About: Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity.

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About: Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity. Goto Sponge NotDistinct Permalink

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scientific article published on 03 June 2013

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description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2013 (ast) наукова стаття, опублікована в червні 2013 (uk) scientific article published on 03 June 2013 (en) مقالة علمية نشرت في 03 يونيو 2013 (ar)
publication date	wds:Q37202320-F5C65CD9-744E-4352-A7C5-BC4DD6BAA20D
publication date	2013-06-03 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37202320-C97B9B83-4A6A-40B0-B0BA-B2EB207DF4E1
language of work or name	English
cites work	wds:Q37202320-0194C63D-FBB6-4F75-B813-121DF8E8DEC2 wds:Q37202320-12B8A583-C23C-434D-A319-1CFAAC73011D wds:Q37202320-1A31F0E8-88A3-4A9D-B359-9DF057FAC04D wds:Q37202320-1C97D2FB-1DEA-4B2B-9013-1ADCEC930766 wds:Q37202320-1F07334D-0092-4853-AE69-8E5297AF4776 wds:Q37202320-243A340B-789B-4297-837B-F9C9E1507F24 wds:Q37202320-3F485CA0-E713-4871-8340-AACDE8674AD7 wds:Q37202320-5C0254D5-15B9-4537-BCBC-A417E83BB108 wds:Q37202320-5D939B1D-F3A6-4F8A-B395-647007354BC5 wds:Q37202320-68A27486-CB91-46CA-9291-2C0A47E408D6 wds:Q37202320-7028634A-4F7E-4EE6-8CC8-89F6ED6C5693 wds:Q37202320-7AEF7FCA-6DDA-4D64-97AB-A967A120B66B wds:Q37202320-8131ED8F-EF6C-4EBA-BDE4-A1700AF3D29D wds:Q37202320-873B2161-D935-417F-8C13-51FDC87A6B9E wds:Q37202320-8CF96E82-1ECA-4AB0-AC1C-E346C9382F6B wds:Q37202320-9BA83A47-8CE7-4238-9AC1-3A7A80E82C1D wds:Q37202320-9E1C2CEF-1895-4480-AFE3-BD72931EC76C wds:Q37202320-9F4957FA-4CBE-40B9-A490-5EFABFFCE13F wds:Q37202320-A8267016-B429-4C8C-98DE-AA1710CC70D7 wds:Q37202320-A9C541C8-E29F-4F01-84E7-645D37707CE5 wds:Q37202320-A9EC6ED0-EEAF-40E4-B9EB-2A9878A4CF04 wds:Q37202320-AA2C8F28-5BF9-47A8-88BF-4D63DD9BB0DE wds:Q37202320-AB378AE7-47CF-4CC8-8C3C-804C05ECDBB4 wds:Q37202320-ACCB5BDD-6166-438E-85DF-A8F9099DA160 wds:Q37202320-BA37CAAD-E0FA-41CB-AE0F-B9C3D92D5391 wds:Q37202320-C1821A23-859C-4C08-9DB8-E9DDC09831C1 wds:Q37202320-C2965F6A-D5CA-4094-A013-52E2BE9ACAFF wds:Q37202320-C3261A88-3190-4EBE-91FB-E6336DF999A0 wds:Q37202320-CF053B26-21DC-4376-8102-F22C2F18F2B1 wds:Q37202320-D2AC760B-7179-4CD1-85B9-87C46C15AE29 wds:Q37202320-D4C155B2-8E89-4E3F-A158-0738A187B2A0 wds:Q37202320-DE58D5A8-109D-4F54-9DD3-E5D97E7E7C6C
cites work	Ham-2 corrects the class I antigen-processing defect in RMA-S cells Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Characterizing the N-terminal processing motif of MHC class I ligands The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. ER aminopeptidases generate a unique pool of peptides for MHC class I molecules. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides. ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming 26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism. In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules Investigating the genetic association between ERAP1 and spondyloarthritis Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis. Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis. Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum. Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance. Disulfide bond engineering to trap peptides in the MHC class I binding groove The Group II Chaperonin TRiC Protects Proteolytic Intermediates from Degradation in the MHC Class I Antigen Processing Pathway Endoplasmic reticulum aminopeptidase associated with antigen processing regulates quality of processed peptides presented by MHC class I molecules Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1 A functional variant in ERAP1 predisposes to multiple sclerosis Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo Natural Killer Cells Efficiently Reject Lymphoma Silenced for the Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing Genetic variation of antigen processing machinery components and association with cervical carcinoma The role of MHC class I molecules in the generation of endogenous peptide/MHC complexes.
author name string	wds:Q37202320-11A0EFCD-7EBF-40D4-9FE1-DB3BB7AD50B3 wds:Q37202320-575C5CA1-4148-4CB1-B6AB-B1E933DEFDB1 wds:Q37202320-6A9BF5B1-ADB1-4A00-89A2-8528F0DD301E
author name string	Christopher J Edwards Edward James Emma Reeves
rdfs:label	Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity. (en) Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity. (nl) Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity. (ast)
skos:prefLabel	Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity. (en) Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity. (nl) Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity. (ast)
name	Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity. (en) Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity. (nl) Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity. (ast)

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