About: EZH2 expands breast stem cells through activation of NOTCH1 signaling

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About: EZH2 expands breast stem cells through activation of NOTCH1 signaling Goto Sponge NotDistinct Permalink

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scientific article published on 10 February 2014

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description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) 2014年學術文章 (zh) artículu científicu espublizáu en 2014 (ast) наукова стаття, опублікована в лютому 2014 (uk) scientific article published on 10 February 2014 (en) 2014 թվականի փետրվարի 10-ին հրատարակված գիտական հոդված (hy) مقالة علمية نشرت في 10 فبراير 2014 (ar)
publication date	wds:Q37612687-2D3EB37D-C382-4C6D-891D-A625AB30DA39
publication date	2014-02-10 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37612687-1FCEDA75-9D47-4627-A6A9-019A3439BCCE
language of work or name	English
cites work	wds:Q37612687-0ECF67F7-CFA7-4B75-B461-79D4609F08D3 wds:Q37612687-14BC4BF5-68C0-480D-BE9C-34282A5CB672 wds:Q37612687-1DC8A455-A4C8-41F3-9D31-04BED5502455 wds:Q37612687-2089E9E9-C656-4AA8-A9C9-38838F3EED88 wds:Q37612687-2D552817-C7E5-4829-87AB-E358E125EE5F wds:Q37612687-3EE90C9B-0F3F-4102-984F-B1F6C261D6E3 wds:Q37612687-49BCBD92-E4FC-432A-AD32-AF84230AB08C wds:Q37612687-51EE5936-4098-42D5-9651-1D798BFEA40C wds:Q37612687-53ED9DEA-B379-44EF-8EDE-39F277D75CDA wds:Q37612687-594F8716-BEB3-436C-B05C-973132B635A4 wds:Q37612687-66914A87-D75C-467F-8922-F0AF4D418A20 wds:Q37612687-6CCB6784-0641-4D59-A0B6-95B5EA388B92 wds:Q37612687-6FF1B651-1C12-4054-A96E-D9E93C307ECB wds:Q37612687-7097703D-9F9C-400B-82DD-6B5E73C361E9 wds:Q37612687-7176CC4D-B448-45E2-A826-EF9876B8C72A wds:Q37612687-83809A9E-878A-4848-B39A-69ACC7BCEB35 wds:Q37612687-83851B31-E9A4-4FB8-9CEA-C811BC3DFB09 wds:Q37612687-8AAAA5B6-6F6D-4315-BED6-DEA13105BD72 wds:Q37612687-8ABEF300-D3E5-4F04-919F-DF0170039DE6 wds:Q37612687-91E35143-B6E7-49E1-AB24-E3E4A238BFBC wds:Q37612687-94DDDA2D-965E-4E1D-A21D-5456D8AA23F8 wds:Q37612687-98A0E017-884E-4248-AFBD-C0CE5751E74B wds:Q37612687-BAEAC72A-2365-4581-B4F2-18B7C63F8C45 wds:Q37612687-BE747225-6113-47AE-AD18-2BC6BE9395B7 wds:Q37612687-CF1F59BC-4508-44AB-8237-87A0C29DB2A7 wds:Q37612687-D0BB8C3F-223E-4E39-BDB9-75CE64FFC8A6 wds:Q37612687-D51ABFEA-F8FE-4235-A2BF-AA23D6A83672 wds:Q37612687-D6963923-B559-46C7-94EB-0962062765B6 wds:Q37612687-DAE43125-D8F3-45CA-93FE-A27B379600A8 wds:Q37612687-E7CD422C-CDB6-4E70-A146-9219C22364B5 wds:Q37612687-ED409A45-A723-4C48-B607-1DB292FB3ADE wds:Q37612687-FC3CD205-F644-4D20-89C4-546066B01033
cites work	Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome. An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia Role of histone H3 lysine 27 methylation in Polycomb-group silencing NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications. Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent Context-specific regulation of NF-κB target gene expression by EZH2 in breast cancers. Prospective identification of tumorigenic breast cancer cells Slug and Sox9 cooperatively determine the mammary stem cell state Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors Mechanisms of transcriptional memory The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus Notch1 expression in early lymphopoiesis influences B versus T lineage determination. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1 Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells Repression of E-cadherin by the polycomb group protein EZH2 in cancer The role of EZH2 in tumour progression EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling. Identification of EZH2 as a molecular marker for a precancerous state in morphologically normal breast tissues Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. H3K4 methyltransferase Set1 is involved in maintenance of ergosterol homeostasis and resistance to Brefeldin A.
author name string	wds:Q37612687-1FD2DEFC-C19B-4789-A187-B190EC27E52F wds:Q37612687-32EE603E-CBD9-46A0-9BD0-65FDA487CE85 wds:Q37612687-3A329FDC-0FF0-47F6-8980-292981758E39 wds:Q37612687-5595A1BE-8459-4903-895C-2EF259368385 wds:Q37612687-5DFE2BBE-59D3-4679-8C55-298DFF1B84C3 wds:Q37612687-C4AFC490-9A58-4347-AB8B-B5409D740DE0 wds:Q37612687-DAEAB8B8-EC22-443E-A53D-98914806A037
author name string	Celina G Kleer Michael S Sabel Xin Li Wei Huang Kathy A Toy Heather M Moore

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