About: IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans.

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About: IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans. Goto Sponge NotDistinct Permalink

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scientific article published on 14 June 2016

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2016 (ast) наукова стаття, опублікована в червні 2016 (uk) مقالة علمية نشرت في 14 يونيو 2016 (ar) scientific article published on 14 June 2016 (en)
publication date	wds:Q37457451-0374B42C-B90B-4FBF-9669-A6F3241A4EF2
publication date	2016-06-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37457451-0C9CD235-5EB5-451A-8785-91AA55818CC9
language of work or name	English
cites work	wds:Q37457451-0576C928-577D-4062-B94F-EA9777691498 wds:Q37457451-08590D78-E134-4B23-8926-761D128AE7EF wds:Q37457451-0FCA3D69-1385-4BE5-B237-A1548828A57B wds:Q37457451-191311B0-1608-4946-B6DB-80E52A5AE6EE wds:Q37457451-1E214955-FD3C-4FDC-95FB-70355BB9CFB4 wds:Q37457451-1E619DED-76E7-4D60-A81F-EA6DDE44EACA wds:Q37457451-24EC3A5D-5B91-40B5-BCA9-2DC3A2E903FE wds:Q37457451-39DCABFA-A60B-4767-805E-6829C2A21373 wds:Q37457451-5A48135C-166B-46D1-A2A1-FB8CDEC53122 wds:Q37457451-5F544724-1D59-4B50-9AB9-307BED72869C wds:Q37457451-6443E8F8-01A0-4577-876B-A01E38F87543 wds:Q37457451-7126FE0F-007D-4B98-AD0F-F9F03F0AD97F wds:Q37457451-732AA3CA-C349-45A0-A309-E595F4993FCC wds:Q37457451-7AB0EA4A-4800-4D32-B44B-65442BC9CAD5 wds:Q37457451-89DAA5C2-596B-4BB9-928F-AD11C63D3CCF wds:Q37457451-8A97B899-D1EB-4E64-92D1-95CDA884FBFD wds:Q37457451-8E581918-4477-4265-BA52-DEEE05F86024 wds:Q37457451-8F7C22E7-C475-4073-8061-33B951E8E177 wds:Q37457451-921CA339-98A7-4418-BEF7-C5375E319FD8 wds:Q37457451-99D32E82-3496-4E24-91CC-114EA47BF387 wds:Q37457451-9B42ECC5-8E8C-46B9-9AE6-E46668F8A209 wds:Q37457451-B967275C-7D4E-4D5B-9453-4898E6A63AB9 wds:Q37457451-C52DC8AB-3D2D-4F77-9EF3-34797C66D6DE wds:Q37457451-D2BD6653-CA57-4368-A4CA-F8858FC9C966 wds:Q37457451-D5092BE1-1F43-4E6D-8E02-AF96D8FF23CA wds:Q37457451-E954A6AF-F3CE-4B4F-963C-234F2142C57B wds:Q37457451-EA58CD74-1653-4DF6-B29E-16C1BE1890B4 wds:Q37457451-EC3640D3-B5E4-4209-9D6D-E9C861291B1B wds:Q37457451-FA0ED3B4-8861-4E9A-8CFB-9B02CF6E2BFB
cites work	T cell responses are better correlates of vaccine protection in the elderly Mortality associated with influenza and respiratory syncytial virus in the United States Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism Influenza-associated hospitalizations in the United States Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo. Impact of post-thymic cellular longevity on the development of age-associated CD4+ T cell defects Immunity and ageing in man. Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals Impact of respiratory virus infections on persons with chronic underlying conditions GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults Clinical and immunologic predictors of influenza illness among vaccinated older adults The effects of IL-6 on CD4 T cell responses Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: higher antibody and lower cell-mediated immune responses with advanced age. Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans CD4 T cell defects in the aged: causes, consequences and strategies to circumvent T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo Priming CD8+ T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8+ T cells retaining CD28. The defects in effector generation associated with aging can be reversed by addition of IL-2 but not other related gamma(c)-receptor binding cytokines. Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo Non-regulatory CD8+CD45RO+CD25+ T-lymphocytes may compensate for the loss of antigen-inexperienced CD8+CD45RA+ T-cells in old age Presentation without proteolytic cleavage of endogenous precursors in the MHC class I antigen processing pathway
author name string	wds:Q37457451-56C33B3D-E2F8-4400-8533-4CCAA6D80432 wds:Q37457451-5A33A02C-A678-40B4-99CD-880B9AEE26EB wds:Q37457451-6B08F72C-C4FB-4128-A7BF-F565481375B8 wds:Q37457451-A7205E03-0CFD-4912-AC68-FB8219C273BD wds:Q37457451-E8A20378-6B0B-4FAB-85B1-7639C1CD873E
author name string	Xin Zhou Laura Haynes Jacob W Hopkins Chongkai Wang Vinayak Brahmakshatriya
rdfs:label	IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans. (en) IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans. (nl) IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans. (ast)
skos:prefLabel	IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans. (en) IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans. (nl) IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans. (ast)
name	IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans. (en) IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans. (nl) IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans. (ast)
author	wds:Q37457451-797B2C3D-042A-4A4C-9B13-01E3BF19188C wds:Q37457451-7C12A496-AEE7-4049-A36B-549EAFE2D9D6

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