About: Improved detection of melanoma antigen-specific T cells expressing low or high levels of CD8 by HLA-A2 tetramers presenting a Melan-A/Mart-1 peptide analogue

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About: Improved detection of melanoma antigen-specific T cells expressing low or high levels of CD8 by HLA-A2 tetramers presenting a Melan-A/Mart-1 peptide analogue Goto Sponge NotDistinct Permalink

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article published in 2001

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в жовтні 2001 (uk) im Oktober 2001 veröffentlichter wissenschaftlicher Artikel (de) article published in 2001 (en)
publication date	wds:Q57209299-8CC36569-9412-414D-AE5F-8872B226C558
publication date	2001-10-06 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q57209299-65B65C7A-6761-4A67-BC5C-A9CCCB8B0CBC
language of work or name	English
cites work	wds:Q57209299-014B34A7-B182-419E-A987-2E07F7CA646C wds:Q57209299-090FB51C-5CF5-4E86-B0CC-406C245049CF wds:Q57209299-0C928F74-1B74-4199-9CD7-80756DB2F55E wds:Q57209299-1619B89C-18C0-4F8B-9B3A-4160FE132753 wds:Q57209299-1854AC31-561D-4A27-81AF-2AEC391507E8 wds:Q57209299-1A0E5AB2-B43C-470C-A3B8-BF4EBA373AE9 wds:Q57209299-21BADAF9-0B9B-4B57-AEBB-476FEA7F8D3C wds:Q57209299-29E84127-DBAB-499B-B475-2911465BE27C wds:Q57209299-382519F8-6FD1-45FB-935D-155F672DEF16 wds:Q57209299-3CA26495-0E8C-4E33-8E37-64A581412322 wds:Q57209299-45B96549-2E56-40AF-B82A-5E0DD404F504 wds:Q57209299-48A5F499-D193-421B-9E40-3FB8BDFB0870 wds:Q57209299-5510600C-66A2-4B47-BC4C-AA9C828CB497 wds:Q57209299-66EAFB97-0739-4EE0-AF16-40CB83E5D785 wds:Q57209299-6C76D5A0-3180-411C-87DF-9AD08ADB1AD1 wds:Q57209299-6DEB468C-2AC8-4011-8BE2-9F1A2306FE88 wds:Q57209299-7FF260F9-D468-4468-B374-B9CFBD8EAF52 wds:Q57209299-80B1D895-0FB0-4565-A144-5626941B49C3 wds:Q57209299-8471E856-5704-4C98-8FC5-C8080F94649C wds:Q57209299-94905198-DA01-4213-AF01-677818FBF648 wds:Q57209299-A0B3417B-8882-4D7A-A839-D3DB2B22C316 wds:Q57209299-BB87AD6D-9418-4C42-A28F-0FAF887B2A17 wds:Q57209299-BD794080-34B4-44ED-B6CF-3F905610AF32 wds:Q57209299-C1B0653D-2B58-419A-A17F-E7EBBDF55F40 wds:Q57209299-C608B3A5-B628-45FF-BA9D-B61705A2A72D wds:Q57209299-DFAE9D85-64B4-4456-88C4-92A72FE3846D wds:Q57209299-E47EC16A-71C7-49BA-86B3-9B63D30C03E4 wds:Q57209299-F366EADC-770A-4650-8949-090538580E67 wds:Q57209299-F3BD422E-62A4-4D8D-9C2A-CA65C91EBADA
cites work	T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes Tetramer-guided analysis of TCR beta-chain usage reveals a large repertoire of melan-A-specific CD8+ T cells in melanoma patients Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy Identification of epitope mimics recognized by CTL reactive to the melanoma/melanocyte-derived peptide MART-1(27-35) Mass spectrometric identification of a naturally processed melanoma peptide recognized by CD8+ cytotoxic T lymphocytes T-cell repertoire diversity and clonal expansions in normal and clinical samples Phenotypic analysis of antigen-specific T lymphocytes CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T cell receptor/CD3/zeta complex. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients Specificity pockets for the side chains of peptide antigens in HLA-Aw68 A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2. Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8. CD8 independence and specificity of cytotoxic T lymphocytes restricted by HLA-Aw68. 1 Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus HLA-peptide tetrameric complexes CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes Efficient detection and immunomagnetic sorting of specific T cells using multimers of MHC class I and peptide with reduced CD8 binding Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific. Cytotoxic T lymphocytes define multiple peptide isoforms derived from the melanoma-associated antigen MART-1/Melan-A Optimal activation of tumor-reactive T cells by selected antigenic peptide analogues. TCR usage in CTLs recognizing melanoma/melanocyte antigens. Critical role for CD8 in binding of MHC tetramers to TCR: CD8 antibodies block specific binding of human tumor-specific MHC-peptide tetramers to TCR.
author name string	wds:Q57209299-24D65599-E9F2-4B97-8818-537662465C4C wds:Q57209299-25871054-A25B-48D8-A791-70950585C3DD wds:Q57209299-281480D4-08A3-4314-AD67-0EBBB70662A4 wds:Q57209299-2DB0D235-2EB2-4CE2-BF9C-5C7D889871CA wds:Q57209299-484DCA08-DEC2-478D-92B7-150DCFAFAFB9 wds:Q57209299-8835A287-F0A1-4976-8007-AB8088E23720 wds:Q57209299-D9C37ECD-F263-44EC-8029-8D6B6F5CC007
author name string	Kirsten Freitag Chiara Castelli Claudia Neukirch Hanni Höhn Antje Necker Markus J. Maeurer Russell D. Salter
rdfs:label	Improved detection of melanoma antigen-specific T cells expressing low or high levels of CD8 by HLA-A2 tetramers presenting a Melan-A/Mart-1 peptide analogue (en) Improved detection of melanoma antigen-specific T cells expressing low or high levels of CD8 by HLA-A2 tetramers presenting a Melan-A/Mart-1 peptide analogue (nl)
skos:prefLabel	Improved detection of melanoma antigen-specific T cells expressing low or high levels of CD8 by HLA-A2 tetramers presenting a Melan-A/Mart-1 peptide analogue (en) Improved detection of melanoma antigen-specific T cells expressing low or high levels of CD8 by HLA-A2 tetramers presenting a Melan-A/Mart-1 peptide analogue (nl)
name	Improved detection of melanoma antigen-specific T cells expressing low or high levels of CD8 by HLA-A2 tetramers presenting a Melan-A/Mart-1 peptide analogue (en) Improved detection of melanoma antigen-specific T cells expressing low or high levels of CD8 by HLA-A2 tetramers presenting a Melan-A/Mart-1 peptide analogue (nl)
author	wds:Q57209299-834B98E1-E7D5-427D-B76B-5D54008CC155 wds:Q57209299-E214AE86-4F72-4B67-B0D8-033E8AAB6119 wds:Q57209299-E53C4A0A-CB63-4678-920A-0DD46A824C2E
author	Alexander Knuth Julia Karbach Elke Jäger
title	wds:Q57209299-257F5CA9-B5DF-46F0-80F7-9375A28EAC91
title	Improved detection of melanoma antigen-specific T cells expressing low or high levels of CD8 by HLA-A2 tetramers presenting a Melan-A/Mart-1 peptide analogue (en)
page(s)	wds:Q57209299-FE2D5B3B-811A-4528-AAEC-E0D91732A0E6
page(s)	64-71
instance of	wds:Q57209299-386864BE-DF79-4F70-BF60-68293186CEAF
instance of	scholarly article
main subject	wds:Q57209299-BC2DAAC4-C1C0-462E-981E-60AFF84622F9

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