About: Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents

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About: Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents Goto Sponge NotDistinct Permalink

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scientific article published on 13 October 2009

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2009 (ast) наукова стаття, опублікована в жовтні 2009 (uk) scientific article published on 13 October 2009 (en) مقالة علمية نشرت في 13 أكتوبر 2009 (ar)
publication date	wds:Q37441387-8955CF77-2EBB-4516-9CA9-7CCCE6364F3F
publication date	2009-10-13 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37441387-D119C76F-CC12-4221-9AEF-04A3101C47DE
language of work or name	English
cites work	wds:Q37441387-4476298A-0795-4BFD-A944-5811B17450C2 wds:Q37441387-6D88B5A3-2DD4-4289-B89D-AFD6CC2668DD wds:Q37441387-DA834C4D-678F-45C2-92CD-85D3AA21458A wds:Q37441387-FF24FE5A-5667-4183-A0AD-D94416AF83C2
cites work	Rational modification of a candidate cancer drug for use against Chagas disease The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase Cure of short- and long-term experimental Chagas' disease using D0870
rdfs:label	Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents (en) Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents (nl) Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents (ast)
skos:prefLabel	Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents (en) Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents (nl) Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents (ast)
name	Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents (en) Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents (nl) Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents (ast)
author	wds:Q37441387-402302D2-CD56-40A2-9CA0-1DC914FD9D24 wds:Q37441387-497E3E54-C5DE-4347-9EBB-5091C1EDB5FA wds:Q37441387-B452950A-2147-4CA0-881D-D37A1226EDD6 wds:Q37441387-FD99E536-A0D3-41D8-9EAA-339514E1A921
author	Michael H. Gelb Frederick S Buckner Naveen Kumar Chennamaneni Jenifer Arif
title	wds:Q37441387-F623644B-875D-4F26-8F29-B991526CC5BE
title	Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents (en)
page(s)	wds:Q37441387-8FFE2D77-33B9-4D6D-A16D-2CA2948437F3
page(s)	6582-6584
instance of	wds:Q37441387-87039F0B-693E-40AD-A536-454E14072673
instance of	scholarly article
main subject	wds:Q37441387-635C16E4-5BAE-4D80-924C-2F8E32DE65FE
main subject	Trypanosoma cruzi
PubMed ID	wds:Q37441387-FAFC2C1F-38D8-44C8-94E5-B8D0ED78FE6F
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19875282
PubMed ID	19875282
published in	wds:Q37441387-3D24430F-B137-4696-BD2C-2E6739417EF5
published in	Bioorganic & Medicinal Chemistry Letters
issue	wds:Q37441387-35A6E5AE-5A41-4A27-ABEE-072025245829
volume	wds:Q37441387-64911EA0-C9A8-4124-BBA2-4731314B0C53
issue	23
volume	19
DOI	wds:Q37441387-7EEB185F-CF14-43E2-935E-45DCE78C2501
DOI	http://dx.doi.org/10.1016/J.BMCL.2009.10.029
DOI	10.1016/J.BMCL.2009.10.029
ResearchGate publication ID	wds:Q37441387-5A969253-5AC7-46B2-A4BA-4F9E5D32F765
ResearchGate publication ID	38053762
PMCID	wds:Q37441387-F0F94077-7F69-478D-86AF-20BCD1354EA8
PMCID	2783978
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q37441387
is cites work of	Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51 Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target Drug strategies targeting CYP51 in neglected tropical diseases Synthetic Medicinal Chemistry in Chagas' Disease: Compounds at The Final Stage of "Hit-To-Lead" Phase N-Substituted Auxiliaries for Aerobic Dehydrogenation of Tetrahydro-isoquinoline: A Theory-Guided Photo-Catalytic Design Trypanocidal activity of marine natural products 4-Aminopyridyl-Based CYP51 Inhibitors as Anti- Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51. Advances in the Preparation of Fluorinated Isoquinolines: A Decade of Progress
is cites work of	wds:Q38974228-E89AF9C1-9B86-4441-A747-EB9ED0D7E59D wds:Q92377531-1E4F72F2-46C0-4364-A45D-BE8989C14F84 wds:Q27008593-CA256E8F-B1A0-46EF-82FE-456E00BC6877 wds:Q28481694-FB173817-327D-4F6D-AC20-4F9B0C40C398 wds:Q36594213-A816BCB2-FE89-4929-A370-754F1F56B361 wds:Q27684956-0AFF6119-EE93-4D60-9BB3-47E8588F99A1 wds:Q59145785-ABBBA21E-106F-4C55-A26C-130A9981A864 wds:Q27660510-83E7DAE5-CA05-46F3-B325-37C880EA2490 wds:Q34622554-3A508B64-3A1E-4D0A-AE91-1B054BFBF7F1 wds:Q34701325-27C3949C-F8AA-432E-B9E8-C9688361CED4

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