About: Identification and Characterization of Novel CFTR Potentiators

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scholarly article by Maarten Gees et al published 2018 in Frontiers in Pharmacology

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) im Januar 2018 veröffentlichter wissenschaftlicher Artikel (de) наукова стаття, опублікована у 2018 (uk) article scientifique publié en 2018 (fr) scholarly article by Maarten Gees et al published 2018 in Frontiers in Pharmacology (en)
publication date	wds:Q58707750-EB4E89D1-835D-451F-9D68-2B860E7CBB4A
publication date	2018-01-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q58707750-A28B2FF1-F5F5-4138-9EEA-098BD2CAE2CE
language of work or name	English
cites work	wds:Q58707750-2E63E6EE-BA68-40DC-9492-55D571C1F686 wds:Q58707750-46871547-7F5F-4986-8622-085526A05AC9 wds:Q58707750-551168AE-84E3-4C63-9F28-2ABCEAB31D4D wds:Q58707750-554229B2-B724-4CB5-8124-3DD3B4F782B6 wds:Q58707750-5DE00798-87CD-4D52-A6F6-076DC4C9E778 wds:Q58707750-696E9387-6DD9-4076-94F6-FB1131A58254 wds:Q58707750-71786A04-2506-4F30-8234-E1726D8F8C66 wds:Q58707750-8050ED5E-B7B4-426E-99CB-3979FAD0F4D3 wds:Q58707750-80C9B587-F276-4BDE-BF02-9247DC34898C wds:Q58707750-92D1FE8F-E8DC-436F-9F11-6E0B347CC008 wds:Q58707750-9EA7EEB0-1811-47D8-A0AB-C735539A750E wds:Q58707750-A699ED80-138E-495C-B23B-34E78703B311 wds:Q58707750-B2B24990-3623-445A-BC92-6B67AC58BB49 wds:Q58707750-C865B7EB-BD57-4DD5-ACAF-9042328DF0E8 wds:Q58707750-C8FAFA3F-EB26-419C-951E-5C79C44EFBC9 wds:Q58707750-CBE8EEE6-A211-43BB-B47A-C4A803C2E650 wds:Q58707750-D06CDDB9-5EB9-4E85-83CC-4D0B4A25803A wds:Q58707750-D5144B05-2A7A-45DC-AF3D-4D16DB447ED5 wds:Q58707750-D5582F45-F9C9-42A1-8559-CB0CB2ACA677 wds:Q58707750-D59E342C-A256-42D1-87B4-503817DA4D9E wds:Q58707750-EA05EE12-CA29-4C5A-8B7C-9D27F24A7927 wds:Q58707750-F523368D-D859-4C2E-8586-9628D4A42533 wds:Q58707750-FC7F791F-3685-43AF-90B7-97911667FB0A wds:Q58707750-FCF92979-61EF-4D47-AD60-5E3BD868EAD9
cites work	Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis A CFTR potentiator in patients with cystic fibrosis and the G551D mutation Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression. Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770 Well-differentiated human airway epithelial cell cultures. Cystic fibrosis: insight into CFTR pathophysiology and pharmacotherapy. Ivacaftor potentiation of multiple CFTR channels with gating mutations Rapid kinetic analysis of multichannel records by a simultaneous fit to all dwell-time histograms Lumacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR. Novel pharmacological strategies to treat cystic fibrosis. Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle Model of the cAMP activation of chloride transport by CFTR channel and the mechanism of potentiators The relative frequency of CFTR mutation classes in European patients with cystic fibrosis Potentiators of Defective ΔF508-CFTR Gating that Do Not Interfere with Corrector Action. Repairing mutated proteins--development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator On the mechanism of gating defects caused by the R117H mutation in cystic fibrosis transmembrane conductance regulator Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del. Mutation-specific downregulation of CFTR2 variants by gating potentiators. A common mechanism for CFTR potentiators. Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to Potentiation of ΔF508- and G551D-CFTR-Mediated Cl- Current by Novel Hydroxypyrazolines Synergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamino) Benzoate
author name string	wds:Q58707750-025C9B4C-AACD-4ED9-BEEE-EF8E5850D7E3 wds:Q58707750-18BB6D72-171A-436B-A6F2-CAC5BEC1E820 wds:Q58707750-1F111F89-EBF6-4C10-A6F6-91F05F233333 wds:Q58707750-2805CB04-530F-47DA-8812-97578F41E468 wds:Q58707750-2E6E8C91-E0A8-4C77-BF4F-A93E31C11F43 wds:Q58707750-4918294D-1A58-4EB4-AA76-9DF41F58F342 wds:Q58707750-5A9BD135-5EC4-4857-B951-D704350AA7DE wds:Q58707750-6BB349B5-AC5D-4CCA-B618-68195F6C44C0 wds:Q58707750-896EAF33-18A9-4500-87CE-A436209126E3 wds:Q58707750-934FF957-6BD3-435D-8343-C62F7B3299BE wds:Q58707750-9359B5B1-9C1C-4BAE-BBF6-44F5804B97A2 wds:Q58707750-976C8C73-E806-4A80-A8F5-B89832C4BB94 wds:Q58707750-ABF3D063-48B8-44F1-B41B-D5FF45722F7C wds:Q58707750-C9BAC633-3C40-4CB7-BC09-969B8DE1AA08 wds:Q58707750-F15C1785-D889-4189-AA92-5D176FC4B4F4 wds:Q58707750-FF56DB4C-8F1D-441E-B4E4-DBB5F6FC8898
author name string	Katja Conrath Tzyh-Chang Hwang Martin Andrews Andrew M Swensen Pieter Stouten Luc Nelles Ann Vandevelde Oscar Mammoliti Mia Jans Maarten Gees Anne-Sophie Wesse Jan Van der Schueren Katleen Verdonck Sara Musch Steven Van der Plas Kathleen Sonck
rdfs:label	Identification and Characterization of Novel CFTR Potentiators (en) Identification and Characterization of Novel CFTR Potentiators (nl)
skos:prefLabel	Identification and Characterization of Novel CFTR Potentiators (en) Identification and Characterization of Novel CFTR Potentiators (nl)
name	Identification and Characterization of Novel CFTR Potentiators (en) Identification and Characterization of Novel CFTR Potentiators (nl)
title	wds:Q58707750-2120A6B5-B247-44BD-8E34-5E0EE4EE8B2F
title	Identification and Characterization of Novel CFTR Potentiators (en)
page(s)	wds:Q58707750-32D78154-B98F-4DF0-9559-C96B71AAF0D4
page(s)	1221

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