About: A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization

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About: A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization Goto Sponge NotDistinct Permalink

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scientific article published on 01 July 2003

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в липні 2003 (uk) im Juli 2003 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en xunetu de 2003 (ast) scientific article published on 01 July 2003 (en)
publication date	wds:Q56982335-B03A6D9B-9361-4542-9697-6144C6834AA4
publication date	2003-07-01 00:00:00Z (xsd:dateTime)
author name string	wds:Q56982335-341ACE80-7FE1-44F8-8E8E-B07ECDCA32AE wds:Q56982335-6E8DB84A-10EE-4E8A-B42F-FE8E2A5DB6C4 wds:Q56982335-7410312A-69A2-4AFD-93D0-996DF215DF9D wds:Q56982335-83BFA902-4887-4F3D-85FF-69DD87DA81A8 wds:Q56982335-AC242730-1D83-42F7-8D80-7C2B21A4820C wds:Q56982335-E8879688-254D-4D89-BC95-2F155E63901D wds:Q56982335-F42AE86D-2057-49E3-A69C-6D5F6BA7B45F wds:Q56982335-F76406F1-0EFA-4931-AEFB-94F76BD457BF
author name string	Heribert Schunkert Zahurul A Bhuiyan Marcel M A M Mannens Connie R Bezzina Hanno L Tan Ronald Wilders Tamara T Koopmann Andreas Jeron
rdfs:label	A common polymorphism in KCNH2 (nl) A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization (en)
skos:prefLabel	A common polymorphism in KCNH2 (nl) A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization (en)
name	A common polymorphism in KCNH2 (nl) A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization (en)
author	wds:Q56982335-1F1DA1F4-D1F6-4BD1-8954-FDCF81F576B9 wds:Q56982335-28A1A123-F7A0-423C-ACED-6DBB4F5CE085 wds:Q56982335-5ACC3180-84FF-4898-9F1C-CA6A17081F25 wds:Q56982335-A5180511-3B30-41E5-B240-E64841EC9B9C wds:Q56982335-E332FDAE-A416-462E-9058-215AFCDE5A87
author	Arthur Wilde Andreas Busjahn Jeanette Erdmann Friedrich C. Luft Arie O. Verkerk
title	wds:Q56982335-4B10C6B0-E7EF-479A-8FA0-2848B7A28813
title	A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization (en)
page(s)	wds:Q56982335-C8EFDC05-8A29-41B6-A905-AB1E5DBAA35D
page(s)	27-36
instance of	wds:Q56982335-40C56567-1818-4107-AC6B-09CE4BCD59DC
instance of	scholarly article
PubMed ID	wds:Q56982335-14998529-02EF-4D44-B754-4FD5E659B2CE
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12829173
PubMed ID	12829173
published in	wds:Q56982335-69074506-F60C-41B6-8A92-6B2B8E9CCFAD
published in	Cardiovascular Research
issue	wds:Q56982335-E939F6B2-4503-4872-9AF5-8FE14259409A
volume	wds:Q56982335-7B2FC7D0-4187-47AA-A238-D41DD95C0C5B
issue	1
volume	59
DOI	wds:Q56982335-87E2DF35-CC51-484F-9D09-7E0478C8C510
DOI	http://dx.doi.org/10.1016/S0008-6363(03)00342-0
DOI	10.1016/S0008-6363(03)00342-0
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q56982335
is cites work of	The primary arrhythmia syndromes: same mutation, different manifestations. Are we starting to understand why? Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies The human ERG1 channel polymorphism, K897T, creates a phosphorylation site that inhibits channel activity Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene Determinants of incomplete penetrance and variable expressivity in heritable cardiac arrhythmia syndromes Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death. Common variants at ten loci modulate the QT interval duration in the QTSCD Study Common candidate gene variants are associated with QT interval duration in the general population Common variants at ten loci influence QT interval duration in the QTGEN Study Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization Long QT syndrome: beyond the causal mutation Common variants in cardiac ion channel genes are associated with sudden cardiac death The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG) Common genetic variation modulating cardiac ECG parameters and susceptibility to sudden cardiac death. A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response A common single nucleotide polymorphism can exacerbate long-QT type 2 syndrome leading to sudden infant death. A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization Protective effect of KCNH2 single nucleotide polymorphism K897T in LQTS families and identification of novel KCNQ1 and KCNH2 mutations Functional significance of KCNH2 (HERG) K897T polymorphism for cardiac repolarization assessed by analysis of T-wave morphology. Long QT syndrome: reduced repolarization reserve and the genetic link Cardiac repolarisation and drug regulation: assessing cardiac safety 10 years after the CPMP guidance Drug-induced spatial dispersion of repolarization Pharmacogenetic aspects of drug-induced torsade de pointes: potential tool for improving clinical drug development and prescribing Determinants of prolonged QT interval and their contribution to sudden death risk in coronary artery disease: the Oregon Sudden Unexpected Death Study Association of KCNQ1, KCNE1, KCNH2 and SCN5A polymorphisms with QTc interval length in a healthy population Drug- and non-drug-associated QT interval prolongation Overlapping LQT1 and LQT2 phenotype in a patient with long QT syndrome associated with loss-of-function variations in KCNQ1 and KCNH2 KCNQ1 p.L353L affects splicing and modifies the phenotype in a founder population with long QT syndrome type 1. Molecular analysis of potassium ion channel genes in sudden death cases among patients administered psychotropic drug therapy: are polymorphisms in LQT genes a potential risk factor? Individual QT-R-R relationship: average stability over time does not rule out an individual residual variability: implication for the assessment of drug effect on the QT interval. Congenital long QT syndromes: clinical features, molecular genetics and genetic testing Long QT syndrome. Why does sex matter? Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels Muscle channelopathies and critical points in functional and genetic studies Contribution of long-QT syndrome genetic variants in sudden infant death syndrome Cardiac ion channel gene mutations in sudden infant death syndrome Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG Confirmation of associations between ion channel gene SNPs and QTc interval duration in healthy subjects Relationship of common candidate gene variants to electrocardiographic T-wave peak to T-wave end interval and T-wave morphology parameters

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