About: Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 V

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About: Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 V Goto Sponge NotDistinct Permalink

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description	article (en) հոդված (hy) wetenschappelijk artikel (nl) наукова стаття, опублікована в травні 2004 (uk) im Mai 2004 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q57480046-3E6F0FAA-2446-466E-BB30-C1EDEBE0AEE2
publication date	2004-05-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q57480046-0744D4EC-BEC9-4B5E-8401-163CDAE56B13
language of work or name	English
author name string	wds:Q57480046-048771B7-5ED4-446D-9E72-01693C2019E3 wds:Q57480046-12847D3E-8EE3-4544-8B93-54A4722FC6A3 wds:Q57480046-14DD50C6-E82F-4E68-8D2D-54C2784DF51F wds:Q57480046-201BB33F-B671-48A7-862E-DA544C447372 wds:Q57480046-289ECB84-6279-4F13-A80F-9A1E59C8DCC2 wds:Q57480046-3D249E5C-33C7-477D-837E-3A0A001E8A09 wds:Q57480046-44602896-FBAB-4E49-B9E9-64790EDA416E wds:Q57480046-4618F4D3-71B7-4569-814F-235FDD8468BA wds:Q57480046-6014F99C-3A1E-449C-A009-0C9FE2BF5031 wds:Q57480046-70BD9A1F-21B9-42B9-97CB-0DE8F1837FB6 wds:Q57480046-798AC18F-8442-495D-8805-4F3276CFC80C wds:Q57480046-847AA5F4-5A57-474E-93E7-EB7FAB2BEC12 wds:Q57480046-8898B245-BFB2-4A50-A274-74B45EFA0662 wds:Q57480046-90E1FFBD-292A-45E0-8FD6-5099E7DF2A64 wds:Q57480046-98EE5540-B979-4CE7-890B-B6AAE9FF6D1C wds:Q57480046-A09F67F8-B4FE-486C-8082-8C9381DE8DE7 wds:Q57480046-A64F0BE6-1E6F-4700-AC8F-3909AF6EBFB3 wds:Q57480046-B7A9ABDE-99DE-4525-B0E3-773284FC45D5 wds:Q57480046-CA38475F-BE8A-48D2-B1F2-5A0A3E9E16C6 wds:Q57480046-D84ECD6C-4C80-4FA2-9094-5BDA8923551D wds:Q57480046-DE178829-C35A-4153-B782-5F4535E87A36
author name string	Rudi Pauwels Hong Ye Eddy Arnold Koen Andries Marie-Pierre de Béthune Jan Heeres Paul L. Boyer Paul J. Lewi Paul A. J. Janssen Patrick Clark Bart De Corte Michael J. Kukla Arthur D. Clark, Chih Y. Ho Donald W. Ludovici Frederik Daeyaert H. Maarten Vinkers Lucien M. H. Koymans Marc R. de Jonge Mark. A. Lichtenstein Robert W. Kavash
rdfs:label	Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 V (en) Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (nl)
skos:prefLabel	Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 V (en) Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (nl)
name	Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 V (en) Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (nl)
author	wds:Q57480046-5A9692BD-8988-4DE5-8C2E-D01868AFD656 wds:Q57480046-5B26E0E7-BD79-491C-9129-3824D78FCCE9
author	Stephen H. Hughes Kalyan Das
title	wds:Q57480046-752F4A03-1962-424D-8244-AF8B55A167F1
title	Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 V (en)
page(s)	wds:Q57480046-0EA24AB3-7422-4C26-845C-6A21CE81D95C
page(s)	2550-2560
instance of	wds:Q57480046-C6674B75-2EF1-476D-A9D8-C05FB3AD9129
instance of	scholarly article
PubMed ID	wds:Q57480046-5921D7BC-3AD1-48DA-A415-1E9C44FD9050
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15115397
PubMed ID	15115397
published in	wds:Q57480046-54A40E8C-8FA3-4A73-A43A-02A4DEBC54D6
published in	Journal of Medicinal Chemistry
issue	wds:Q57480046-61E3F46E-1D33-47DB-A1AB-5A24C46ECA18
volume	wds:Q57480046-DB890605-AB5E-41AF-B9E8-DEA35D76A39A
issue	10
volume	47
DOI	wds:Q57480046-C5CCF963-59BD-4EA9-901C-1D4C737CDFD7
DOI	http://dx.doi.org/10.1021/JM030558S
DOI	10.1021/JM030558S
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q57480046
is cites work of	Winning the arms race by improving drug discovery against mutating targets Compartmental transport model of microbicide delivery by an intravaginal ring Application of normal-mode refinement to X-ray crystal structures at the lower resolution limit Crystal Structures of HIV-1 Reverse Transcriptase with Picomolar Inhibitors Reveal Key Interactions for Drug Design Extension into the entrance channel of HIV-1 reverse transcriptase—Crystallography and enhanced solubility A mechanistic and structural investigation of modified derivatives of the diaryltriazine class of NNRTIs targeting HIV-1 reverse transcriptase Discovery of dimeric inhibitors by extension into the entrance channel of HIV-1 reverse transcriptase Biochemical mechanism of HIV-1 resistance to rilpivirine Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy Elucidating the inhibition mechanism of HIV-1 non-nucleoside reverse transcriptase inhibitors through multicopy molecular dynamics simulations Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase Etravirine for the treatment of HIV infection. Comparison of the Mechanisms of Drug Resistance among HIV, Hepatitis B, and Hepatitis C. Improving Viral Protease Inhibitors to Counter Drug Resistance Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase Polarization Effects for Hydrogen-Bonded Complexes of Substituted Phenols with Water and Chloride Ion Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore

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