About: Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

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About: Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity Goto Sponge NotDistinct Permalink

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scientific article published on April 1985

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) bài báo khoa học (vi) article scientifique (fr) artículu científicu espublizáu en 1985 (ast) наукова стаття, опублікована у квітні 1985 (uk) 1985年學術文章 (zh) مقالة علمية نشرت في أبريل 1985 (ar) scientific article published on April 1985 (en)
publication date	wds:Q37683630-B8973725-E33C-4FFE-AE0E-5DFEB6AC2C34
publication date	1985-04-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37683630-A74EC0B5-7519-4AEF-AEBE-2A15175147B8
language of work or name	English
cites work	wds:Q37683630-02697AC8-8E8E-4B22-B12E-960EA863B24D wds:Q37683630-02BDBAA5-6B37-4648-9B7D-7859808A7A89 wds:Q37683630-08A00F07-2669-4BEE-877C-3DD23F27480D wds:Q37683630-17B408ED-A1CC-4FAC-BB04-88B3365AE989 wds:Q37683630-19F36B10-E187-4926-8AF5-24339F0BCEEA wds:Q37683630-1B6F3DA6-47D4-49EE-A4C5-349EEC80622F wds:Q37683630-22C519B7-33A6-4CC5-B58C-B2F009D5D27E wds:Q37683630-2D8B3761-9AC3-41B4-BCD6-1D13741C77CF wds:Q37683630-3C590BD7-9962-49DF-B9D1-9531EEC047E8 wds:Q37683630-419EE1DE-7F52-45DD-929E-49C836B85C84 wds:Q37683630-43211A5E-5D11-4983-88B3-475DFFAB092D wds:Q37683630-471D637A-00BD-46FD-851F-2467D0265F8A wds:Q37683630-59469D98-5FE2-43FE-97D2-B8046905CEA8 wds:Q37683630-61E5421D-F420-46AD-8263-1812574E9B9D wds:Q37683630-660C4F2F-843C-4E92-B4B1-4F7C052E2AC7 wds:Q37683630-663BCBDB-585D-4B5D-BA01-A2B8EC26F72E wds:Q37683630-6EBD2BBF-64D6-4DE3-8FDD-B20EF5F68460 wds:Q37683630-6EE31BA1-6868-47B6-9E7F-11BFCCB95F85 wds:Q37683630-7056457D-FB62-4BA3-8D69-6E91859D18D5 wds:Q37683630-763D6B34-5EBF-4A65-A3E8-0CEEEA94901F wds:Q37683630-769615FC-9A67-4E65-BAA1-7629C112E3EA wds:Q37683630-7B5D0640-462F-4792-AECB-13FDF17DEE6A wds:Q37683630-7E96F71C-D346-430C-9F03-B50CFCA1774A wds:Q37683630-85A812A4-47C3-48FF-BF8C-A40F92C0B17D wds:Q37683630-8D1AB8C2-A02A-4CDA-A4DA-C7EECB2F2FD4 wds:Q37683630-9553B1D4-F0AD-4C94-958A-D55552168383 wds:Q37683630-9600D235-BF22-4621-8B5E-C27C690DA512 wds:Q37683630-99D72BC7-808F-4A36-89E3-69C7EA0D8576 wds:Q37683630-9E4BC623-1FB8-42C5-BDA7-0827DA441B6A wds:Q37683630-A4BCE243-7D33-41D0-BA3F-A67935FCB556 wds:Q37683630-A868044D-B44C-47AA-AC23-47AED48BEEC6 wds:Q37683630-AF6DC62A-B49B-4749-8119-79EF843CC839 wds:Q37683630-CF04A20A-441F-4846-89DB-481EF4265C65 wds:Q37683630-F24839EB-8047-4691-AAF2-7AD7A128B82F wds:Q37683630-F84BA3D8-1DD4-47B2-967A-C31CFFEFFA8F
cites work	Localization of catecholamine uptake in rat brain slices. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons Chronic parkinsonism secondary to intravenous injection of meperidine analogues Protein measurement with the Folin phenol reagent Pargyline Prevents MPTP-Induced Parkinsonism in Primates Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors The brain-stem lesions in Parkinsonism Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: characterization and localization of receptor binding sites in rat and human brain Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism. Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): implications for treatment and the pathogenesis of Parkinson's disease Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis Acute administration of 1-N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a compound producing parkinsonism in humans, stimulates [2-14C]deoxyglucose uptake in the regions of the catecholaminergic cell bodies in the rat and guinea pig brains. Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey 1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra A practical computer-based approach to the analysis of radioligand binding experiments Citalopram — Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity 3Hmazindol binding associated with neuronal dopamine and norepinephrine uptake sites Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice. Quantitative receptor autoradiography using [3H]ultrofilm: application to multiple benzodiazepine receptors. Neurotoxicity of the meperidine analogue N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on brain catecholamine neurons in the mouse Effect of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) on monoamine neurotransmitters in mouse brain & heart Blockade of monoamine uptake by 1-amino-4-phenylbicyclo(2,2,2)octane (EXP 561) in rat brain and heart Barbiturate recognition site on the GABA/benzodiazepine receptor complex is distinct from the picrotoxinin/TBPS recognition site Reduction of dopamine uptake and cocaine binding in mouse striatum by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Neurochemical and behavioral effects of systematic and intranigral administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the rat Repeated administration of N-methyl-4-phenyl 1,2,5,6-tetrahydropyridine to rats is not toxic to striatal dopamine neurones. The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the monkey and man Brain enzyme is the target of drug toxin. Specificity of antisera prepared against pure bovine MAO-B. Characterization of [3H]desipramine binding associated with neuronal norepinephrine uptake sites in rat brain membranes. High-affinity binding sites for [3H]MPTP may correspond to monamine oxidase N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) affects locomotor activity without producing a nigrostriatal lesion in the rat Quantitative autoradiography of [3H]MPTP binding sites in rat brain
author name string	wds:Q37683630-277C2A10-8792-4227-9D65-D8112E6622C0 wds:Q37683630-B064F91E-9D49-4BC3-ABA5-918B3018F40F
author name string	J A Javitch R J D'Amato
rdfs:label	Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity (en) Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity (nl) Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity (ast)

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