About: Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity.

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scientific article published on April 2009

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2009 (ast) наукова стаття, опублікована у квітні 2009 (uk) مقالة علمية نشرت في أبريل 2009 (ar) scientific article published on April 2009 (en)
publication date	wds:Q37254788-0ECBAFDD-6FA0-418D-AD59-0565CC7885C3
publication date	2009-04-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37254788-B390D2C3-3581-4315-9D19-DE2B57643C2B
language of work or name	English
cites work	wds:Q37254788-105DBBDA-5547-4E41-BB69-7AE79919FE44 wds:Q37254788-14804B67-1BD6-4A18-9FED-134514C4F9DF wds:Q37254788-23B3A624-3227-4E5F-87EC-852EB229A9FF wds:Q37254788-346C6137-D463-43B0-8E6C-C280BE866501 wds:Q37254788-3F59192E-E777-4E33-BD11-4F399EDE7D49 wds:Q37254788-41C8BAA9-2FF3-43AB-A089-574E9C792349 wds:Q37254788-66A951B9-EF61-45C7-906C-154DFB45BB62 wds:Q37254788-708B3195-50AE-49D1-BC4F-726B81B0351D wds:Q37254788-784DA946-7E09-4612-AECB-1C7B13605043 wds:Q37254788-B90CA7EC-2BFE-4572-842A-401A72AA225B wds:Q37254788-CB75D2F7-3525-483E-AE36-5A9998C7A028 wds:Q37254788-CF7D22E0-029D-4CB5-BF30-01860358F714 wds:Q37254788-EC5CD280-8859-4EF9-89C7-25571B82BC39
cites work	Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure-based Drug Design of Serine/Threonine Phosphatase Inhibitors Regulators of serine/threonine protein phosphatases at the dawn of a clinical era? A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A. A new antibiotic, tautomycin Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1. Different moieties of tautomycin involved in protein phosphatase inhibition and induction of apoptosis. The structure of tautomycetin, a dialkylmaleic anhydride antibiotic Synthesis of specific protein phosphatase inhibitors, tautomycin and tautomycetin toward structure-activity relationship study A new model of the tautomycin-PP1 complex that is not analogous to the corresponding okadaic acid structure Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis The selective inhibition of phosphatases by natural toxins: the anhydride domain of tautomycin is not a primary factor in controlling PP1/PP2A selectivity Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis
author name string	wds:Q37254788-02789E7F-35F8-4BB2-96B0-8762451A0BBE wds:Q37254788-34C0E05D-5F90-484A-B915-6396AE97B7F9 wds:Q37254788-4952FAD4-DF36-462F-99E5-38854A8C6331 wds:Q37254788-7B4C7DA0-51EF-48D5-8C52-7E42C94467A1 wds:Q37254788-7BB303EF-C8E3-451F-BF45-F86074002718 wds:Q37254788-DD4F5DD9-66E9-4CA1-B715-4F8868C853A5 wds:Q37254788-E48559AA-3020-4C2F-90F5-0357A2B6DD97
author name string	Ben Shen Hiroyuki Osada Qiuping Yuan Scott R Rajski Wenli Li Jianhua Ju Noel R Peters
rdfs:label	Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. (en) Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. (nl) Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. (ast)
skos:prefLabel	Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. (en) Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. (nl) Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. (ast)
name	Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. (en) Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. (nl) Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. (ast)
author	wds:Q37254788-675CA9C8-237A-470D-A8A2-27B70CC94B45
author	F M Hoffmann
title	wds:Q37254788-EBF26C6C-2A82-4ACF-B857-2471ECBB2CDC
title	Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity (en)
page(s)	wds:Q37254788-EADF8079-A26C-45D3-849A-5D0E7306F4A6
page(s)	1639-1642
instance of	wds:Q37254788-0E8AD0F2-9547-4418-A906-904DEFB071D4
instance of	scholarly article
PubMed ID	wds:Q37254788-E6DFCA5C-B11C-4C51-997B-ED44697439D2
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19281218
PubMed ID	19281218
published in	wds:Q37254788-AC999971-0A9A-4F33-9C77-71C2BD982F55
published in	Organic Letters
issue	wds:Q37254788-2EEE3212-07E0-4580-83FB-FADC97B4F551
volume	wds:Q37254788-874D31D9-6827-4761-B0BF-1BF0B1C95639
issue	7
volume	11
DOI	wds:Q37254788-AD4D59C1-4E83-4A6C-B060-186F7B023B92
DOI	http://dx.doi.org/10.1021/OL900293J
DOI	10.1021/OL900293J
ResearchGate publication ID	wds:Q37254788-BF3FDA89-656B-43D6-85FD-F1699F195684
ResearchGate publication ID	24196125
PMCID	wds:Q37254788-823E8EC0-2EA5-45E5-AE48-3CF1525B246D
PMCID	2707755
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q37254788
is cites work of	Metabolic engineering for the production of natural products. Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins SHP2 is a target of the immunosuppressant tautomycetin Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.

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