About: Improving Potency, Selectivity, and Water Solubility of Adenosine A1 Receptor Antagonists: Xanthines Modified at Position 3 and Related Pyrimido[1,2,3-cd]purinediones

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About: Improving Potency, Selectivity, and Water Solubility of Adenosine A1 Receptor Antagonists: Xanthines Modified at Position 3 and Related Pyrimido[1,2,3-cd]purinediones Goto Sponge NotDistinct Permalink

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scientific article published on 01 August 2006

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в серпні 2006 (uk) im August 2006 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu n'agostu de 2006 (ast) scientific article published on 01 August 2006 (en)
publication date	wds:Q57708485-5C4666D5-1B75-4396-B2A3-5BDA5E1FD97E
publication date	2006-08-01 00:00:00Z (xsd:dateTime)
cites work	wds:Q57708485-17AE1F43-C828-4399-9322-990B629B847B wds:Q57708485-1F319942-9C4F-4EAE-B3F5-69BA1FE02A45 wds:Q57708485-2CC6F951-5333-4CBF-95B1-A1EB0672E62A wds:Q57708485-2D249AF6-80D7-48C4-B75B-AE22A3C56B75 wds:Q57708485-302F5CFF-1452-496C-9749-07309FE24EEF wds:Q57708485-30870B59-56A0-434B-809F-B2BE6EDF0E53 wds:Q57708485-30EC40D9-5538-4CAB-B42F-8CA35E0CBFB8 wds:Q57708485-4B9CD7D9-D78D-4C23-BFDD-5D9EFA66110A wds:Q57708485-5409E9AE-1B36-4FBB-9F03-AACD3AE8273F wds:Q57708485-5A7AE8C4-24D2-4E09-ADFE-F5E432D3162B wds:Q57708485-5DD916D3-21C2-43E1-8E40-9992BC6A45D0 wds:Q57708485-6478DE33-207C-4C52-885B-04B783243743 wds:Q57708485-6493C503-8EF3-4752-AF82-447BF5EC0A1C wds:Q57708485-6620BDB1-53C1-45B5-989A-6787239BB3A9 wds:Q57708485-668B32EF-39C5-40AB-B954-5B657B4A0BCB wds:Q57708485-68843180-20D9-4CA9-826D-075FD3D08BF6 wds:Q57708485-68C7E1CE-6AE1-46C7-BADC-392CB66E00CD wds:Q57708485-68D568C3-F93A-46B8-A1DD-2F3623257821 wds:Q57708485-6B9D8176-D544-4F6F-BEEC-78794878BC3A wds:Q57708485-8E01F4E1-604C-4254-89BE-E86A44CC1322 wds:Q57708485-8E0F3217-FA4B-4863-A2F9-9366EBC421DB wds:Q57708485-948370E4-5831-472C-81D3-B3B03E2DEF4A wds:Q57708485-AA0E7E9E-CE46-4B80-9D43-DDA2AC6BEB4A wds:Q57708485-BA7F6CF1-626D-4CD0-BA46-16297E503C12 wds:Q57708485-C2DD965A-FD8D-42ED-8E7C-2EABD332A067 wds:Q57708485-CE2DEA0E-94DD-4550-9CDB-64D14416C400 wds:Q57708485-E4C66966-01BE-4547-AA10-784449A96ECD wds:Q57708485-EEACAC33-DB2F-4C1A-8824-27EFE5B6A00B wds:Q57708485-F30858FE-7E77-4F19-81E5-06A9A2DCCDD7 wds:Q57708485-F679903B-D6B9-4470-A8F2-8C344A9B283F wds:Q57708485-FEAC4EF4-1428-45F7-8B09-267F711F0C46
cites work	2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors Adenosine A1 receptor antagonists and the kidney Antinociceptive effects of novel A2B adenosine receptor antagonists. 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists Medicinal chemistry of adenosine A3 receptor ligands [(3)H]8-Ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one ([(3)H]PSB-11), a novel high-affinity antagonist radioligand for human A(3) adenosine receptors Adenosine receptor agonists: from basic medicinal chemistry to clinical development Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists Effects of an adenosine A2A receptor blockade in the nucleus accumbens on locomotion, feeding, and prepulse inhibition in rats Catalepsy induced by a blockade of dopamine D1 or D2 receptors was reversed by a concomitant blockade of adenosine A(2A) receptors in the caudate-putamen of rats Motor effects induced by a blockade of adenosine A2A receptors in the caudate-putamen. Synthesis and pharmacology of pyrido[2,3-d]pyrimidinediones bearing polar substituents as adenosine receptor antagonists Adenosine receptors and their modulators Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine Binding of [3H]MSX-2 (3-(3-hydroxypropyl)-7-methyl-8-(m-methoxystyryl)-1-propargylxanthine) to rat striatal membranes--a new, selective antagonist radioligand for A(2A) adenosine receptors Multigram-scale syntheses, stability, and photoreactions of A2A adenosine receptor antagonists with 8-styrylxanthine structure: potential drugs for Parkinson's disease A detailed behavioral analysis of the acute motor effects of caffeine in the rat: involvement of adenosine A1 and A2A receptors Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists. Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential Der synthetische Aufbau der Harnsäure, des Xanthins, Theobromins, Theophyllins und Caffeïns aus der Cyanessigsäure Medicinal chemistry of adenosine A1 receptor ligands Electrophysiological and behavioural evidence for an antagonistic modulatory role of adenosine A2Areceptors in dopamine D2receptor regulation in the rat dopamine-denervated striatum A2B adenosine receptor antagonists: recent developments 2-Chloro-N6-[3H]cyclopentyladenosine ([3H]CCPA)--a high affinity agonist radioligand for A1 adenosine receptors Adenosine receptor ligands-recent developments part I. Agonists Synthesis and biological evaluation of CX-659S and its related compounds for their inhibitory effects on the delayed-type hypersensitivity reaction Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors. Versatile, convenient synthesis of pyrimido[1,2,3-cd]purinediones A2A adenosine receptor antagonists - future drugs for Parkinson's disease?
author name string	wds:Q57708485-1E19D0D1-5851-46C1-AD99-3CD7D70BC925 wds:Q57708485-3F4AC34C-5293-40ED-860A-2B9F9BBDD794 wds:Q57708485-86CD0F33-D3F0-4148-BBFE-AE69DD8042DA wds:Q57708485-CFA66AF8-E836-4C6F-88CB-9A9DBABC0F04 wds:Q57708485-D9AEFD96-0631-4FFF-AD3A-A993EBAB0E50
author name string	Stefanie Weyler Sonja Hinz Britta Schumacher Friederike Fülle Martina Diekmann
rdfs:label	Improving Potency, Selectivity, and Water Solubility of Adenosine A1 Receptor Antagonists: Xanthines Modified at Position 3 and Related Pyrimido[1,2,3-cd]purinediones (en) Improving Potency, Selectivity, and Water Solubility of Adenosine A1 Receptor Antagonists: Xanthines Modified at Position 3 and Related Pyrimido[1,2,3-cd]purinediones (nl)
skos:prefLabel	Improving Potency, Selectivity, and Water Solubility of Adenosine A1 Receptor Antagonists: Xanthines Modified at Position 3 and Related Pyrimido[1,2,3-cd]purinediones (en) Improving Potency, Selectivity, and Water Solubility of Adenosine A1 Receptor Antagonists: Xanthines Modified at Position 3 and Related Pyrimido[1,2,3-cd]purinediones (nl)
name	Improving Potency, Selectivity, and Water Solubility of Adenosine A1 Receptor Antagonists: Xanthines Modified at Position 3 and Related Pyrimido[1,2,3-cd]purinediones (en) Improving Potency, Selectivity, and Water Solubility of Adenosine A1 Receptor Antagonists: Xanthines Modified at Position 3 and Related Pyrimido[1,2,3-cd]purinediones (nl)
author	wds:Q57708485-2864C5BE-7F1B-4A9B-9E6D-28E976E37B79 wds:Q57708485-B6CB9079-75EF-4DF1-8233-B4A8D49F3027
author	Christa E Müller Karl-Norbert Klotz
title	wds:Q57708485-0B1FDD46-57E0-4DDE-8040-777F0ECC9945
title	Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones (en)
page(s)	wds:Q57708485-56BDAFBB-76B3-4DE5-8362-10F00977E165
page(s)	891-902
instance of	wds:Q57708485-5B3F90D3-B5A7-419F-9C21-23AD9BFC4717
instance of	scholarly article
main subject	wds:Q57708485-62E03DE6-BE30-412A-B1B4-B0BA84F7A6A6
main subject	molecular medicine
PubMed ID	wds:Q57708485-0C8E6412-31B7-4896-A1A5-1494C0EEB757
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16902942

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