About: Fuzhisan, a Chinese herbal medicine, inhibits beta-amyloid-induced neurotoxicity and tau phosphorylation through calpain/Cdk5 pathway in cultured cortical neurons

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About: Fuzhisan, a Chinese herbal medicine, inhibits beta-amyloid-induced neurotoxicity and tau phosphorylation through calpain/Cdk5 pathway in cultured cortical neurons Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Item
description	article (en) ലേഖനം (ml) wetenschappelijk artikel (nl) наукова стаття, опублікована в травні 2011 (uk) article scientifique publié en 2011 (fr) im Mai 2011 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q56558091-6431ED00-591F-46E1-AF6C-AB5EF83D6E61
publication date	2011-05-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q56558091-51FD8551-DADB-49B4-9D2D-1F3D1A0DFF4E
language of work or name	English
exact match	wds:Q56558091-0DA6D7B2-E332-4B54-ABA3-8DD48394313E
exact match	https://scigraph.springernature.com/pub.10.1007/s11064-011-0405-6
cites work	wds:Q56558091-00E879A4-D5F0-4378-A934-FB236AF00400 wds:Q56558091-019E9943-9D0E-40A1-950C-0D930D16A7F6 wds:Q56558091-058F263E-4BBE-4996-AC12-5E04FAC8AE35 wds:Q56558091-0CC9CF30-A1BE-4F6E-AF3A-7564763DD23C wds:Q56558091-1C1FEC26-55EC-45B7-9351-F5BEA9419673 wds:Q56558091-2C95597B-D131-4B32-B0B3-36BD14713E46 wds:Q56558091-384A6BE5-D265-4E2F-8B14-94E7EE2F427C wds:Q56558091-39B4EE1F-70CD-405C-9F10-94683DDFCAA8 wds:Q56558091-3D84BAEB-E277-4F08-929F-DA9F41E21E73 wds:Q56558091-4886BB79-5F67-474C-94F8-D3D984FFF850 wds:Q56558091-4AA2FD46-193F-4CC7-88BD-226D6DEF0470 wds:Q56558091-4D0961DE-4D08-485A-B791-CF00C89F7A1F wds:Q56558091-501ADBEF-E6D6-47FD-B920-4887605CA6BB wds:Q56558091-50B1DB52-8812-4587-B784-A68BEEF396A5 wds:Q56558091-5D304852-635C-462A-A335-967A880A6EB3 wds:Q56558091-5E059F51-481B-49BF-8F4C-0A207A950428 wds:Q56558091-73E12D2B-5569-4E00-B678-4655FA531949 wds:Q56558091-7F3A7742-DA3E-45D2-8231-A6830336B369 wds:Q56558091-85E86076-EF13-44C9-8AFA-C48BDC4A9E24 wds:Q56558091-8C97878E-582F-4E95-AD17-B598317F3702 wds:Q56558091-8D81BCD7-9FFA-4539-AADA-B1F4D30C5212 wds:Q56558091-8FC7E9C2-84A7-49F3-BB9B-84796E746F26 wds:Q56558091-92DA6B29-939A-4DCE-80DE-4EF7467B6CD1 wds:Q56558091-9A8A8CCC-6073-465C-974D-AEA4A3E75062 wds:Q56558091-9B7FE960-9D19-4E33-877F-F26B1A5AAB5D wds:Q56558091-9D9B4A69-72D4-4C64-B961-31ECD0DE339E wds:Q56558091-A3265A53-7DE7-4076-9B69-E4DB2E8DAA1F wds:Q56558091-A9F01775-6417-4D4E-8D92-F45B6900ED5B wds:Q56558091-AC6301F4-45C8-4A66-A522-D64E60C1F94C wds:Q56558091-B09E2FD6-8EB2-47F3-8BAB-12EAC2538CCD wds:Q56558091-B32BF53C-3F0C-4020-BD75-13827D6E0B35 wds:Q56558091-BC35CF2A-A07C-4E62-995B-17AD414240EC wds:Q56558091-CF565278-42AF-4531-9796-F5DA7A90DF79 wds:Q56558091-D338BA52-FC2A-4EED-83A9-C58F014EE13A wds:Q56558091-E586C117-EEF8-4381-ABB7-943139779E48 wds:Q56558091-F525687D-84D0-467B-9947-8313C4DC244F wds:Q56558091-FDB3F967-8BC1-46ED-98CF-379D353FA0D0
cites work	Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments Calcium dysregulation in Alzheimer's disease Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules Tau is essential to beta -amyloid-induced neurotoxicity The carboxyl third of tau is tightly bound to paired helical filaments. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles A decade of CDK5. Alzheimer's disease: a central role for amyloid beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease Evidence of calpain/cdk5 pathway inhibition by lithium in 3-nitropropionic acid toxicity in vivo and in vitro Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration Neurotoxicity induces cleavage of p35 to p25 by calpain Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death. Cdk5: mediator of neuronal death and survival Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain. Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases beta-amyloid toxicity in cortical neurons. An unusual member of the Cdk family: Cdk5. Cyclin-dependent kinase 5 activator p35 over-expression and amyloid beta synergism increase apoptosis in cultured neuronal cells. Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein Beta-amyloid-induced neurotoxicity of a hybrid septal cell line associated with increased tau phosphorylation and expression of beta-amyloid precursor protein A Cdk5-p35 stable complex is involved in the beta-amyloid-induced deregulation of Cdk5 activity in hippocampal neurons A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthase kinase-3. Analysis of fuzhisan and quantitation of baicalin and ginsenoside Rb(1) by HPLC-DAD-ELSD. Neurodegeneration in an Aβ-induced model of Alzheimer’s disease: the role of Cdk5 Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death. Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation Effects of Chinese herbal medicine fuzhisan on aged rats N-acetylcysteine prevents beta-amyloid toxicity by a stimulatory effect on p35/cyclin-dependent kinase 5 activity in cultured cortical neurons Increased expression of cdk5/p25 in N2a cells leads to hyperphosphorylation and impaired axonal transport of neurofilament proteins Microtubule-associated protein tau, paired helical filaments, and phosphorylation.
author name string	wds:Q56558091-93248E1E-4137-495A-8CE2-667897A8ADFC wds:Q56558091-9792FFA9-37B2-456E-AF20-216694D640A4 wds:Q56558091-A66EEA0D-478E-428D-BACE-617AF618A2C7 wds:Q56558091-ADC7F59D-D132-4915-903E-B292B6A8FCF8 wds:Q56558091-E22D5FC8-EB4C-459A-B274-8A8E48062379 wds:Q56558091-F2DB8653-ADF4-48E0-9DDD-A44A28FBE7AF
author name string	Ying Tang Jiping Qi Desheng Wang Ruiping Zhao Shirong Wen Zhaoxu Zhang
rdfs:label	Fuzhisan, a Chinese herbal medicine, inhibits beta-amyloid-induced neurotoxicity and tau phosphorylation through calpain/Cdk5 pathway in cultured cortical neurons (en)

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