About: Targeting gene expression to hypoxic tumor cells

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description	article (en) wetenschappelijk artikel (nl) наукова стаття, опублікована в травні 1997 (uk) article scientifique publié en 1997 (fr) im Mai 1997 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q57377984-9585DBE0-1348-4E13-A486-4619F38F9680
publication date	1997-05-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q57377984-66A5B8ED-5223-4463-840E-69B7F947A2CF
language of work or name	English
exact match	wds:Q57377984-D742221B-FFDF-481D-A6B5-DBF4BED8D95B
exact match	https://scigraph.springernature.com/pub.10.1038/nm0597-515
cites work	wds:Q57377984-2111E586-FF3C-4EFD-98DF-044A239F6F57 wds:Q57377984-29A55477-62E9-4671-BFE2-4200C98B5047 wds:Q57377984-2A3981F7-61C2-4534-AA69-9A7266DB72C7 wds:Q57377984-2DC55BE2-7D73-42F1-BC78-46BD59E4FD8D wds:Q57377984-3BD1D847-E2AA-4FBD-B2A6-9FB7839F4845 wds:Q57377984-3F15EA19-4C12-46B3-AE24-7CFB6E2BEEA8 wds:Q57377984-55D02FE4-9A30-43E2-BFA3-D69DA79E6288 wds:Q57377984-6D4AB6A2-AA47-44B9-9357-542B57CF5191 wds:Q57377984-716B3C82-0EC1-41CD-8E14-B7A5427CB2B3 wds:Q57377984-7C0EA8AE-9189-4CC5-A0B1-471335773638 wds:Q57377984-8614055D-8DAE-4F10-8DFD-ABFCD6381ABB wds:Q57377984-882B34B6-53DD-432C-AAFD-968B47D1FDE2 wds:Q57377984-94F7F493-63A5-478C-B6B8-DAF508D7FA15 wds:Q57377984-9B7225C3-90ED-48DF-ADB4-634F57E0C6BC wds:Q57377984-A43A5899-218C-4C6C-83A2-E7E57BE3E7D5 wds:Q57377984-A6C78ED4-BAC8-4A42-8C22-5A4F060A0A7A wds:Q57377984-C0AEB6C0-5900-4871-B41D-62BE4D1AE221 wds:Q57377984-CD9E1B1E-7FBF-4D1E-A88C-8DAE42ADC082 wds:Q57377984-DD1F9B6D-C9E4-46FF-BD71-E648921D400E wds:Q57377984-F5CE03CB-BD55-4B6A-B9DC-9BB7E6DFE4B7 wds:Q57377984-F70267DB-8E64-4C4A-8412-86B2AC72F0A0
cites work	The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism What Is the Evidence That Tumors Are Angiogenesis Dependent? Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis Oxygen sensing and molecular adaptation to hypoxia Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. II. RSU 1069 Spatial and temporal control of gene therapy using ionizing radiation Tissue-specific targeting of retroviral vectors through ligand-receptor interactions The experimental development of bioreductive drugs and their role in cancer therapy. Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system Radiation sensitization and chemopotentiation: RSU 1069, a compound more efficient than misonidazole in vitro and in vivo Pyrimidine, purine and nitrogen control of cytosine deaminase synthesis in Escherichia coli K 12. Involvement of the glnLG and purR genes in the regulation of codA expression Characterisation of functional domains within the mouse erythropoietin 3' enhancer conveying oxygen-regulated responses in different cell lines
author name string	wds:Q57377984-77D23D62-50CC-499D-9B1D-526B02169023 wds:Q57377984-84BA9C7B-63A5-4D6F-83D6-DD0C5D750F6D wds:Q57377984-D2DE738E-A70D-4E43-8BC2-F42CF980B472 wds:Q57377984-DD46AD9A-5DA1-402C-92F1-FFAA558008C5
author name string	A L Harris K M Townsend G U Dachs J D Firth
rdfs:label	Targeting gene expression to hypoxic tumor cells (en) Targeting gene expression to hypoxic tumor cells (nl)
skos:prefLabel	Targeting gene expression to hypoxic tumor cells (en) Targeting gene expression to hypoxic tumor cells (nl)
name	Targeting gene expression to hypoxic tumor cells (en) Targeting gene expression to hypoxic tumor cells (nl)
author	wds:Q57377984-07A3CEEC-CADF-4CE8-8318-C288A8371BFD wds:Q57377984-30B8EBA3-EDC7-4716-AAD0-08590464FEF2 wds:Q57377984-8826D574-CD0F-4841-A304-01773D9F9950
author	Peter J. Ratcliffe Ian J Stratford Adam Patterson
title	wds:Q57377984-CB9D20E1-7E77-456F-8184-ED0D76FDDE14
title	Targeting gene expression to hypoxic tumor cells (en)
page(s)	wds:Q57377984-979A2815-B711-4AD2-BC2A-8BB2CD32FF29
page(s)	515-520
instance of	wds:Q57377984-2F909089-DB1C-4E7D-9C2D-F3CBED992D5F
instance of	scholarly article
main subject	wds:Q57377984-C8B120E0-E185-44B2-A6B1-7ABAC112ED03
main subject	hypoxia
PubMed ID	wds:Q57377984-58FAEB77-407C-4CB6-A0C3-D575561B1805
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9142119
PubMed ID	9142119
published in	wds:Q57377984-A21D5332-80B9-4739-BCAB-C12B8D5DBDC4
published in	Nature Medicine
issue	wds:Q57377984-E0F04704-BCBC-42A3-B458-87AC0D79D6D4
volume	wds:Q57377984-75BC7224-F742-4042-8AB2-A3F093AB92D7
issue	5
volume	3
DOI	wds:Q57377984-65703D0E-FA6F-4574-930C-E6FC5552FE62
DOI	http://dx.doi.org/10.1038/NM0597-515
DOI	10.1038/NM0597-515
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q57377984
is cites work of	Tumor-associated macrophages: a molecular perspective Regulation of a rat VL30 element in human breast cancer cells in hypoxia and anoxia: role of HIF-1 Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation Transcriptionally targeted gene therapy to detect and treat cancer Mutation in pre-mRNA adenosine deaminase markedly attenuates neuronal tolerance to O2 deprivation in Drosophila melanogaster

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