About: Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells.

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About: Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells. Goto Sponge NotDistinct Permalink

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scientific article published on 16 September 2016

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2016 (ast) наукова стаття, опублікована у вересні 2016 (uk) scientific article published on 16 September 2016 (en) مقالة علمية نشرت في 16 سبتمبر 2016 (ar)
publication date	wds:Q37688903-56C81193-97CE-4086-BD8F-0216FEFFBA5D
publication date	2016-11-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37688903-838D74E1-F908-4FF3-BD93-0FD5A4A29894
language of work or name	English
cites work	wds:Q37688903-02EDF4C7-98CC-4E1F-B840-A905B1C189D9 wds:Q37688903-0A347CA0-895A-480A-A8C4-F83692B12F59 wds:Q37688903-0ECED15A-E0F9-4969-B492-77BAA83F98A4 wds:Q37688903-12C80D3D-1C07-4606-A4C4-4DDC786959F2 wds:Q37688903-177ADA51-AFD1-49E1-8CFC-374EBF3FE0C5 wds:Q37688903-1916551A-CB80-49DF-BB06-C88F7EAA6141 wds:Q37688903-22C47018-2C1B-44FF-9767-BBC1D7AC4CA1 wds:Q37688903-23655B5C-431B-491D-BBC7-1CA0577FE109 wds:Q37688903-259B0315-462B-4396-9352-EED4A3A92DC0 wds:Q37688903-403FF1E9-0248-4E2E-8560-81686BAAB00C wds:Q37688903-4B4C7FE7-CE52-43F7-A5F4-CB31D5A5EB1C wds:Q37688903-55FB1DD7-89F8-413A-865C-6B0B12C3ABB5 wds:Q37688903-5B7994A4-EFC4-4C5A-8204-E277897FF5F6 wds:Q37688903-5D38F830-090E-4AC6-8353-4CA27A0BA0BC wds:Q37688903-5F318C2F-64C8-4453-AFA9-285B9CA6566F wds:Q37688903-6412D7CB-8EEC-4D35-95DC-E3D0BC24559D wds:Q37688903-6A64C100-C41C-4342-9D00-33D7D7B2A2C1 wds:Q37688903-721A3DC4-93DC-4414-935A-112EE334656E wds:Q37688903-7BC398B3-131E-4A15-B746-C9AAB8FAAEDF wds:Q37688903-92012EB8-3824-4537-8C41-86ACF3A79AAA wds:Q37688903-961C3D25-D9C0-46D9-84CA-C562461FB000 wds:Q37688903-9F67C016-D396-4C60-9A6A-13E3CBDC7FE2 wds:Q37688903-A4EC87C9-C28E-4845-8FC4-93660FBD30E7 wds:Q37688903-A98EA2CD-F3C2-4F19-8B8B-F7318F258128 wds:Q37688903-D145001A-DCDB-44CE-9C0E-C941BA11E469 wds:Q37688903-D1F4BCC8-3089-4937-83A7-D7370A52FF7F wds:Q37688903-D9CBCFA9-05E3-4246-B291-BF951F64A8A4 wds:Q37688903-E48E6AAE-02B1-4251-9D8E-6D60DEFE0259 wds:Q37688903-F4C205A5-B8C1-4971-A86D-D99BA4EC408E wds:Q37688903-F5931CA1-3854-42E5-BF73-7EDD00C111B9
cites work	FDA Approval Summary: Olaparib Monotherapy in Patients with Deleterious Germline BRCA-Mutated Advanced Ovarian Cancer Treated with Three or More Lines of Chemotherapy Cisplatin and DNA repair in cancer chemotherapy The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks The active site of the DNA repair endonuclease XPF-ERCC1 forms a highly conserved nuclease motif Purification and characterization of the XPF-ERCC1 complex of human DNA repair excision nuclease Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy. Cisplatin resistance: preclinical findings and clinical implications Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1 Pseudoirreversible inhibition of prostate-specific membrane antigen by phosphoramidate peptidomimetics Potent inhibition of human apurinic/apyrimidinic endonuclease 1 by arylstibonic acids Nuclear excision repair-based personalized therapy for non-small cell lung cancer: from hypothesis to reality Current status of excision repair cross complementing-group 1 (ERCC1) in cancer. Identification of DNA repair gene Ercc1 as a novel target in melanoma Enhanced cisplatin cytotoxicity by disturbing the nucleotide excision repair pathway in ovarian cancer cell lines. Novel role of base excision repair in mediating cisplatin cytotoxicity Identification of novel small molecule inhibitors of the XPA protein using in silico based screening Platinum-DNA interactions and subsequent cellular processes controlling sensitivity to anticancer platinum complexes Novel irreversible small molecule inhibitors of replication protein A display single-agent activity and synergize with cisplatin Multiple roles of the ERCC1-XPF endonuclease in DNA repair and resistance to anticancer drugs Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods Downregulation of XPF-ERCC1 enhances cisplatin efficacy in cancer cells. Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance A novel transcript for DNA repair gene Ercc1 in mouse skin Virtual screening and biological evaluation of inhibitors targeting the XPA-ERCC1 interaction Cisplatin: a clinical review. Part II--Nursing assessment and management of side effects of cisplatin Setting the stage for tailored chemotherapy in the management of non-small cell lung cancer Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF. N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF. Cisplatin: a clinical review. Part I--Current uses of cisplatin and administration guidelines Characterization of an inhibitory dynamic pharmacophore for the ERCC1-XPA interaction using a combined molecular dynamics and virtual screening approach.
author name string	wds:Q37688903-0076AEEC-D847-4631-BCB7-105612F35CDA wds:Q37688903-18B06FAC-C6EF-43E2-ADC0-49D400D99180 wds:Q37688903-280363CD-7D42-45C9-BB6F-6D8E8FABD7A9 wds:Q37688903-5EA231B7-012B-4EF7-B06F-8C566E3548D9 wds:Q37688903-A6FAE21F-407C-487D-A42C-D2BBF73BCB72 wds:Q37688903-AED5ED4B-6D3B-43B9-9150-9EFC3D736F78 wds:Q37688903-EB7A3F5E-FF5C-42CC-BBBD-92AA9506ADC3 wds:Q37688903-FD4C0241-240B-4CA4-95A3-4BD25D6B000B
author name string	Hao Zhang Gerold Bepler Kristin Tillison Vivian Kalman-Maltese Ashley M Floyd Sanjeevani Arora Steve M Patrick Elaine M Chalfin
rdfs:label	Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells. (en) Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells. (nl) Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells. (ast)

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