About: Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

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About: Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain Goto Sponge NotDistinct Permalink

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scientific article published in Nature

Attributes	Values
rdf:type	Item
description	artículu científicu (ast) wetenschappelijk artikel (nl) article publié dans la revue scientifique Nature (fr) scientific article published in Nature (en) im Oktober 1989 veröffentlichter wissenschaftlicher Artikel (de) наукова стаття, опублікована в Nature в жовтні 1989 (uk)
publication date	wds:Q59048439-8DA77B92-2E0F-45D9-AC90-145B2990A3E8
publication date	1989-10-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q59048439-843D8CF2-D78C-4973-A324-58AA2382E5EB
language of work or name	English
exact match	wds:Q59048439-0A15BB3A-8BF8-4988-BBA0-7FA5AC8A0FE9
exact match	https://scigraph.springernature.com/pub.10.1038/341651a0
cites work	wds:Q59048439-1C879A18-14DE-4793-B57B-067ACF662B20 wds:Q59048439-2720DAE6-EB01-43C5-B7F9-6C74FF7643F7 wds:Q59048439-3BB01D36-15AE-465C-91FC-209CCE016D3A wds:Q59048439-3C8996AB-5016-4A92-AC2F-666D0DB8B973 wds:Q59048439-3D949595-2746-442F-BC9F-D4D28EB87702 wds:Q59048439-446F0D9B-C8AD-46F1-A09F-963706BEBE2D wds:Q59048439-4DFF0913-22FF-432C-B9DD-67D590F46FA9 wds:Q59048439-5B5C2616-B5BC-4E25-82F2-43D7CC3AF6C2 wds:Q59048439-5D5211B7-C8DB-4D77-A04C-D39DECFFF840 wds:Q59048439-7A7C12A0-792D-411A-A96E-AD9A289E2080 wds:Q59048439-868CEBAF-6BA2-4196-8AFB-9046A09458CB wds:Q59048439-91265508-12EE-4B70-B503-5AEA524AE2E7 wds:Q59048439-95AFF38D-889E-4B45-9EF7-CD5B7EC12989 wds:Q59048439-A4BC1508-7BAD-4F8E-A652-4DD6D6F635E2 wds:Q59048439-B784E41A-CA26-438B-BD91-6616B38C3899 wds:Q59048439-BF093620-D7AE-413A-ABA8-61B91C7EC2E2 wds:Q59048439-C01B5F5E-CE86-4099-9DB1-10B204645339 wds:Q59048439-C698DEE4-4AFF-4C85-9A91-5D263EF9ECC2 wds:Q59048439-CC50AA2D-9B2C-4F9E-8115-1BDFFE04CE04 wds:Q59048439-CD742914-BB78-4286-8987-04A27B00F305 wds:Q59048439-DB78511A-C2D2-499F-9311-A592BB3B1D6C wds:Q59048439-DDBEA0B5-D6F3-41E0-9D35-73A97F717B8B wds:Q59048439-E1607F16-AD4B-4E75-A374-430A2AFFE101 wds:Q59048439-FC9EA612-858E-4D3D-8694-4E550F534830
cites work	Identification of a monoclonal antibody specific for a murine T3 polypeptide Positive and negative selection of an antigen receptor on T cells in transgenic mice. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen-Reactivity Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes Effective activation of resting mouse T lymphocytes by cross-linking submitogenic concentrations of the T cell antigen receptor with either Lyt-2 or L3T4 Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens T cell tolerance by clonal elimination in the thymus Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes. Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens* A T cell receptor V beta segment that imparts reactivity to a class II major histocompatibility complex product. Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes The T cell receptor V beta 6 domain imparts reactivity to the Mls-1a antigen Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking Differentiation of Ia-reactive CD8+ murine T cells does not require Ia engagement. Implications for the role of CD4 and CD8 accessory molecules in T cell differentiation Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens Preferential expression of the T-cell receptor Vβ3 gene by Mlsc reactive T cells
author name string	wds:Q59048439-12F6E521-0847-43AD-A977-1B915CF73F8D wds:Q59048439-5259E2C6-78C6-4B6F-8374-8A11B9FE47EB wds:Q59048439-6F282372-1B9C-4B7A-AFB0-1F7FCD3A6741
author name string	Singer A Samelson LE Hsi ED
rdfs:label	Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain (en) Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain (nl)
skos:prefLabel	Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain (en) Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain (nl)
name	Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain (en) Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain (nl)
author	wds:Q59048439-A0923046-2769-4FEA-9C95-2CF1DFB0F88A
author	Toshinori Nakayama
title	wds:Q59048439-EDC3D329-23BC-46BE-9E55-42E4A1149FC7
title	Intrathymic signalling in immature CD4+CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain (en)
page(s)	wds:Q59048439-88504F27-24AA-4DE8-897F-ED7475B99170
page(s)	651-654
instance of	wds:Q59048439-F4607ED0-6B3C-4D2C-AAC5-620C6C8695BD
instance of	scholarly article
main subject	wds:Q59048439-32FE23B1-9160-43BA-BD76-834ED38B1AF3 wds:Q59048439-AA70F1F6-BBAD-402A-9C58-770854634A86
main subject	phosphorylation thymocyte
PubMed ID	wds:Q59048439-720760D6-88FD-42AD-947D-E8DF35878417
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2477711
PubMed ID	2477711
published in	wds:Q59048439-97303588-D753-4FCF-AFE4-D58B5A6A4659
published in	Nature
issue	wds:Q59048439-D86B8999-D31B-4A2D-9D33-143AD2CB2B86
volume	wds:Q59048439-5C920DCC-F901-4448-BB15-FA1BFF6682C0
issue	6243
volume	341
number of pages	wds:Q59048439-0A39108B-42C9-4280-A96C-54F697908647
number of pages	4 (xsd:decimal)
DOI	wds:Q59048439-1076C654-71A8-41D9-9A08-417939637543
DOI	http://dx.doi.org/10.1038/341651A0
DOI	10.1038/341651A0
Dimensions Publication ID	wds:Q59048439-87FACCEC-15E5-4978-BA30-4976E15DBE8E

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