About: Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte h

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About: Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte h Goto Sponge NotDistinct Permalink

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description	article (en) հոդված (hy) wetenschappelijk artikel (nl) наукова стаття, опублікована у 2007 (uk) article scientifique publié en 2007 (fr) im Jahr 2007 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q57086097-E6C1605D-3BA9-4B27-84BE-D7FF26929336
publication date	2007-01-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q57086097-F61DBCCD-0976-4A8F-A36C-66A09D859651
language of work or name	English
exact match	wds:Q57086097-E598DEDE-0E0F-4305-BCA6-C367F6FD5237
exact match	https://scigraph.springernature.com/pub.10.1186/ar2273
cites work	wds:Q57086097-009646C5-337F-4E7D-842F-7917F761A7B2 wds:Q57086097-052022AE-98AE-4BAB-99C7-7A12E4EA2200 wds:Q57086097-112E10C9-7F44-4F45-B42A-08EBC73480BA wds:Q57086097-122F051D-6911-4CE5-9F1C-EB1A3A6E9EAC wds:Q57086097-1AD9A127-5393-4F4E-9777-90F9A47F4820 wds:Q57086097-1DAA150D-0169-4E12-9C1B-43EEB048C3DA wds:Q57086097-1F96ADFB-7520-4FC4-A8A9-054D1CD46C94 wds:Q57086097-2174AF5A-62DF-46E3-8425-93459C96A620 wds:Q57086097-21A8CFD6-2672-4D5E-858F-8A20E12C2D34 wds:Q57086097-267B9E49-FA0C-4A5D-9248-33306DF9BE10 wds:Q57086097-26CF8FF8-F481-4608-9F4B-55B0E3C98102 wds:Q57086097-40B912B7-5E04-44E0-AA48-A6877A03E5B8 wds:Q57086097-473573EC-992E-4127-BBEE-DDBC705B164B wds:Q57086097-4BC5079E-9C12-4EA8-9F6B-44A8090DED5C wds:Q57086097-4D43F517-59D5-4733-81B1-B540D76E52A3 wds:Q57086097-5348628A-6D02-4412-AAA3-7CB96AF24BF2 wds:Q57086097-58EC75E6-1C02-4092-AF7E-D1BAE3711CB5 wds:Q57086097-65CA82EF-3068-4644-93A1-74D51D10B9F5 wds:Q57086097-6A03A09D-2CAF-4961-8E78-CBE11C7B66AE wds:Q57086097-6A79F25D-5AD8-49BB-9E6D-089F3EDFE41B wds:Q57086097-75B9DE26-94E2-44AE-80A7-8529C234A7EF wds:Q57086097-78C9FCF7-EF52-4814-9D2F-183D93AA2F0B wds:Q57086097-7B3C5536-82D3-4222-8000-780ED78A7399 wds:Q57086097-81C21904-EB5A-46F4-88A2-5DCEF15C2242 wds:Q57086097-842C71CB-595F-4732-8D19-8BA9EDF37020 wds:Q57086097-90923FF8-6E30-427A-BA52-A7BCC9F611B2 wds:Q57086097-950E5F88-24AB-4B79-86E6-B6529002C984 wds:Q57086097-A22026D3-2CEB-47C1-AD3F-2AE53E1DE9D2 wds:Q57086097-A73D4093-0A62-4052-99CC-C3E011884626 wds:Q57086097-AC8FE6A0-68E6-4554-BBDD-9B3BF7B1725F wds:Q57086097-B01FF0EF-3F9B-48DF-8DE6-F7E6BA3F6016 wds:Q57086097-B0F689EC-CB20-40A8-8BB8-50B3FA1B4523 wds:Q57086097-B4A22B4C-1421-4A79-86C3-8880174496BC wds:Q57086097-D748385C-59C4-46CD-A017-5B744C028502 wds:Q57086097-E275C84B-2761-410C-B744-9D0792AA689A wds:Q57086097-EB88EBDA-E18B-4A44-BB32-F6675B602EAA wds:Q57086097-EF92B74B-9F6A-48E0-B604-4B50C97B3BF0 wds:Q57086097-FF17F0EE-9C80-4B3B-BB79-4846B34819DA
cites work	Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage. Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) production Inducible cyclooxygenase may have anti-inflammatory properties Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis IL-1-induced nitric oxide inhibits chondrocyte proliferation via PGE2. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide. Evaluation of the influence of prostaglandin E2 on recombinant equine interleukin-1beta-stimulated matrix metalloproteinases 1, 3, and 13 and tissue inhibitor of matrix metalloproteinase 1 expression in equine chondrocyte cultures Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1) Induction of apoptosis in bovine articular chondrocyte by prostaglandin E(2) through cAMP-dependent pathway Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association Prostaglandin signaling in the renal collecting duct: release, reuptake, and oxidation in the same cell Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Cyclooxygenase-2 and prostaglandins in articular tissues PGE2 signal through EP2 promotes the growth of articular chondrocytes. Effects of prostaglandins on deoxyribonucleic acid and aggrecan synthesis in the RCJ 3.1C5.18 chondrocyte cell line: role of second messengers Simultaneous stimulation of EP2 and EP4 is essential to the effect of prostaglandin E2 in chondrocyte differentiation Modulation of glucocorticoid receptor expression in human articular chondrocytes by cAMP and prostaglandins The effect of tumor necrosis factor alpha and gamma-interferon on the resorption of human articular cartilage and on the production of prostaglandin E and of caseinase activity by human articular chondrocytes Prostaglandin E2 stimulates p53 transactivational activity through specific serine 15 phosphorylation in human synovial fibroblasts. Role in suppression of c/EBP/NF-kappaB-mediated MEKK1-induced MMP-1 expression The contributions of cyclooxygenase-2 to tumor angiogenesis Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions. PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling. Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study Prostaglandins E2 and E1 inhibit cytokine-induced metalloprotease expression in human synovial fibroblasts. Mediation by cyclic-AMP signalling pathway Is COX-2 a perpetrator or a protector? Selective COX-2 inhibitors remain controversial. A cyclic adenosine 3',5'-monophosphate signal is required for the induction of IL-1 beta by TNF-alpha in human monocytes. Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation. Prostaglandin E2 stimulates incorporation of proline into collagenase digestible proteins in human articular chondrocytes: identification of an effector autocrine loop involving insulin-like growth factor I Influence of prostaglandins on DNA and matrix synthesis in growth plate chondrocytes Induction of cyclooxygenase by interleukin 1: comparative study between human synovial cells and chondrocytes The effect of prostaglandin E2 on costochondral chondrocyte differentiation is mediated by cyclic adenosine 3',5'-monophosphate and protein kinase C Immunolocalization of low-affinity prostaglandin E receptors, EP and EP, in adult human epidermis Nutraceutical fatty acids as biochemical and molecular modulators of skeletal biology Prostaglandin E1 inhibits collagenase gene expression in rabbit synoviocytes and human fibroblasts
author name string	wds:Q57086097-199B8D72-914F-4510-9461-907D0DD17942 wds:Q57086097-783C88EE-35D2-4856-94A4-A89A91675AE5 wds:Q57086097-8FE89D9A-9A5C-475B-B671-E8B6BDD8DDC0 wds:Q57086097-977769A5-E36C-49F3-9BAA-EBEBA7F48E0F
author name string	A Robin Poole John Antoniou David J Zukor John A Di Battista
rdfs:label	Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte h (en) Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte h (nl)
skos:prefLabel	Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte h (en)

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