About: Jak2 Acts as Both a STAT1 Kinase and as a Molecular Bridge Linking STAT1 to the Angiotensin II AT1Receptor

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About: Jak2 Acts as Both a STAT1 Kinase and as a Molecular Bridge Linking STAT1 to the Angiotensin II AT1Receptor Goto Sponge NotDistinct Permalink

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scientific article published in Journal of Biological Chemistry

Attributes	Values
rdf:type	Item
description	artículu científicu (ast) wetenschappelijk artikel (nl) наукова стаття, опублікована в березні 2000 (uk) article publié dans la revue scientifique Journal of Biological Chemistry (fr) im Mai 2000 veröffentlichter wissenschaftlicher Artikel (de) scientific article published in Journal of Biological Chemistry (en)
publication date	wds:Q57630557-7664D74A-CB10-4B35-B839-F7D66DD0709E
publication date	2000-05-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q57630557-69CC33C8-A456-4245-9C2A-79AAEEC5AE47
language of work or name	English
cites work	wds:Q57630557-0AB8E104-CF2A-41A6-8520-7060C56077A8 wds:Q57630557-0F6E72F7-A60B-4453-98A0-FDD4526280FE wds:Q57630557-1FC6BEC2-C025-4692-86C4-AC6663A333DA wds:Q57630557-2066755E-6E6B-4B62-98E1-AA173B832E17 wds:Q57630557-76E97E8C-3B43-4779-8E55-5777AA0A1985 wds:Q57630557-79080D35-FBC9-4E41-98DF-A09879269EA3 wds:Q57630557-855F997E-B236-4156-AD02-8B7157B27266 wds:Q57630557-8A7970A7-D68E-468C-AA58-A99AE24A4746 wds:Q57630557-98CE8D64-BCC5-4A98-8FF5-A6FFD5671E11 wds:Q57630557-AC0BDF16-F929-4875-8D8A-43F8956F3C45 wds:Q57630557-B15F6F1C-1140-40DC-849A-EB18F5AF0336 wds:Q57630557-B8DC5FF4-C195-4D92-99D9-2191ABED0580 wds:Q57630557-BA2D383E-50B2-46BF-8204-2DBBBE9EACDD wds:Q57630557-BD4B8E87-0F7B-4D91-A08A-795B77D22AED wds:Q57630557-D2EA4F12-50B2-4F08-A9E1-EEA86D124E87 wds:Q57630557-DADE30C8-3E0D-452D-BA88-520E1F5CED99 wds:Q57630557-DC93C71E-96B5-4F99-9156-BFD73640A5C0 wds:Q57630557-EE4CE69A-977D-4A6A-9017-4A88B8A506D5 wds:Q57630557-F715C562-E171-400D-9604-A683DABA735B wds:Q57630557-F8DBF864-45B8-416D-BA83-6C96452AF8E8
cites work	Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C Intracellular tyrosine residues of the human growth hormone receptor are not required for the signaling of proliferation or Jak-STAT activation Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor Jaks and STATs: biological implications STATs: signal transducers and activators of transcription STAT activation by epidermal growth factor (EGF) and amphiregulin. Requirement for the EGF receptor kinase but not for tyrosine phosphorylation sites or JAK1. Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor Signaling by the cytokine receptor superfamily: JAKs and STATs. The type I angiotensin II receptor couples to Stat1 and Stat3 activation through Jak2 kinase in neonatal rat cardiac myocytes Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT. Activation of the STAT pathway by angiotensin II in T3CHO/AT1A cells. Cross-talk between angiotensin II and interleukin-6 nuclear signaling Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II. Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515 and TYR580. Nonpeptide angiotensin II receptor antagonists The Angiotensin II AT1 Receptor Is Tyrosine and Serine Phosphorylated and can Serve as a Substrate for the SRC Family of Tyrosine Kinases Angiotensin II signal transduction pathways
author name string	wds:Q57630557-E4CE6AC1-71A3-4251-99E9-17E804011F8A wds:Q57630557-FA0F61FD-DF6C-4D9E-9630-4F1EF49D9B17
author name string	Ali MS Sayeski PP
rdfs:label	Jak2 Acts as Both a STAT1 Kinase and as a Molecular Bridge Linking STAT1 to the Angiotensin II AT1Receptor (en) Jak2 Acts as Both a STAT1 Kinase and as a Molecular Bridge Linking STAT1 to the Angiotensin II AT1Receptor (nl)
skos:prefLabel	Jak2 Acts as Both a STAT1 Kinase and as a Molecular Bridge Linking STAT1 to the Angiotensin II AT1Receptor (en) Jak2 Acts as Both a STAT1 Kinase and as a Molecular Bridge Linking STAT1 to the Angiotensin II AT1Receptor (nl)
name	Jak2 Acts as Both a STAT1 Kinase and as a Molecular Bridge Linking STAT1 to the Angiotensin II AT1Receptor (en) Jak2 Acts as Both a STAT1 Kinase and as a Molecular Bridge Linking STAT1 to the Angiotensin II AT1Receptor (nl)
author	wds:Q57630557-A49F4D58-B855-465F-9AAE-706E085AC9C5
author	Kenneth Bernstein
title	wds:Q57630557-719E5CE7-3846-4930-85A9-F49EEB20289E
title	Jak2 acts as both a STAT1 kinase and as a molecular bridge linking STAT1 to the angiotensin II AT1 receptor (en)
page(s)	wds:Q57630557-9B7B1856-674C-4E12-BC19-3C63B6B39D32
page(s)	15586-15593
instance of	wds:Q57630557-F26DFE3F-7BE8-476B-B319-AA733A9F86FA
instance of	scholarly article
PubMed ID	wds:Q57630557-2972C98C-2C4D-4AD5-BBC1-82A9D7DFCB51
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10748109
PubMed ID	10748109
published in	wds:Q57630557-88EA289A-3F6E-4EBA-AF91-487105185007
published in	Journal of Biological Chemistry
issue	wds:Q57630557-7B82811A-7D8A-4F83-8DED-1A40109D4FE5
volume	wds:Q57630557-58665312-EC38-476C-9FA5-0F42737EC404
issue	20
volume	275
DOI	wds:Q57630557-7401606F-A47D-410F-A4F7-445AFE3ACD33
DOI	http://dx.doi.org/10.1074/JBC.M908931199
DOI	10.1074/JBC.M908931199
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q57630557
is cites work of	The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes Combining multiple structure and sequence alignments to improve sequence detection and alignment: application to the SH2 domains of Janus kinases Signaling at zero G: G-protein-independent functions for 7-TM receptors ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner Chemokine receptor dimerization: two are better than one. Angiotensin II mediated signal transduction. Important role of tyrosine kinases. The angiotensin II-dependent nuclear translocation of Stat1 is mediated by the Jak2 protein motif 231YRFRR. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Janus Kinase 2 Activation by the Platelet-Activating Factor Receptor (PAFR): Roles of Tyk2 and PAFR C Terminus Jak2 Tyrosine Kinase Mediates Angiotensin II-dependent Inactivation of ERK2 via Induction of Mitogen-activated Protein Kinase Phosphatase 1 Signal transduction mechanisms of the angiotensin II type AT(1)-receptor: looking beyond the heterotrimeric G protein paradigm STAT5A interacts with and is phosphorylated upon activation of the mu-opioid receptor Regulation of G protein-coupled receptor signaling by scaffold proteins Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells Minireview: Role of intracellular scaffolding proteins in the regulation of endocrine G protein-coupled receptor signaling Identification of tyrosine 972 as a novel site of Jak2 tyrosine kinase phosphorylation and its role in Jak2 activation Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors Mutation of glutamic acid residue 1046 abolishes Jak2 tyrosine kinase activity

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