7F47AB7012EE
Gateway to Research person ID	774D2A5D-D3BA-47D3-BBEF-1D7CFDCB9AB6
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q59697523
is author of	An in vivo analysis of cytokine production during Leishmania donovani infection in scid mice. Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate Stromal cell-derived CXCL12 and CCL8 cooperate to support increased development of regulatory dendritic cells following Leishmania infection Innate killing of Leishmania donovani by macrophages of the splenic marginal zone requires IRF-7 Immunotherapy with OX40L-Fc or anti-CTLA-4 enhances local tissue responses and killing of Leishmania donovani. IRF7 regulates TLR2-mediated activation of splenic CD11c(hi) dendritic cells. Comparative expression profiling of Leishmania: modulation in gene expression between species and in different host genetic backgrounds Leishmaniasis: complexity at the host-pathogen interface. Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses. Dendritic cells at the host-pathogen interface. Stromal-cell regulation of dendritic-cell differentiation and function IL-10-producing Th1 cells and disease progression are regulated by distinct CD11c⁺ cell populations during visceral leishmaniasis Stromal cells direct local differentiation of regulatory dendritic cells A role for tumor necrosis factor-alpha in remodeling the splenic marginal zone during Leishmania donovani infection. Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cells Neutralization of IL-12 demonstrates the existence of discrete organ-specific phases in the control of Leishmania donovani. Epitope cleavage by Leishmania endopeptidase(s) limits the efficiency of the exogenous pathway of major histocompatibility complex class I-associated antigen presentation. Altered course of visceral leishmaniasis in mice expressing transgenic I-E molecules Deficient expression of co-stimulatory molecules on Leishmania-infected macrophages. Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantum. Dynamic imaging of experimental Leishmania donovani-induced hepatic granulomas detects Kupffer cell-restricted antigen presentation to antigen-specific CD8 T cells The neurotrophic receptor Ntrk2 directs lymphoid tissue neovascularization during Leishmania donovani infection Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in mice Interferon regulatory factor 7 contributes to the control of Leishmania donovani in the mouse liver. Enhanced hematopoietic activity accompanies parasite expansion in the spleen and bone marrow of mice infected with Leishmania donovani Leishmania donovani-induced expression of signal regulatory protein alpha on Kupffer cells enhances hepatic invariant NKT-cell activation Compartment-specific remodeling of splenic micro-architecture during experimental visceral leishmaniasis. A Petri net model of granulomatous inflammation: implications for IL-10 mediated control of Leishmania donovani infection The immunopathology of experimental visceral leishmaniasis Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory function. A transcriptomic network identified in uninfected macrophages responding to inflammation controls intracellular pathogen survival. Immunomodulators: use in combined therapy against leishmaniasis Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria Single dose novel Salmonella vaccine enhances resistance against visceralizing L. major and L. donovani infection in susceptible BALB/c mice Therapeutic vaccination with recombinant adenovirus reduces splenic parasite burden in experimental visceral leishmaniasis. In vivo recognition of ovalbumin expressed by transgenic Leishmania is determined by its subcellular localization. Loss of dendritic cell migration and impaired resistance to Leishmania donovani infection in mice deficient in CCL19 and CCL21. Localization of marginal zone macrophages is regulated by C-C chemokine ligands 21/19. Post kala-azar dermal leishmaniasis: an unresolved mystery The role of dendritic cells in the induction and regulation of immunity to microbial infection. Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1β production following Toll-like receptor 2 stimulation in THP-1 monocytes Transgenic Leishmania and the immune response to infection Tissue cytokine responses in canine visceral leishmaniasis CD8+ T-cell priming regulated by cytokines of the innate immune system. Distinct roles for lymphotoxin-alpha and tumor necrosis factor in the control of Leishmania donovani infection. Dendritic cells matured by inflammation induce CD86-dependent priming of naive CD8+ T cells in the absence of their cognate peptide antigen. Antigens targeted to the Leishmania phagolysosome are processed for CD4+ T cell recognition.

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