About: Stephen S. Taylor

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An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

British cancer researcher

Attributes	Values
rdf:type	Item
description	연구원 (ko) গবেষক (bn) 研究者 (ja) дослідник (uk) изилдөөчү (ky) 研究者 (zh) հետազոտող (hy) hulumtues (sq) onderzoeker (nl) British cancer researcher (en)
rdfs:label	Stephen S. Taylor (de) Stephen S. Taylor (en) Stephen S. Taylor (es) Stephen S. Taylor (fr) Stephen S. Taylor (it) Stephen S. Taylor (nl) Stephen S. Taylor (pt) Stephen S. Taylor (pt-br) Stephen S. Taylor (ast) Stephen S. Taylor (gl) Stephen S. Taylor (sl) Stephen S. Taylor (tr) স্টিভেন এস টেলর (bn)
skos:prefLabel	Stephen S. Taylor (de) Stephen S. Taylor (en) Stephen S. Taylor (es) Stephen S. Taylor (fr) Stephen S. Taylor (it) Stephen S. Taylor (nl) Stephen S. Taylor (pt) Stephen S. Taylor (pt-br) Stephen S. Taylor (ast) Stephen S. Taylor (gl) Stephen S. Taylor (sl) Stephen S. Taylor (tr) স্টিভেন এস টেলর (bn)
name	Stephen S. Taylor (de) Stephen S. Taylor (en) Stephen S. Taylor (es) Stephen S. Taylor (fr) Stephen S. Taylor (it) Stephen S. Taylor (nl) Stephen S. Taylor (pt) Stephen S. Taylor (pt-br) Stephen S. Taylor (ast) Stephen S. Taylor (gl) Stephen S. Taylor (sl) Stephen S. Taylor (tr) স্টিভেন এস টেলর (bn)
Scopus author ID	wds:Q47814643-458A7C2A-4B49-4623-8C9E-E40ED8412606
AE member ID	wds:Q47814643-487AE3E7-B973-414E-AFF1-805C5BA6BD03
Scopus author ID	35402832700
AE member ID	Taylor_Stephen
given name	wds:Q47814643-73BAF586-71F0-4EEB-916D-C4D1AF8F78FE
given name	Stephen
instance of	wds:Q47814643-4A13395D-37DB-44C8-BFA4-4D1BFECE4C14
instance of	Homo sapiens
skos:altLabel	Stephen Taylor (en)
occupation	wds:Q47814643-4768A6EB-A183-4F10-A6A4-08FB5460F51D
employer	wds:Q47814643-d7bd695d-46b0-c19e-b33b-805714f540d5
sex or gender	wds:Q47814643-9951FAE1-C6EC-4C2C-B151-CB6F6097A443
country of citizenship	wds:Q47814643-1f889847-4da0-8a4d-c111-b101a4263938
member of	wds:Q47814643-FCE425BD-E499-40FD-A1A6-78119F61054A
educated at	wds:Q47814643-79e6f208-47d6-8796-276e-cb407e568f85 wds:Q47814643-8360f6e7-436c-242a-b969-9dc5cef0525d
family name	wds:Q47814643-805814BF-B8E5-4A9A-A7ED-B9D49990C1F1
occupation	cancer researcher
employer	Manchester Cancer Research Centre
sex or gender	male
country of citizenship	United Kingdom
member of	Academia Europaea
educated at	University of Manchester University of Oxford
family name	Taylor
ORCID iD	wds:Q47814643-16CEFEAF-C00B-48D6-A8C2-D1B8A18BECE4
ORCID iD	https://orcid.org/0000-0003-4621-9326
ORCID iD	0000-0003-4621-9326
is owl:sameAs of	Stephen S. Taylor
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q47814643
is author of	How do anti-mitotic drugs kill cancer cells? MYC Is a Major Determinant of Mitotic Cell Fate Sgo1 establishes the centromeric cohesion protection mechanism in G2 before subsequent Bub1-dependent recruitment in mitosis. Aneuploid colon cancer cells have a robust spindle checkpoint Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol. Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20. Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine The Aurora B kinase activity is required for the maintenance of the differentiated state of murine myoblasts. The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. Silencing Cenp-F weakens centromeric cohesion, prevents chromosome alignment and activates the spindle checkpoint. Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes GSK-3 inhibitors induce chromosome instability Bub1 maintains centromeric cohesion by activation of the spindle checkpoint Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores. The spindle assembly checkpoint Validating Aurora B as an anti-cancer drug target.

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