About: An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

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About: An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer Goto Sponge NotDistinct Permalink

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scientific article published on August 2008

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2008 (ast) наукова стаття, опублікована в серпні 2008 (uk) مقالة علمية نشرت في أغسطس 2008 (ar) scientific article published on August 2008 (en)
publication date	wds:Q37187915-18A0C5C8-CCF9-439D-9583-8E1E73FA6010
publication date	2008-08-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37187915-B5AA4601-62E7-4CB0-86BD-83AFFF6CC436
language of work or name	English
cites work	wds:Q37187915-0870AD5C-D0EA-4DA6-8F91-9A2A21DB4A81 wds:Q37187915-2C35ED7E-02EF-44C4-905E-220B878156CE wds:Q37187915-2D58E0D3-88D6-45AB-BB01-4399BDAF84D5 wds:Q37187915-38B6C702-F354-40D7-9003-C216F045A87A wds:Q37187915-48416DFC-E0FA-4FD5-B569-FA8915A2D522 wds:Q37187915-4C68478D-76A9-4778-80FB-AC1F86B10DEE wds:Q37187915-4C87CBFD-B4B9-48A6-9F51-6CA3854E53FA wds:Q37187915-4E8B9BD7-D75B-4B41-BB37-20697172CE6B wds:Q37187915-4F81EFDC-98F7-430D-A168-91E8AF99417B wds:Q37187915-53AD23A9-FB27-43D6-AEB2-F01B36993F1D wds:Q37187915-6B944CAD-8D6C-4F5C-8C5B-57DFE879B0BF wds:Q37187915-6E07CEEA-0519-429D-8C4D-72B9387F3708 wds:Q37187915-6FCE2E68-6990-4E84-A131-B5540EBD3721 wds:Q37187915-7052F46E-003F-497A-B562-15DBC58E4ADE wds:Q37187915-79E2A6BE-388D-493F-A93D-2B1432E5001F wds:Q37187915-909F65CC-DCEE-453E-887A-7CA32DC1F1FF wds:Q37187915-96CF8181-C2D6-4B3B-B2F1-215349518B77 wds:Q37187915-A343E4C3-B5AB-45C8-8E49-D61A2ED43BBB wds:Q37187915-C147AB7F-C8DA-447D-A50B-25F87BE7F689 wds:Q37187915-C826839A-228F-42C3-91EC-0C8CAB9DDB8D wds:Q37187915-CC97082D-742F-460F-ACB4-4AB9DC7D416E wds:Q37187915-E1CE1360-2855-4F3B-9466-225546CFB670 wds:Q37187915-E25E4CEA-4CAB-479B-BC1A-CCAEC76D99DC wds:Q37187915-F21BDCBF-9691-4A43-8385-4C4C611FC5AE
cites work	Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma A transforming mutation in the pleckstrin homology domain of AKT1 in cancer PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer High frequency of mutations of the PIK3CA gene in human cancers Exploiting the PI3K/AKT pathway for cancer drug discovery PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer High-throughput oncogene mutation profiling in human cancer The use of MassARRAY technology for high throughput genotyping The consensus coding sequences of human breast and colorectal cancers Patterns of somatic mutation in human cancer genomes Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas Pharmacodynamic markers of perifosine efficacy The PIK3CA gene is mutated with high frequency in human breast cancers. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.
author name string	wds:Q37187915-045FA1F9-33E1-454B-8B79-91A05EE04D4E wds:Q37187915-07FBE900-6836-4621-A84E-A27F8C383FB6 wds:Q37187915-14E1D511-E456-4D23-8F83-0148FA0EB467 wds:Q37187915-378863CC-65D0-445F-91AC-09E324BD5C6C wds:Q37187915-523925AC-7AAA-437A-9A78-596A61DD02B6 wds:Q37187915-8B995A79-EF97-4B97-8A28-6ED1BD0CF741 wds:Q37187915-8E93BD92-989D-42CE-B97B-54B9B103B930 wds:Q37187915-9FF8F6B6-D473-49C6-B3F6-8B01D641307F wds:Q37187915-A80842F5-7FA0-43D6-9D34-CA95D627AD8D wds:Q37187915-A9543206-6EA3-415B-B67F-27ABF3EBC0F2 wds:Q37187915-B827BAC4-A959-4E66-A608-B11D0DA920FA wds:Q37187915-BF045C35-0AD6-49FB-BFF9-22F48042EACB wds:Q37187915-CBF3F8D8-5204-4E93-AAEC-ACC7AC2AF0E0 wds:Q37187915-F0669B63-B42A-43F5-9FEC-6DE57127A4D4
author name string	Aysegul Sahin Lajos Pusztai Michael Davies W Fraser Symmans Vicente Valero Mark Carey Richard M Neve Zhi Hu Yinghui Guan Wen-Lin Kuo Ana Lluch Hugo Horlings Katrien Berns Laura K Nolden
rdfs:label	An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. (nl) An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer (en) An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer (ast)

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