About: Tissue concentrations of clozapine and its metabolites in the rat

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About: Tissue concentrations of clozapine and its metabolites in the rat Goto Sponge NotDistinct Permalink

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scientific article published on 01 September 1993

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована у вересні 1993 (uk) article scientifique publié en 1993 (fr) im September 1993 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en setiembre de 1993 (ast) scientific article published on 01 September 1993 (en)
publication date	wds:Q57133642-765E9FFA-86DC-4F1C-9DF6-15BBD87E3717
publication date	1993-09-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q57133642-61EA0BE2-CD15-4082-A2DE-A169ECCAF48C
language of work or name	English
exact match	wds:Q57133642-153AA450-66FE-4A2D-88D5-3B8EF7A1B0C7
exact match	https://scigraph.springernature.com/pub.10.1038/npp.1993.50
author name string	wds:Q57133642-0F202878-D4E1-4484-954D-729E252B11EF wds:Q57133642-15F81BB3-2A16-46F9-A41E-4E884C4883A9 wds:Q57133642-24B20876-E3A3-4660-BBDA-6D6569354009 wds:Q57133642-7C426218-C144-401E-8CDB-11D5420C9B1E wds:Q57133642-A6801EEE-2604-44EB-855A-BACE4C8DF4A2 wds:Q57133642-DDF24A19-B1FA-4F21-8A7E-D008955CD45C
author name string	B M Cohen J G Flood R J Baldessarini F Centorrino D Huston-Lyons S A Volpicelli
rdfs:label	Tissue concentrations of clozapine and its metabolites in the rat (en) Tissue concentrations of clozapine and its metabolites in the rat (nl)
skos:prefLabel	Tissue concentrations of clozapine and its metabolites in the rat (en) Tissue concentrations of clozapine and its metabolites in the rat (nl)
name	Tissue concentrations of clozapine and its metabolites in the rat (en) Tissue concentrations of clozapine and its metabolites in the rat (nl)
title	wds:Q57133642-6A335911-2B89-4C99-B9A3-AF9C7B6BD3FE
title	Tissue concentrations of clozapine and its metabolites in the rat (en)
page(s)	wds:Q57133642-0E7E771E-CEF8-4D12-B4E1-3F8B3A37FD28
page(s)	117-124
instance of	wds:Q57133642-7BDB3332-5CCE-4C98-99A6-850939D8C8C8
instance of	scholarly article
PubMed ID	wds:Q57133642-C8DD39F8-2BA6-4F4D-97D1-212BA7598ACE
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8216694
PubMed ID	8216694
published in	wds:Q57133642-20F3930E-FDBD-43C2-8863-F2EE8D8AAD51
published in	Neuropsychopharmacology
issue	wds:Q57133642-24DE886F-72C9-49D1-A799-A957BE6145AF
volume	wds:Q57133642-15E0C94B-5CA0-40AD-99E0-46FE0B1C15BB
issue	2
volume	9
DOI	wds:Q57133642-19E9EAFB-B9F2-421B-9521-A4F98E107891
DOI	http://dx.doi.org/10.1038/NPP.1993.50
DOI	10.1038/NPP.1993.50
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q57133642
is cites work of	Effects of clozapine on the delta- and kappa-opioid receptors and the G-protein-activated K+ (GIRK) channel expressed in Xenopus oocytes Brain structures and neurotransmitters regulating aggression in cats: implications for human aggression Acute administration of typical and atypical antipsychotics reduces EEG γ power, but only the preclinical compound LY379268 reduces the ketamine-induced rise in γ power Risperidone plasma levels, clinical response and side-effects Clozapine interaction with phosphatidyl inositol 3-kinase (PI3K)/insulin-signaling pathway in Caenorhabditis elegans Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine Clozapine and prazosin slow the rhythm of head movements during focused stereotypy induced by d-amphetamine in rats Drug detection and quantification directly from tissue using novel ionization methods for mass spectrometry Chronical haloperidol and clozapine treatment in rats: differential RNA display analysis, behavioral studies and serum level determination. Clozapine chronically suppresses alcohol drinking in Syrian golden hamsters The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine Neuroleptics and animal models: feasibility of oral treatment monitored by plasma levels and receptor occupancy assays. Metabolism of clozapine by rat brain: the role of flavin-containing monooxygenase (FMO) and cytochrome P450 enzymes. N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors Evaluation of N-desmethylclozapine as a potential antipsychotic--preclinical studies N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- d -aspartate receptor activity Enhanced disease reduction using clozapine, an atypical antipsychotic agent, and glatiramer acetate combination therapy in experimental autoimmune encephalomyelitis Interaction of clozapine with the histamine H3 receptor in rat brain Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes A 200-kb region of human chromosome 22q11.2 confers antipsychotic-responsive behavioral abnormalities in mice Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-D-aspartic acid receptor up-regulation Psychoactive drugs affect glucose transport and the regulation of glucose metabolism Inhibition of glucose transport in PC12 cells by the atypical antipsychotic drugs risperidone and clozapine, and structural analogs of clozapine Clinical pharmacokinetics of fluoxetine Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice Clinically significant interactions of psychotropic agents with antipsychotic drugs Effect of chronic infusion of olanzapine and clozapine on food intake and body weight gain in male and female rats Effects of chronic clozapine administration on markers of arachidonic acid cascade and synaptic integrity in rat brain Atypical antipsychotic drugs directly impair insulin action in adipocytes: effects on glucose transport, lipogenesis, and antilipolysis Pharmacokinetic-pharmacodynamic modelling in the early development phase of anti-psychotics: a comparison of the effects of clozapine, S 16924 and S 18327 in the EEG model in rats Dopamine and serotonin metabolism in response to chronic administration of fluvoxamine and haloperidol combined treatment. Chemical-genetic attenuation of focal neocortical seizures The moderate affinity of clozapine at H3 receptors is not shared by its two major metabolites and by structurally related and unrelated atypical neuroleptics. The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine Second-generation antipsychotic drugs, olanzapine, quetiapine, and clozapine enhance neurite outgrowth in PC12 cells via PI3K/AKT, ERK, and pertussis toxin-sensitive pathways Chronic clozapine reduces rat brain arachidonic acid metabolism by reducing plasma arachidonic acid availability In rats chronically treated with clozapine, tyrosine depletion attenuates the clozapine-induced in vivo increase in prefrontal cortex dopamine and norepinephrine levels. Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and extracellular signal-regulated kinase activation Mechanistic connections between glucose/lipid disturbances and weight gain induced by antipsychotic drugs Distribution of clozapine and desmethylclozapine between blood and brain in rats. Reversible metabolism of clozapine and clozapine N-oxide in schizophrenic patients Comparison of the effects of antipsychotics on a delayed radial maze task in the rat. Comparative analysis of the treatment of chronic antipsychotic drugs on epileptic susceptibility in genetically epilepsy-prone rats Effects of clozapine, haloperidol and iloperidone on neurotransmission and synaptic plasticity in prefrontal cortex and their accumulation in brain tissue: an in vitro study Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action Clozapine inhibits synaptic transmission at GABAergic synapses established by ventral tegmental area neurones in culture A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target Clozapine N-Oxide Administration Produces Behavioral Effects in Long-Evans Rats: Implications for Designing DREADD Experiments.

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