About: Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

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About: Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells Goto Sponge NotDistinct Permalink

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scientific article published on April 1996

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 1996 (ast) 1996年學術文章 (zh) наукова стаття, опублікована у квітні 1996 (uk) مقالة علمية نشرت في أبريل 1996 (ar) scientific article published on April 1996 (en)
publication date	wds:Q37640365-F4041EEF-C444-40A3-8D11-FA941B2AC77F
publication date	1996-04-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37640365-62578533-AE26-4CF3-A987-315EC858014F
language of work or name	English
cites work	wds:Q37640365-01ED8EEE-212C-469D-9522-9E4AE9FD5D4E wds:Q37640365-02B8DBD6-BCCD-49B1-94C8-FB34AF42344D wds:Q37640365-07141F0C-0CA5-42EF-BD39-9DAE448C849A wds:Q37640365-07CC3EF1-A9E0-44DE-B409-F968501D1BC4 wds:Q37640365-09AAAFD8-1EE0-40D0-B346-75C241E81E2F wds:Q37640365-09EA3634-41F6-4849-B0B6-7C5900BBFD8D wds:Q37640365-2A43A736-669C-4F7D-A53A-EEEFB8BBE37F wds:Q37640365-32EF2B39-F8DC-44B1-A001-CCAF9FAE0E2D wds:Q37640365-35FFD976-36CB-45EE-80B4-4167D5AB33AE wds:Q37640365-44B1FED7-0AAF-455E-B273-622B2E96513E wds:Q37640365-4F8F6F83-6792-433E-B76E-F6C5B081E69D wds:Q37640365-55285352-839B-4065-B1A7-527C8276099B wds:Q37640365-5741D012-794F-4C9C-AE06-6C9BB39B100B wds:Q37640365-5CF4652D-0A7B-4B07-9A91-8C92A0414060 wds:Q37640365-695D8AB3-B684-495A-9EF3-0BCA17F8AEBC wds:Q37640365-742C5B19-6C18-4DCE-B6DC-FBE51E014906 wds:Q37640365-85BA2449-6B88-48A3-A51C-80C06667BD96 wds:Q37640365-93037BC2-F55B-4EB4-B0B3-56914AA1AEB7 wds:Q37640365-A314AF53-A3AB-449F-BA23-283CE8037BB1 wds:Q37640365-A58D2581-6B85-4E3D-9919-2F8253B93FF7 wds:Q37640365-A819DFEF-9E32-4462-92B4-32557C646D3C wds:Q37640365-D19B07D7-3E92-44AA-9677-6EB68EC64BD1 wds:Q37640365-DF89D694-0201-45E1-92A5-6419116F8626 wds:Q37640365-E2BAD268-ABF5-4E05-B61B-B6D495567BE4 wds:Q37640365-E8CEAC46-1ADB-4BAD-8297-B1E71A5C7EF6 wds:Q37640365-EC975066-8757-453C-A912-0363322F82A6
cites work	All ras proteins are polyisoprenylated but only some are palmitoylated Sequence dependence of protein isoprenylation Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 ras genes Protein lipidation in cell signaling Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes ras oncogenes in human cancer: a review Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells. Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells p21ras is modified by a farnesyl isoprenoid Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role cDNA cloning and expression of the peptide-binding β subunit of rat p21rasfarnesyltransferase, the counterpart of yeast DPR1/RAM1 CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins. Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro. A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme. Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase. Differential prenylation of proteins as a function of mevalonate concentration in CHO cells
author name string	wds:Q37640365-471DC962-15CA-4030-8B2C-5241789F3B4E wds:Q37640365-D0FC4080-7324-40F5-ACA8-DEBF9366812E
author name string	M S Brown G James
rdfs:label	Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells (en) Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells (nl) Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells (ast)
skos:prefLabel	Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells (en) Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells (nl) Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells (ast)
name	Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells (en) Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells (nl) Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells (ast)
author	wds:Q37640365-965E20D1-63BA-4FB8-88D1-FBA3D31BF3AA
author	Joseph L. Goldstein
title	wds:Q37640365-DD481079-3A6F-4AF2-8571-1502B36F6E3A
title	Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells (en)
page(s)	wds:Q37640365-03BD96F6-8492-4C2C-A231-142176EFC5AA
page(s)	4454-4458
instance of	wds:Q37640365-6E0F52DD-0055-4410-AFD6-56EB577C36A9
instance of	scholarly article
PubMed ID	wds:Q37640365-CA6E2324-1956-4951-B5A9-2F765E17F396
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8633088
PubMed ID	8633088
published in	wds:Q37640365-E969B094-F2EE-49F8-AB9D-63E60053A777
published in	Proceedings of the National Academy of Sciences of the United States of America

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