About: A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer

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About: A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer Goto Sponge NotDistinct Permalink

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scientific article published on 28 July 2002

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) bài báo khoa học (vi) article scientifique (fr) artículu científicu espublizáu en 2002 (ast) наукова стаття, опублікована в липні 2002 (uk) scientific article published on 28 July 2002 (en) مقالة علمية نشرت في 28 يوليو 2002 (ar)
publication date	wds:Q37218535-18ADFFAF-39F4-47A3-AEC3-EA046B976280
publication date	2002-07-28 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37218535-993155C9-0624-49E5-AB0E-5BE5EBBA5BD3
language of work or name	English
cites work	wds:Q37218535-1D9F8E09-F9C5-4727-BB17-1A9EEA1B5C17 wds:Q37218535-204CDFB0-A640-4050-9257-C66DEB3093F3 wds:Q37218535-27658061-B3C4-4B07-AC34-45BC1AFDCF34 wds:Q37218535-27691CD7-6E3D-4C9F-8DA1-B0910AFDE1B7 wds:Q37218535-2CF2EE54-E486-499B-AABC-C3A8F7B0AECE wds:Q37218535-2D6C0238-FF78-4E4B-AD89-1B39589361DE wds:Q37218535-36B4109C-28D6-414E-9EB7-2DCCDFC157C3 wds:Q37218535-3DC1C4A5-5ECA-413D-A21C-3FE6599241B8 wds:Q37218535-3EBEA122-1469-43EB-B1FE-A9C0CA3D8F35 wds:Q37218535-40C4BBBF-4E36-499E-9399-B928783903AD wds:Q37218535-40E2072D-A457-4105-94BF-9F39BB7FC242 wds:Q37218535-419949C4-82BE-4AD5-8A68-761B9CFC9BD6 wds:Q37218535-41B0FBA9-A206-4E0A-AB48-827ACFCB8C47 wds:Q37218535-4FDF1501-F7CB-4012-98F3-3DB7D5E21959 wds:Q37218535-57669A33-EF39-4645-9E5B-610A3890F9B9 wds:Q37218535-59F0718C-AF26-4E0F-A080-A60AE00B32F8 wds:Q37218535-76CD0196-96DF-4AE0-8305-033131A7066B wds:Q37218535-9F8FB691-73CB-4DAC-BA2F-0052EFB20549 wds:Q37218535-A7EA4119-BCA1-449A-9AEF-202460899771 wds:Q37218535-AE93102D-8EE0-4887-9312-A384FA80769F wds:Q37218535-B7F4645E-DEEB-4ABA-AC28-C871C1DEC6E0 wds:Q37218535-C13DCD64-D93A-4642-A9F9-82DF83D87609 wds:Q37218535-C508DF92-F283-40B6-B369-44B3F44A2662 wds:Q37218535-C8721687-A53F-4CD2-AA71-6C09D5AE1A44 wds:Q37218535-CA4B1291-7E92-4000-856E-BDB66AE29EE5 wds:Q37218535-DB676073-2008-4FB9-8911-DDC717B74CBB wds:Q37218535-EA2C41B0-26DC-4CA9-AD43-914360FA5834 wds:Q37218535-F976F1C4-199B-4FCB-A3A4-730222866AB7
cites work	Linkage of ATM to cell cycle regulation by the Chk2 protein kinase Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro The many substrates and functions of ATM The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53 Familial breast cancer in southern Finland Low proportion of BRCA1 and BRCA2 mutations in Finnish breast cancer families: evidence for additional susceptibility genes The DNA damage response: putting checkpoints in perspective hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response A systematic review of genetic polymorphisms and breast cancer risk. Identification of individuals by analysis of biallelic DNA markers, using PCR and solid-phase minisequencing A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes CHK2 kinase--a busy messenger. Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations Evidence for further breast cancer susceptibility genes in addition to BRCA1 and BRCA2 in a population-based study p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: further evidence of CHK2 in inherited cancer predisposition Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias A probability model for predicting BRCA1 and BRCA2 mutations in breast and breast-ovarian cancer families Population-Based Study of BRCA1 and BRCA2 Mutations in 1035 Unselected Finnish Breast Cancer Patients Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome Characterization of tumor-associated Chk2 mutations Histological type-selective, tumor-predominant expression of a novel CHK1 isoform and infrequent in vivo somatic CHK2 mutation in small cell lung cancer Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. Analysis of the CHK2 gene in lymphoid malignancies Risk of cancer in BRCA1 and BRCA2 mutation-positive and -negative breast cancer families (Finland)
author name string	wds:Q37218535-05D04460-3648-4867-8E85-B7902683A72D wds:Q37218535-4A2232B8-F504-4F84-BFDE-090D68B913D2
author name string	Juha Kononen Salla Ojala
rdfs:label	A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer (en) A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer (nl) A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer (ast)
skos:prefLabel	A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer (en) A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer (nl) A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer (ast)
name	A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer (en) A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer (nl) A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer (ast)
author	wds:Q37218535-118768BF-7CD3-4A87-ADB0-8B645F988C9E wds:Q37218535-188A5C23-B91A-4C7D-BE8B-5CB14B75BC2D wds:Q37218535-1AAB3273-20C2-43F1-8E37-BCEE1F316104 wds:Q37218535-237F7643-DB01-4122-94BA-02D219D0A059 wds:Q37218535-2983CAA7-C83D-4209-865D-3EFB2C85DE23 wds:Q37218535-7E2923C4-2F8B-4276-BC19-6F9F1D228332 wds:Q37218535-8DB92B4F-2588-45FE-98E3-4CC58430F48E wds:Q37218535-B1EC996D-602E-44EB-9E95-CB44EB5372B7 wds:Q37218535-D3B564A5-F84E-4E19-BDC8-D54236A2FB1F

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