About: The systems biology approach to drug development: application to toxicity assessment of cardiac drugs

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scientific article published on 02 June 2010

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description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2010 (ast) наукова стаття, опублікована в червні 2010 (uk) scientific article published on 02 June 2010 (en) مقالة علمية نشرت في 02 يونيو 2010 (ar)
publication date	wds:Q37762441-2FB4D9CB-1050-43AD-9B9A-DAF535204B2B
publication date	2010-06-02 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37762441-22B19ADB-09A9-4AD1-802D-F223E3E8E3FF
language of work or name	English
cites work	wds:Q37762441-03AD9B7E-854A-4B3E-8526-31DE78A1DADD wds:Q37762441-0920BC1D-BDB5-4597-A6D9-421F0B5BF58E wds:Q37762441-11CD513A-21F2-4153-ABAE-57BFA266C0B7 wds:Q37762441-1221E915-3458-4977-921A-865C790428AD wds:Q37762441-15E802B7-8DCE-46AA-A790-2BAAA595D839 wds:Q37762441-17B7AA2E-5D8E-4776-A751-0BC55F514C79 wds:Q37762441-1897169C-7150-4115-AE66-80762BFC63BE wds:Q37762441-1A61ECA2-D75F-4B63-8929-A5CD27E41813 wds:Q37762441-289753CE-53A3-4B7D-B434-B55CAC24DADC wds:Q37762441-37AF8BA2-F961-4E13-9392-A2422A01B0B4 wds:Q37762441-3D43768C-4D69-4A1B-A428-27175C4A5200 wds:Q37762441-493A05F2-6FE4-4510-8D68-147018955FD7 wds:Q37762441-4B729381-6EF8-4B5E-B4DE-6166EC562783 wds:Q37762441-54D79279-A4F2-4E55-B003-2435391B7C6A wds:Q37762441-550587CE-3A6E-4354-90C6-83B347FAC158 wds:Q37762441-58921755-350D-429E-A9FC-4E68C221B676 wds:Q37762441-60A6D709-01F6-4688-90D3-A45325F0E734 wds:Q37762441-6428B26A-2DF2-4AB4-99F5-D8EFD704950D wds:Q37762441-8189D7FF-6832-47C7-A1DD-02A5B244DFD2 wds:Q37762441-91832FAD-F935-4C33-860F-86E6E5A59C1E wds:Q37762441-AE616136-15B5-4125-906D-078996AB9E99 wds:Q37762441-D471576A-9CF4-4D9F-9403-43A1B54599D3 wds:Q37762441-DE86F269-E3F2-49BD-ACF2-4CC653FAE8AF wds:Q37762441-E6060406-46AE-4754-A4E5-CC2BABAB60D0 wds:Q37762441-F09BCF0F-19B6-4EA7-B18C-EFE47C1DCB6C
cites work	Chaste: A test-driven approach to software development for biological modelling Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function Three-dimensional models of individual cardiac histoanatomy: tools and challenges Multiscale modelling of drug-induced effects on cardiac electrophysiological activity Calsequestrin-mediated mechanism for cellular calcium transient alternans Sex, age, and regional differences in L-type calcium current are important determinants of arrhythmia phenotype in rabbit hearts with drug-induced long QT type 2 Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome Sex-based transmural differences in cardiac repolarization and ionic-current properties in canine left ventricles. Feedback remodeling of cardiac potassium current expression: a novel potential mechanism for control of repolarization reserve Towards predictive modelling of the electrophysiology of the heart Reciprocal role of the inward currents ib, Na and i(f) in controlling and stabilizing pacemaker frequency of rabbit sino-atrial node cells A new interpretation of the pace-maker current in calf Purkinje fibres Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres Impact of ionic current variability on human ventricular cellular electrophysiology. Generation of histo-anatomically representative models of the individual heart: tools and application Computational models of the heart and their use in assessing the actions of drugs Binomial leap methods for simulating stochastic chemical kinetics. Differences between left and right ventricular chamber geometry affect cardiac vulnerability to electric shocks A BEAUTIFUL lesson--ivabradine protects from ischaemia, but not from heart failure: through heart rate reduction or more? Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: from experiments to computer simulations Dimensionality in cardiac modelling The role of photon scattering in optical signal distortion during arrhythmia and defibrillation Parameter sensitivity analysis in electrophysiological models using multivariable regression The BEAUTIFUL study: randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction - baseline characteristics of the study population
author name string	wds:Q37762441-CAFA79A5-BBF8-4A3E-8ADB-B6E97D8BDD37
author name string	D Noble
rdfs:label	The systems biology approach to drug development: application to toxicity assessment of cardiac drugs (en) The systems biology approach to drug development: application to toxicity assessment of cardiac drugs (nl) The systems biology approach to drug development: application to toxicity assessment of cardiac drugs (ast)
skos:prefLabel	The systems biology approach to drug development: application to toxicity assessment of cardiac drugs (en) The systems biology approach to drug development: application to toxicity assessment of cardiac drugs (nl) The systems biology approach to drug development: application to toxicity assessment of cardiac drugs (ast)
name	The systems biology approach to drug development: application to toxicity assessment of cardiac drugs (en) The systems biology approach to drug development: application to toxicity assessment of cardiac drugs (nl) The systems biology approach to drug development: application to toxicity assessment of cardiac drugs (ast)
author	wds:Q37762441-3482BD8D-95EF-4275-B488-7BE74A29F012 wds:Q37762441-547E370A-0779-4A4C-8154-88CC8C8EC8AC wds:Q37762441-74FBAF54-620F-40B4-BCC9-EF5E3F604EC9 wds:Q37762441-8FF4F84E-3482-4BD8-8A5A-F5EBEB755A06 wds:Q37762441-A7413CCB-3443-40F1-BB6C-0E83218D04BA
author	David Gavaghan Peter Kohl Blanca Rodriguez Kevin Burrage Vicente Grau
title	wds:Q37762441-49E1855D-C145-41C7-8B40-F439961CABB6
title	The systems biology approach to drug development: application to toxicity assessment of cardiac drugs (en)
page(s)	wds:Q37762441-5CB5B764-ECDD-4CAC-84BB-E2AC5E2C35CD
page(s)	130-134
instance of	wds:Q37762441-4253c270-4b42-4cfd-ab33-1200c1e0bd42 wds:Q37762441-C7CF0AF3-E6D2-4AC0-9F60-00D3185B04C1
instance of	review article scholarly article

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