About: Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma

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About: Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma Goto Sponge NotDistinct Permalink

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scientific article published on 01 May 2002

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в березні 2002 (uk) article scientifique publié en 2002 (fr) im März 2002 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en mayu de 2002 (ast) scientific article published on 01 May 2002 (en)
publication date	wds:Q57591227-9666C104-D9E0-4605-BD9D-86DF129CD4A6
publication date	2002-05-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q57591227-980E24CD-D419-44AC-9ACB-FA238EA109D4
language of work or name	English
cites work	wds:Q57591227-010EA223-C19F-4A6A-8CF6-1218F2256E3D wds:Q57591227-0890F26D-6BF2-4F4E-A63A-2DA9D27FFAA4 wds:Q57591227-16E2E81B-75F5-439F-BC2C-4848D18A9FBA wds:Q57591227-16F178DB-7007-4788-85E8-A3FFAFE1D0E2 wds:Q57591227-1D12A083-A153-4128-AE9E-595DB7E5FC62 wds:Q57591227-1F765C8A-F1B2-4C89-ACEC-4B89A2554988 wds:Q57591227-1F8FD6FD-20A0-41E5-B133-E5B0FEEFC704 wds:Q57591227-1FAE929C-AA0C-4F7A-9152-C01A29EAC0AF wds:Q57591227-205A7C4F-4EA7-4ED9-A16D-417E98A6A0AB wds:Q57591227-208D48B8-79FD-4D62-A999-BF7896C820FC wds:Q57591227-252DB4E6-A478-4640-B445-910924FAE4B6 wds:Q57591227-4E828E2B-9C5E-4EA0-90AF-E7B40ECAD5AD wds:Q57591227-572404BF-827D-4771-965A-8ADD20059EF0 wds:Q57591227-5F6759FC-8F9E-4799-8436-81AE8B02C493 wds:Q57591227-60471B69-1E66-44B6-BFBD-24B44621DC3A wds:Q57591227-62E238A4-C280-4C70-8ECA-97ACD31AD7F3 wds:Q57591227-6C2A6C42-27F8-4950-9898-2ACC4227C08D wds:Q57591227-6D6E9E9A-C1EE-4987-A467-210A11DE706B wds:Q57591227-7AE4658D-E868-47DA-95BC-1E0680FCA59F wds:Q57591227-7BBCF3B4-0CF1-4ADE-AAE8-48738C7B720E wds:Q57591227-8100DB4A-4EB1-47BC-8CA6-D860075E4E0E wds:Q57591227-8522AD4A-B9B8-4807-B362-2C8C0AB9C0FA wds:Q57591227-90A17875-E9F3-44DD-89D3-B36FDEABCFB7 wds:Q57591227-980BBF3D-59E4-4890-B233-2E98FD5ADDEB wds:Q57591227-AA6AE76E-85E6-4BE9-B1E5-C0B6D38833DB wds:Q57591227-D0F73DA2-067B-46D1-BBBB-9496CCDCEC20 wds:Q57591227-E2B4DFF6-845D-491D-9B5B-15621431CC9E wds:Q57591227-E82ED347-F796-4A9E-B3D8-C3E10A13DE2F wds:Q57591227-EB432217-C11A-444E-AAF2-8BE7AEFED9A1
cites work	Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas Growth factor and cytogenetic abnormalities in cultured nevi and malignant melanomas The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model Regulation of PTEN transcription by p53 Variation in cancer risks, by mutation position, in BRCA2 mutation carriers Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome Localization of the gene for Cowden disease to chromosome 10q22–23 PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways Epigenetic PTEN silencing in malignant melanomas without PTEN mutation 10q deletions in metastatic cutaneous melanoma Identification of PTEN mutations in metastatic melanoma specimens Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast p53 expression and risk factors for cutaneous melanoma: a case-control study. Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis Allelic loss of 10q23, the PTEN tumour suppressor gene locus, in Barrett's oesophagus-associated adenocarcinoma
author name string	wds:Q57591227-5E71099E-7670-4A22-82F7-78C42E3F1B71 wds:Q57591227-97BC8EB1-BACC-4030-B3D3-F5CB07430285 wds:Q57591227-989DD2D9-904A-4F6C-92C2-791129245AA2 wds:Q57591227-FED5213E-3998-4D92-8A32-05ED6E5D86CC
author name string	Nicholas K Hayward Margaret C Cummings Sandra Pavey Xiao-Ping Zhou
rdfs:label	Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma (en) Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma (nl)
skos:prefLabel	Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma (en) Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma (nl)
name	Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma (en) Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma (nl)
author	wds:Q57591227-57EF4BED-EB05-4E46-B8A0-57D6FFB5907A wds:Q57591227-F90DFDF6-FD4C-4FCE-8DA7-5DEFA42CB59F
author	Charis Eng David C. Whiteman
title	wds:Q57591227-49B3AFDB-CEC5-413B-A8B5-1054332D871E
title	Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma (en)
page(s)	wds:Q57591227-2C6FCE35-2070-4AEA-BB8B-9A12F9CEB480
page(s)	63-67
instance of	wds:Q57591227-4183DE51-98D6-4D4C-8DCB-0B7BA693F260
instance of	scholarly article
main subject	wds:Q57591227-D3AEA661-D63B-418F-ABAA-CA863E457E7E
main subject	cancer research
PubMed ID	wds:Q57591227-9550102E-5363-4AC9-BDBC-0734838A4AE1
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11948493
PubMed ID	11948493
published in	wds:Q57591227-841C49AC-1700-4EE3-A8DF-A3DD35A46BCB
published in	International Journal of Cancer

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