About: Jeroen E Guikema

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An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

researcher

Attributes	Values
rdf:type	Item
description	forskare (sv) ikertzailea (eu) researcher (en) 연구원 (ko) গবেষক (bn) 研究者 (ja) ഗവേഷകൻ (ml) wetenschapper (nl) дослідник (uk) वैज्ञानिक (hi) изилдөөчү (ky) 研究者 (zh) հետազոտող (hy) hulumtues (sq)
rdfs:label	Jeroen E Guikema (en) Jeroen E Guikema (es) Jeroen E Guikema (nl) Jeroen E Guikema (sl) Jeroen E Guikema (ast) Jeroen E. Guikema (it)
skos:prefLabel	Jeroen E Guikema (en) Jeroen E Guikema (es) Jeroen E Guikema (nl) Jeroen E Guikema (sl) Jeroen E Guikema (ast) Jeroen E. Guikema (it)
name	Jeroen E Guikema (en) Jeroen E Guikema (es) Jeroen E Guikema (nl) Jeroen E Guikema (sl) Jeroen E Guikema (ast) Jeroen E. Guikema (it)
given name	wds:Q42384449-D57BF39F-01E6-4BF6-A7F9-454D8F05D608
given name	Jeroen
instance of	wds:Q42384449-A47741FE-A4AF-4514-B740-76AC67F74FF7
instance of	Homo sapiens
Loop ID	wds:Q42384449-AD8C674F-0B0F-4334-A8F7-949F516EB777
Loop ID	406406
skos:altLabel	Jeroen Guikema (en)
occupation	wds:Q42384449-115D2826-4BE9-4805-A5E1-40D826D23864
employer	wds:Q42384449-BC07D009-9490-486D-B072-C897A5BC534C
sex or gender	wds:Q42384449-CAE8C6A1-E79C-4996-A7F3-B9B36D880800
VIAF ID	wds:Q42384449-ae97d2ed-14a3-42df-b4c4-a2c5b81a5c0e
GND ID	wds:Q42384449-5267f145-f62a-4388-b5fd-6211d28559da
educated at	wds:Q42384449-5781CF32-C07C-44D0-9E9E-35D26ED271A0
VIAF ID	http://viaf.org/viaf/6273162906478778110001
GND ID	https://d-nb.info/gnd/1238627226
occupation	researcher
employer	Worcester Foundation for Biomedical Research
sex or gender	male
VIAF ID	6273162906478778110001
GND ID	1238627226
educated at	University of Groningen
ORCID iD	wds:Q42384449-3882B115-F69C-40D9-AE2A-4B84342399F6
Dimensions author ID	wds:Q42384449-E8FF3842-28FD-464A-B42C-14A173757D1E
ORCID iD	https://orcid.org/0000-0001-6894-3441
ORCID iD	0000-0001-6894-3441
Dimensions author ID	01010433177.10
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q42384449
is author of	Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells Myeloma clonotypic B cells are hampered in their ability to undergo B-cell differentiation in vitro Mechanism and regulation of class switch recombination APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination. Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair. Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge. ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination. Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model. CD27 is heterogeneously expressed in multiple myeloma: low CD27 expression in patients with high-risk disease. Identification of a novel stereotypic IGHV4-59/IGHJ5-encoded B-cell receptor subset expressed by various B-cell lymphomas with high affinity rheumatoid factor activity. A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi. Mobilized human CD34+ hematopoietic stem cells enhance tumor growth in a nonobese diabetic/severe combined immunodeficient mouse model of human non-Hodgkin's lymphoma NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling Expression of activation-induced cytidine deaminase is confined to B-cell non-Hodgkin's lymphomas of germinal-center phenotype Complex biallelic IGH rearrangements in IgM-expressing Z-138 cell line: Involvement of downstream immunoglobulin class switch recombination. Multiple myeloma related cells in patients undergoing autologous peripheral blood stem cell transplantation. Autologous stem cell transplantation in multiple myeloma after VAD and EDAP courses: a high incidence of oligoclonal serum Igs post transplantation Computational Model Reveals Limited Correlation between Germinal Center B-Cell Subclone Abundancy and Affinity: Implications for Repertoire Sequencing Chronic lymphocytic leukemia development is accelerated in mice with deficiency of the pro-apoptotic regulator NOXA. Quantitative RT-PCR analysis of activation-induced cytidine deaminase expression in tissue samples from mantle cell lymphoma and B-cell chronic lymphocytic leukemia patients CD27-triggering on primary plasma cell leukaemia cells has anti-apoptotic effects involving mitogen activated protein kinases. Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay. Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins. The role of Apex2 in class-switch recombination of immunoglobulin genes Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells. A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching. In vitro induction of antibody secretion of primary B-cell chronic lymphocytic leukaemia cells Structure and consequences of IGH switch breakpoints in Burkitt lymphoma. Stereotypic rheumatoid factors that are frequently expressed in mucosa-associated lymphoid tissue-type lymphomas are rare in the labial salivary glands of patients with Sjögren's syndrome. Heterogeneity in the multiple myeloma tumor clone. APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains. H2AX is not affected in mantle cell lymphoma with 11q23 deletion Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer. The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma Consensus strategy to quantitate malignant cells in myeloma patients is validated in a multicenter study. Belgium-Dutch Hematology-Oncology Group ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.

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