About: Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology

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scientific article published on February 2008

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) bài báo khoa học (vi) article scientifique (fr) наукова стаття, опублікована в лютому 2008 (uk) مقالة علمية نشرت في فبراير 2008 (ar) scientific article published on February 2008 (en) artículu científicu espublizáu en febreru de 2008 (ast)
publication date	wds:Q37089872-B9999B1E-78A9-4419-B5BE-E008B5AAA1B0
publication date	2008-02-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37089872-5E22EAEF-9C07-4C3C-8A5F-F42CA38079B2
language of work or name	English
cites work	wds:Q37089872-0A02AB17-116C-4C09-95A1-AEF26F2D017C wds:Q37089872-73EE7B4E-54DE-4E7D-9F85-27C3398740AC wds:Q37089872-78056E41-E684-46F1-9892-858B5F8E4AB3 wds:Q37089872-F2A73892-9AE7-476B-B571-91C5A14153FC
cites work	Dynemicin A, a novel antibiotic with the anthraquinone and 1,5-diyn-3-ene subunit A new macromolecular antitumor antibiotic, C-1027. II. Isolation and physico-chemical properties Esperamicins, a novel class of potent antitumor antibiotics. I. Physico-chemical data and partial structure. Dynemicins, new antibiotics with the 1,5-diyn-3-ene and anthraquinone subunit. I. Productin, isolation and physico-chemical properties
author name string	wds:Q37089872-1E49C9F3-A018-4099-AE31-286C06F2540B wds:Q37089872-6775C004-5957-4E5B-AAF0-B56D5B1B9094
author name string	Rong-guang Shao Yong-su Zhen
rdfs:label	Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology (en) Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology (nl)
skos:prefLabel	Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology (en) Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology (nl)
name	Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology (en) Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology (nl)
title	wds:Q37089872-1D052CB2-336E-4F0B-9355-413B25C9011A
title	Enediyne anticancer antibiotic lidamycin: chemistry, biology and pharmacology (en)
page(s)	wds:Q37089872-5587E530-00F6-4855-ACBC-BA9EE51AA124
page(s)	123-131
instance of	wds:Q37089872-2bb8e5e1-215b-4f95-99f3-78fb33803cca wds:Q37089872-CAE0577C-F916-4F6B-8563-C86EEEE7E52C
instance of	review article scholarly article
main subject	wds:Q37089872-93F5C795-FAC0-40A4-8C5F-243E0C04C300
main subject	pharmacology
PubMed ID	wds:Q37089872-8540FE26-EAF0-468A-8F27-48F8F3EB3349
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18288918
PubMed ID	18288918
published in	wds:Q37089872-F125C584-EC25-44CE-B035-C775078F768D
published in	Anti-Cancer Agents in Medicinal Chemistry
issue	wds:Q37089872-7167B13F-E436-41C6-8933-E73E26A3E65C
volume	wds:Q37089872-BB8A7A6C-ADCD-420D-A828-1BEA125BCD31
issue	2
volume	8
DOI	wds:Q37089872-6520A8CD-A55D-48F0-AAD8-943D8E78D9E8
DOI	http://dx.doi.org/10.2174/187152008783497055
DOI	10.2174/187152008783497055
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q37089872
is cites work of	Antitumor effects of an engineered and energized fusion protein consisting of an anti-CD20 scFv fragment and lidamycin Binding of a biosynthetic intermediate to AtrA modulates the production of lidamycin by Streptomyces globisporus. Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027. Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027 Enediynes: Exploration of microbial genomics to discover new anticancer drug leads. Lidamycin inhibits tumor initiating cells of hepatocellular carcinoma Huh7 through GSK3β/β-catenin pathway Transarterial oily chemoembolization with lidamycin shows potent therapeutic efficacy in VX2 rabbit liver tumor A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis Chemiluminescent detection of cell apoptosis enzyme by gold nanoparticle-based resonance energy transfer assay A Gelatinases-targeting scFv-based Fusion Protein Shows Enhanced Antitumour Activity with Endostar against Hepatoma Lidamycin up-regulates the expression of thymidine phosphorylase and enhances the effects of capecitabine on the growth and pulmonary metastases of murine breast carcinoma Chloroquine potentiates the anti-cancer effect of lidamycin on non-small cell lung cancer cells in vitro Synergy of enediyne antibiotic lidamycin and temozolomide in suppressing glioma growth with potentiated apoptosis induction Draft genome sequence of Streptomyces globisporus C-1027, which produces an antitumor antibiotic consisting of a nine-membered enediyne with a chromoprotein Antibiotic Activity of Actinobacteria from the Digestive Tract of Millipede (Diplopoda) A bispecific enediyne-energized fusion protein targeting both epidermal growth factor receptor and insulin-like growth factor 1 receptor showing enhanced antitumor efficacy against non-small cell lung cancer An arginine-rich cell penetrating peptide contained anti-gelatinase scFv-LDM fusion protein shows potent antitumor efficacy in pancreatic cancer. Selective tumor killing based on specific DNA-damage response deficiencies An engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy EGFR-targeting, β-defensin-tailored fusion protein exhibits high therapeutic efficacy against EGFR-expressed human carcinoma via mitochondria-mediated apoptosis Simultaneous determination of lidamycin enediyne chromophore (LDC) and its aromatized derivative (LDCA) using puerarin as internal standard in rat plasma by LC-MS/MS. Radio-frequency ablation-based studies on VX2rabbit models for HCC treatment. A novel antibody-drug conjugate anti-CD19(Fab)-LDM in the treatment of B-cell non-Hodgkin lymphoma xenografts with enhanced anticancer activity Factor VII light chain-targeted lidamycin shows intensified therapeutic efficacy for liver cancer Role of prosurvival molecules in the action of lidamycin toward human tumor cells EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells A novel enediyne-integrated antibody-drug conjugate shows promising anti-tumor efficacy against CD30+ lymphomas. A CD13-targeting peptide integrated protein inhibits human liver cancer growth by killing cancer stem cells and suppressing angiogenesis Ribosome engineering and fermentation optimization leads to overproduction of tiancimycin A, a new enediyne natural product from Streptomyces sp. CB03234. Site-specific PEGylation of lidamycin and its antitumor activity Enediyne-activated, EGFR-targeted human β-defensin 1 has therapeutic efficacy against non-small cell lung carcinoma Lidamycin decreases CD133 expression in hepatocellular carcinoma via the Notch signaling pathway. An albumin‑binding domain and targeting peptide‑based recombinant protein and its enediyne‑integrated analogue exhibit directional delivery and potent inhibitory activity on pancreatic cancer with K‑ras mutation Small antibody fusion proteins with complementarity-determining regions and lidamycin for tumor targeting therapy Internal enhancement of DNA damage by a novel bispecific antibody-drug conjugate-like therapeutics via blockage of mTOR and PD-L1 signal pathways in pancreatic cancer

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