About: A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn

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About: A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn Goto Sponge NotDistinct Permalink

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scientific article published on January 2009

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2009 (ast) наукова стаття, опублікована в січні 2009 (uk) مقالة علمية نشرت في يناير 2009 (ar) scientific article published on January 2009 (en)
publication date	wds:Q37404434-E86589DE-B178-4868-BFCB-223D295C381A
publication date	2009-01-01 00:00:00Z (xsd:dateTime)
author name string	wds:Q37404434-3D7605D2-3246-4878-9BB1-59DA9BD99EC2 wds:Q37404434-6D95FB57-F5FC-4A27-BC3A-F8353148EC04 wds:Q37404434-A0801562-F936-4808-B6CC-9784684D5A7A
author name string	Masoud Jamei Amin Rostami-Hodjegan Gemma L Dickinson
rdfs:label	A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn (en) A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn (nl) A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn (ast)
skos:prefLabel	A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn (en) A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn (nl) A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn (ast)
name	A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn (en) A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn (nl) A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn (ast)
title	wds:Q37404434-A0621E3C-4273-4D01-ADFD-C6C013265442
title	A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn (en)
page(s)	wds:Q37404434-ED90E848-BCD6-4C5C-9663-8DC7E52AEE6D
page(s)	53-75
instance of	wds:Q37404434-56433B8C-F3F9-4C53-84EA-D2825D1CC630 wds:Q37404434-ca276441-b872-49ae-a22e-0dd2cfee21e3
instance of	review article scholarly article
main subject	wds:Q37404434-044DF1FF-3063-419B-A2AF-0C979F4E6D6B wds:Q37404434-36C717C8-F1D2-48E3-AE94-040FE7939702 wds:Q37404434-3DF83348-31CD-4B91-8B99-F346AC1574EB
main subject	pharmacokinetics physiology human population genetics
PubMed ID	wds:Q37404434-DC6B18A8-7450-4D23-AEE4-9957764D1199
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19252336
PubMed ID	19252336
published in	wds:Q37404434-24AB2F7D-2DED-4020-9F13-8ECBB22570DE
published in	Drug Metabolism and Pharmacokinetics
issue	wds:Q37404434-91016AFF-4C39-40AF-930F-3A89A9298962
volume	wds:Q37404434-2B661F03-7628-4540-B9C6-2C1B7E8F8450
issue	1
volume	24
DOI	wds:Q37404434-BCBECDE4-7BA2-473F-899E-447F014A7F96
DOI	http://dx.doi.org/10.2133/DMPK.24.53
DOI	10.2133/DMPK.24.53
ResearchGate publication ID	wds:Q37404434-03B79647-D5B5-4B9C-9F59-05F997879BFC
ResearchGate publication ID	24146872
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q37404434
is cites work of	The in silico child: using simulation to guide pediatric drug development and manage pediatric pharmacotherapy. Physiologically based pharmacokinetic (PBPK) modeling in children Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations Modeling and predicting drug pharmacokinetics in patients with renal impairment. Evaluation of exposure change of nonrenally eliminated drugs in patients with chronic kidney disease using physiologically based pharmacokinetic modeling and simulation. The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine FutureTox: building the road for 21st century toxicology and risk assessment practices Anatomical, physiological and metabolic changes with gestational age during normal pregnancy: a database for parameters required in physiologically based pharmacokinetic modelling. Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010. A neonatal amikacin covariate model can be used to predict ontogeny of other drugs eliminated through glomerular filtration in neonates Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review In vitro-in vivo extrapolation of zolpidem as a perpetrator of metabolic interactions involving CYP3A. Dose selection based on physiologically based pharmacokinetic (PBPK) approaches Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development Predicted metabolic drug clearance with increasing adult age. Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical Models Combining the 'bottom up' and 'top down' approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug-Drug Interactions. Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System Differences in cytochrome p450-mediated pharmacokinetics between chinese and caucasian populations predicted by mechanistic physiologically based pharmacokinetic modelling Pharmacokinetics, pharmacodynamics and physiologically-based pharmacokinetic modelling of monoclonal antibodies A semi-mechanistic model to predict the effects of liver cirrhosis on drug clearance Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19 A PBPK Model to Predict Disposition of CYP3A-Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women The role of physiologically based pharmacokinetic modeling in regulatory review CYP2B6 pharmacogenetics-based in vitro-in vivo extrapolation of efavirenz clearance by physiologically based pharmacokinetic modeling Population-based mechanistic prediction of oral drug absorption Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification Prediction of drug disposition in diabetic patients by means of a physiologically based pharmacokinetic model What is the right dose for children? Potential Sources of Inter-Subject Variability in Monoclonal Antibody Pharmacokinetics Tips and traps analyzing pediatric PK data. Utility of a physiologically-based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug-drug-disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice. Physiologically based pharmacokinetics joined with in vitro-in vivo extrapolation of ADME: a marriage under the arch of systems pharmacology

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