About: Increased Level of Dihydrofolic Reductase in Leucocytes of Patients Treated with Amethopterin

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scientific article published in Nature

Attributes	Values
rdf:type	Item
description	artículu científicu (ast) wetenschappelijk artikel (nl) article publié dans la revue scientifique Nature (fr) scientific article published in Nature (en) im Jahr 1962 veröffentlichter wissenschaftlicher Artikel (de) наукова стаття, опублікована в Nature в січні 1962 (uk)
publication date	wds:Q59065413-9940D682-7118-485C-A197-357406560E8E
publication date	1962-01-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q59065413-9C2A0E95-39D6-4C87-984C-85AC48A4B362
language of work or name	English
exact match	wds:Q59065413-5439744A-730D-461A-A11C-5C343F9346E7
exact match	https://scigraph.springernature.com/pub.10.1038/193140a0
cites work	wds:Q59065413-3317B9AF-B388-4790-83B1-88A9DBB1C350 wds:Q59065413-6DB80B09-A450-4A00-BDBF-8C53439FF93A wds:Q59065413-C2B7A8D3-6D19-49AB-B6B2-A0DC14E6049D
cites work	Studies on the conversion of deoxyuridylic acid to thymidylic acid by a soluble extract from rat thymus On the mechanism of action of aminopterin Increased dihydrofolate reductase activity as a possible basis of drug resistance in leukaemia.
author name string	wds:Q59065413-1C01D1AB-3A18-4E70-9A7E-BB665027BAA6 wds:Q59065413-302FFBCD-1F79-429A-81FF-F2488B535BCD wds:Q59065413-34E49AFC-7659-4E39-9ABA-1D78731B449E wds:Q59065413-4D0A2A09-740B-4991-830B-B4D823B1A042 wds:Q59065413-542570B5-DBED-4277-9327-1A9A016AE35E wds:Q59065413-871D64B7-821D-46DF-BEC0-C576BF456B42 wds:Q59065413-DC25687F-2265-423A-81C9-68F6389E5532
author name string	M MEYER F M HUENNEKENS B W GABRIO J R BERTINO R SILBER A ALENTY D R DONOHUE
rdfs:label	Increased Level of Dihydrofolic Reductase in Leucocytes of Patients Treated with Amethopterin (en) Increased Level of Dihydrofolic Reductase in Leucocytes of Patients Treated with Amethopterin (nl)
skos:prefLabel	Increased Level of Dihydrofolic Reductase in Leucocytes of Patients Treated with Amethopterin (en) Increased Level of Dihydrofolic Reductase in Leucocytes of Patients Treated with Amethopterin (nl)
name	Increased Level of Dihydrofolic Reductase in Leucocytes of Patients Treated with Amethopterin (en) Increased Level of Dihydrofolic Reductase in Leucocytes of Patients Treated with Amethopterin (nl)
title	wds:Q59065413-E187121C-B1F8-4657-8294-6D4C9DDC61F9
title	Increased level of dihydrofolic reductase in leucocytes of patients treated with amethopterin (en)
page(s)	wds:Q59065413-29E6545C-AE0A-4161-9C09-557305330134
page(s)	140-142
instance of	wds:Q59065413-998791CE-A3E3-42BF-A8A7-826BF9341561
instance of	scholarly article
main subject	wds:Q59065413-FA113EC8-CED5-4A8D-9713-15BC8AABE7E7
main subject	wd:Q422232
PubMed ID	wds:Q59065413-E1737496-13F5-4C3F-89B6-EEC8F105F51B
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13868435
PubMed ID	13868435
published in	wds:Q59065413-792DF3A8-1A27-415A-8E4D-B69E9B667760
published in	Nature
issue	wds:Q59065413-6CB20CA0-15D2-49AD-A5AB-D7165612FFF0
volume	wds:Q59065413-9EF47EAF-255A-416A-BE5E-2D7D1603AB35
issue	4811
volume	193
DOI	wds:Q59065413-9EB9A846-F252-4D18-8AF8-B90F1A4C4D2B
DOI	http://dx.doi.org/10.1038/193140A0
DOI	10.1038/193140A0
Dimensions Publication ID	wds:Q59065413-6E1F75EA-3229-4CC2-BD03-C124EE7A0E75
Dimensions Publication ID	1038208110
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q59065413
is cites work of	Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression Inhibition of neutrophil chemotaxis in methotrexate-treated rheumatoid arthritis patients The clinical pharmacology of methotrexate.new applications of an old drug THE "INDUCTION" OF DIHYDROFOLIC REDUCTASE ACTIVITY IN LEUKOCYTES AND ERYTHROCYTES OF PATIENTS TREATED WITH AMETHOPTERIN STUDIES ON NORMAL AND LEUKEMIC LEUKOCYTES. IV. TETRAHYDROFOLATE-DEPENDENT ENZYME SYSTEMS AND DIHYDROFOLIC REDUCTASE Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment Species-specific differences in translational regulation of dihydrofolate reductase Regulation of human dihydrofolate reductase activity and expression Changes of molecular properties associated with the development of resistance against methotrexate in human lymphoblastoid cells Determinants of trimetrexate lethality in human colon cancer cells MECHANISMS OF RESISTANCE TO ANTICANCER AGENTS. The variability of individual tolerance to methotrexate in cancer patients Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: findings in a prospective, randomized, double-blind clinical trial in fifteen patients In search of dihydrofolate reductase Studies on dihydrofolate reductase related to the drug sensitivity of microbial and neoplastic cells [Effect and istribution of methotrexate in the human organism during leukemia treatment] Serum profiles of methotrexate after its administration in children with acute lymphoblastic leukaemia Sites of action of amethopterin: intrinsic and acquired drug resistance Targeting nuclear thymidylate biosynthesis Methotrexate: clinical pharmacology, current status and therapeutic guidelines Cytochemical demonstration of dihydrofolate reductase activity. [THE SIGNIFICANCE OF THE FOLIC ACID METABOLISM FOR THE NORMAL AND PATHOLOGICAL MATURATION OF BLOOD CELLS] Defective transport of aminopterin in relation to development of resistance in Yoshida sarcoma cells Dihydrofolate reductase activity and deoxynucleoside incorporation into DNA of human leukocytes.Relation to methotrexate administration A qualitative and quantitative cytochemical assay of dihydrofolate reductase in erythroid cells Translational modulation of proteins expressed from bicistronic vectors Tetrahydrofolate dehydrogenase in blood cells and in hematopoietic organs of different vertebrate species Action of intermediate doses of methotrexate on dihydrofolate reductase in malignant diseases Cytochemical Demonstration of Dihydrofolate Reductase in Leukaemia and Other Haematological Diseases
is cites work of	wds:Q38328306-878F8836-FCE3-4682-BD05-2A24D0770269 wds:Q41494448-2FEDA82E-05DC-4240-BF57-E813424F130E wds:Q74023929-5D17CB44-C722-4181-8967-1F9C6F1760F8 wds:Q33462590-5E31A8BF-1A7C-4025-9D7D-CA825176FE1A wds:Q33827935-1110F578-DE72-4CC5-A6DA-F7B58329F0E8 wds:Q34657210-B1D79803-3946-4ABC-BC2B-A10568E0C00B wds:Q39017134-5C9B7463-2E5D-494F-909D-01E1556CF1F0 wds:Q54619900-06591979-A118-48F6-9BFE-7A254255F6C0 wds:Q39716312-30229D55-9351-4EDA-B8F8-989D2C22947A

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