About: Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas

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About: Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas Goto Sponge NotDistinct Permalink

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scientific article published on December 1999

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 1999 (ast) наукова стаття, опублікована в грудні 1999 (uk) مقالة علمية نشرت في ديسمبر 1999 (ar) scientific article published on December 1999 (en)
publication date	wds:Q37642623-3B9A5A39-EC64-401F-B840-9025363FBAAA
publication date	1999-12-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37642623-D81D3AD0-5759-4367-9A52-8391D35161DF
language of work or name	English
cites work	wds:Q37642623-00F3F60D-0798-4D2F-B434-84BA32E464E3 wds:Q37642623-1FBC06F9-EE29-40D5-B73B-967E6AC874C5 wds:Q37642623-2FE4D0CA-85D0-497A-809D-BDB787544D14 wds:Q37642623-30D82DFB-C54B-4FE6-99BF-D5E021CCF48F wds:Q37642623-36DDCFD7-2A33-4496-84E7-FF944239AA38 wds:Q37642623-399C11E9-0C29-4CBC-BD42-1E7FD478A3F0 wds:Q37642623-3EA35590-8280-4BBD-B7A1-51C0819C1D0D wds:Q37642623-5F58E06B-0FB8-4FAB-885C-3658D239E82B wds:Q37642623-5F9B4C6C-1120-425C-B805-584C802BE1F2 wds:Q37642623-63948355-E4DD-4CEA-B2BB-A60F31C5B6EA wds:Q37642623-67F2B176-4500-47CA-A1EB-9450A0CF4482 wds:Q37642623-6968BE1C-2B6C-41A1-AEC3-6FDCAEE6372A wds:Q37642623-72517332-5EE6-4E1E-A127-BA6A8D341C30 wds:Q37642623-7388D08C-6BC3-4E3D-9F5B-B149415FC733 wds:Q37642623-7B834A17-2FFB-416B-8FE5-E081FF364EF0 wds:Q37642623-8E394BDF-D9A5-476A-AA18-E734223B221B wds:Q37642623-9CDAF771-63F8-44AF-919E-8E1C1E8AD54B wds:Q37642623-A21A4922-3EDE-4F3B-83C7-B7602AB6BFA8 wds:Q37642623-A3CE752B-B625-42E6-880A-C5DB8A177EFF wds:Q37642623-AE2D19DA-E965-4F5D-AB98-C30EF1CBFD49 wds:Q37642623-B41AF16A-8929-4FF6-9199-1AE164B26098 wds:Q37642623-CE40984A-7A8A-466C-BDE1-B250DECE1FB0 wds:Q37642623-D0EAB7D0-5BD2-4752-900F-AA966E2BEF78 wds:Q37642623-D2F8E61D-55B0-4DE8-86C2-6571FDF1394B wds:Q37642623-D96CFA9F-1F04-4CD9-B336-4B2018B80ED2 wds:Q37642623-DBB91A73-D6B9-40B0-9CE0-4A3E1508593A wds:Q37642623-E41D1906-DB7D-424C-9902-E5C699D7E232 wds:Q37642623-E4376400-EF28-47C3-95E2-10782767D8AD wds:Q37642623-E53E9F11-5999-42A3-B713-66DF05D80925 wds:Q37642623-EDA99141-427F-452B-9E7A-F3641360306C wds:Q37642623-F18C2519-DEBE-4ED9-82CD-C746D2FC531A wds:Q37642623-F2AED95F-1FE8-47B9-8E24-1DE7BC0815F5
cites work	The lipid phosphatase activity of PTEN is critical for its tumor supressor function The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer PTEN1 is frequently mutated in primary endometrial carcinomas PTEN gene mutations are seen in high-grade but not in low-grade gliomas. Somatic mutations of PTEN in glioblastoma multiforme. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome PTEN/MMAC1 mutations and EGFR amplification in glioblastomas. The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers. Distinct regions of allelic imbalance on chromosome 10q22-q26 in squamous cell carcinomas of the lung. PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues PTEN/MMAC1 mutations in endometrial cancers. Estimates of the worldwide frequency of sixteen major cancers in 1980 Prevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: a prospective clinico-pathological study and survival analysis of 70 patients. Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. Analysis of PTEN and the 10q23 region in primary prostate carcinomas Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q. Presence of human papillomavirus in esophageal squamous cell carcinomas of Hong Kong Chinese and its relationship with p53 gene mutation Lack of somatic mutation in the PTEN gene in squamous cell carcinomas of human skin. Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas
author name string	wds:Q37642623-33E97FBF-2469-476A-AF6F-8BB085007BF0 wds:Q37642623-6890A4BE-D069-4B06-8DE8-56B7D1EBDAF5 wds:Q37642623-8D6D8E3A-3713-4413-BB4A-9189F350855D wds:Q37642623-DA0652A7-1E4B-4B37-9D75-68D072649FD5
author name string	G Srivastava Y C Hu J C Tang K Y Lam
rdfs:label	Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas (en) Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas (nl) Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas (ast)
skos:prefLabel	Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas (en) Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas (nl) Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas (ast)
name	Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas (en)

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