About: Lennart Mucke

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An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

medical researcher

Attributes	Values
rdf:type	Item
description	forskare (sv) ikertzailea (eu) 研究者 (ja) araştırmacı (tr) wetenschapper (nl) изилдөөчү (ky) medical researcher (en) медичний дослідник (uk)
rdfs:label	Lennart Mucke (en) Lennart Mucke (es) Lennart Mucke (nl) Lennart Mucke (sq) Lennart Mucke (ast)
skos:prefLabel	Lennart Mucke (en) Lennart Mucke (es) Lennart Mucke (nl) Lennart Mucke (sq) Lennart Mucke (ast)
name	Lennart Mucke (en) Lennart Mucke (es) Lennart Mucke (nl) Lennart Mucke (sq) Lennart Mucke (ast)
Scopus author ID	wds:Q56825889-59a0f5e1-4e77-3986-e765-ffaf55bd7585
Scopus author ID	7005734127
given name	wds:Q56825889-DA009DE0-FC6F-4005-BB7B-48A8A42AB690
given name	Lennart
instance of	wds:Q56825889-b58a1c7b-4ce4-709a-ed08-b4fb1bebe511
instance of	Homo sapiens
award received	wds:Q56825889-343f12a1-41fb-498b-680c-8666d72f8b30 wds:Q56825889-72cd8d46-4c34-2013-adf8-43dde8c37c83 wds:Q56825889-ad9f33fb-4b43-0382-9115-ddbf97fedbda
award received	Potamkin Prize Metlife Foundation Award for Medical Research in Alzheimer's Disease Khalid Iqbal Lifetime Achievement Award in Alzheimer’s Disease Research
occupation	wds:Q56825889-A9451972-BD66-4637-921B-B511D18E9FB0 wds:Q56825889-FCD98044-DB22-472D-AA34-B312369FED99
employer	wds:Q56825889-49186AF1-A4D0-4B68-9EA2-FC3C54C2812F wds:Q56825889-522dbab1-4475-8366-02bc-d46ddc00b736
occupation	researcher medical researcher
employer	Gladstone Institutes University of California, San Francisco
ORCID iD	wds:Q56825889-01C1AE45-02F0-4BE3-B62A-7EF0A0867DF5
ORCID iD	https://orcid.org/0000-0001-6256-9559
ORCID iD	0000-0001-6256-9559
is owl:sameAs of	Lennart Mucke
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q56825889
is author of	High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models A network dysfunction perspective on neurodegenerative diseases Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease. Reversing EphB2 depletion rescues cognitive functions in Alzheimer model RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice Epilepsy and cognitive impairments in Alzheimer disease Ibuprofen, inflammation and Alzheimer disease. Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology The many faces of tau Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. Tau reduction prevents disease in a mouse model of Dravet syndrome Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling 100 years and counting: prospects for defeating Alzheimer's disease Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6 Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli Collagen VI protects neurons against Abeta toxicity Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease Amyloid protein precursor stimulates excitatory amino acid transport. Implications for roles in neuroprotection and pathogenesis Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice. Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie Expression of cathepsin G-like and α1-antichymotrypsin-like proteins in reactive astrocytes Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Apolipoprotein E and cognitive performance Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β Alzheimer mechanisms and therapeutic strategies Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. Tau reduction prevents Abeta-induced defects in axonal transport. Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice Inflammation in neurodegenerative disease--a double-edged sword Neurotrophic and neuroprotective effects of hAPP in transgenic mice A roadmap for the prevention of dementia II: Leon Thal Symposium 2008. Alzheimer's disease: A prion protein connection. High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease Hypothalamic-pituitary-adrenal dysfunction in Apoe(-/-) mice: possible role in behavioral and metabolic alterations. Androgens protect against apolipoprotein E4-induced cognitive deficits

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