About: Complement and microglia mediate early synapse loss in Alzheimer mouse models.

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About: Complement and microglia mediate early synapse loss in Alzheimer mouse models. Goto Sponge NotDistinct Permalink

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scientific article published on 31 March 2016

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2016 (ast) наукова стаття, опублікована в березні 2016 (uk) scientific article published on 31 March 2016 (en) مقالة علمية نشرت في 31 مارس 2016 (ar)
publication date	wds:Q37391481-2501BCCC-44D4-43DA-BA17-C9F30BDEF271
publication date	2016-03-31 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37391481-3BB61A31-D682-4E6D-93DC-FDBB94629DAE
language of work or name	English
cites work	wds:Q37391481-055C02C2-497B-48F0-BDBC-BD03E22E942A wds:Q37391481-08ACB99A-93E9-4768-9C2F-BA69BD5DAC06 wds:Q37391481-16B65180-39AE-4318-AC0B-7950AA8803F9 wds:Q37391481-26A9A8B4-D110-49CC-A4B9-707210B55BC1 wds:Q37391481-28B03F06-358D-4233-A16E-5EC387E024C2 wds:Q37391481-30752EE2-4280-4154-9315-2899E5731DB3 wds:Q37391481-341AFFD2-A50A-4306-A786-205DA6C6D380 wds:Q37391481-34F1D9D5-BA42-49C7-B1D0-F3BC2691864D wds:Q37391481-3986AEEA-CF53-47DD-AC0E-8C96834370B8 wds:Q37391481-4EC27609-BF15-413C-A175-1635DA2536CF wds:Q37391481-64B920D4-6C97-491A-AF43-7F77DDC4E332 wds:Q37391481-66796C5B-8F37-47B9-8349-DB3A1A5128C9 wds:Q37391481-6F87CA78-3A48-4065-8474-0521F731C1AA wds:Q37391481-7DCF92C7-0364-4BAB-BC1A-CCF6AAB2B48C wds:Q37391481-85E2562E-0EEC-4343-8EE1-DD214E27A522 wds:Q37391481-8E264485-8A3E-4FEB-81BF-0F69CA24B5C7 wds:Q37391481-A0E3161F-C1CE-4B30-B516-9D11D7665B67 wds:Q37391481-AF9F9B6B-3674-4461-9180-68E6308E2CB5 wds:Q37391481-B19D4A69-77DC-4FC2-944B-82235E4760D1 wds:Q37391481-B8245292-158E-45B7-9A9E-281F06E9E2A6 wds:Q37391481-B84DE32A-A37B-41E6-87AC-C5B3A6D0637E wds:Q37391481-BED17FA9-7D3E-40DE-B190-734AECBB141A wds:Q37391481-C2D5549E-19B3-4E94-881F-9D0976C9EADB wds:Q37391481-CB508A98-E86F-4391-A736-B9B768592A60 wds:Q37391481-D3618D01-1FEB-4A8F-BA26-21AA55F2757D wds:Q37391481-DC7E97D1-0A80-4B93-BCDD-8B81BCF75BDE wds:Q37391481-DC95EFC2-20E4-4D9E-9205-7EC44301DA1A wds:Q37391481-E53CFA44-4FC4-4CE0-A2C8-A6EA2FE99193 wds:Q37391481-F5C432D5-DCCF-49C3-882F-71E41E161C01
cites work	Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment Alzheimer's disease is a synaptic failure High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment. Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner Neurotoxicity of amyloid β-protein: synaptic and network dysfunction Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. The classical complement cascade mediates CNS synapse elimination A dramatic increase of C1q protein in the CNS during normal aging. C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature The complement system: an unexpected role in synaptic pruning during development and disease TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement New insights on the role of microglia in synaptic pruning in health and disease Synchronized formation and remodeling of postsynaptic densities: long-term visualization of hippocampal neurons expressing postsynaptic density proteins tagged with green fluorescent protein. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase Identification of a unique TGF-β-dependent molecular and functional signature in microglia A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies Classical MHCI molecules regulate retinogeniculate refinement and limit ocular dominance plasticity Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity Aβ oligomers inhibit synapse remodelling necessary for memory consolidation An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons Structured Illumination Microscopy for the Investigation of Synaptic Structure and Function.
author name string	wds:Q37391481-01A9102A-AFFC-4BDA-AAE9-38D379E5A454 wds:Q37391481-17DAF813-4F1D-4350-B223-2618282F9F88 wds:Q37391481-420A6292-66CC-4FF4-A946-C1BB4F9A4229 wds:Q37391481-69B62638-E382-48B0-A530-523DCAD0F709 wds:Q37391481-8FF1DE5D-27D1-4591-989C-6DFF3100ECAA wds:Q37391481-ADAF6B70-FF02-4710-950D-48195FB565BA wds:Q37391481-AF5EFB02-F919-4C36-9FD9-C5CF0B915B53 wds:Q37391481-FA0B97D9-CC9B-47C9-BC78-DA7B6AF97416 wds:Q37391481-FA8D46FB-BDC7-4FEE-8425-BE8074317951 wds:Q37391481-FCB1D973-5DB0-4CEA-AB26-E47258E9142A
author name string	Arnon Rosenthal Shaomin Li Cynthia A Lemere Beth Stevens Soyon Hong Katherine M Merry Qiaoqiao Shi Arnaud Frouin Bianca M Nfonoyim Victoria F Beja-Glasser
rdfs:label	Complement and microglia mediate early synapse loss in Alzheimer mouse models. (en)

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