About: A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism

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About: A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism Goto Sponge NotDistinct Permalink

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scientific article published on 31 July 2008

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2008 (ast) наукова стаття, опублікована в липні 2008 (uk) scientific article published on 31 July 2008 (en) مقالة علمية نشرت في 31 يوليو 2008 (ar)
publication date	wds:Q37034874-C274C3A0-C9BB-4532-9193-A8C382785E9A
publication date	2008-07-31 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37034874-611D7211-9C4E-41BB-85E0-B500803A4729
language of work or name	English
cites work	wds:Q37034874-035D9821-1A47-47F4-99B2-5CEE0E1B1C3B wds:Q37034874-0FBA5F82-E8D5-4FF1-AA6D-AB9DB18D3DD6 wds:Q37034874-270CA1D3-2A88-41FC-80BF-5F8B02A0E5AD wds:Q37034874-2AA9FFE4-FC59-499E-8ADF-75532847845A wds:Q37034874-2FB14117-83AC-4D4B-B44B-B467F757174A wds:Q37034874-33A0E65D-BC71-4A88-A54A-0AA9433CD8FF wds:Q37034874-37814BC2-B049-47FC-8E8F-AF1B70931E36 wds:Q37034874-4C643EB1-4DEF-4EDE-85E1-1200D16651D4 wds:Q37034874-51F82A4A-D686-4833-9EB0-F6EF38B33184 wds:Q37034874-57586D87-79AD-4F72-8CD0-3362B6EC7308 wds:Q37034874-62134B2C-2771-419A-97E9-5B089EAD70D9 wds:Q37034874-651128F3-F97F-452A-A55A-FCFD14A35A40 wds:Q37034874-7FA3A94F-0B3C-4CA3-9055-9213707E9448 wds:Q37034874-8DF9BBD3-133D-49F2-B65A-FBA7354A170B wds:Q37034874-B807009A-204D-41CF-A0CB-15B948A6673D wds:Q37034874-C132C60D-9824-4860-96DC-627444D07373 wds:Q37034874-C25B1DEC-10FE-4B07-80A5-7B09C1A7BA1E wds:Q37034874-C96ACB1E-3E9E-4448-86F3-B89BE610D3C6 wds:Q37034874-CE9FA689-073B-4CDB-A4A4-1951D99BF8A5 wds:Q37034874-CFAA36A2-6565-443C-A25A-C022044F4532 wds:Q37034874-D2272D46-15E9-4714-B8F4-199612395F2E wds:Q37034874-E4953693-AE62-44E2-B1E7-DE808DAA5932 wds:Q37034874-ED286C55-9F52-4F21-A807-1FF8AED8580D wds:Q37034874-F437EA67-2CE8-4ABB-B4B9-CE1752FDD050 wds:Q37034874-FBBBCCB0-D094-4105-B388-3EB66678A298 wds:Q37034874-FC54BD8D-6EF4-4186-A189-32F607857FD1 wds:Q37034874-FDFCC761-400A-4F45-A1F6-DEBD5DCC3413
cites work	Crystal Structure of a Thermally Stable Rhodopsin Mutant Overcoming the inadequacies or limitations of experimental structures as drug targets by using computational modeling tools and molecular dynamics simulations Virtual ligand screening: strategies, perspectives and limitations Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function Main-chain bond lengths and bond angles in protein structures Drug design strategies for targeting G-protein-coupled receptors The lutropin/choriogonadotropin receptor, a 2002 perspective The Lutropin/Choriogonadotropin Receptor, A 2002 Perspective Ligand docking and structure-based virtual screening in drug discovery High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor Crystal structure of the human beta2 adrenergic G-protein-coupled receptor Crystal structure of rhodopsin: A G protein-coupled receptor Structure of human follicle-stimulating hormone in complex with its receptor Crystal structure of a photoactivated deprotonated intermediate of rhodopsin Structural biology and drug discovery Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships A molecular dissection of the glycoprotein hormone receptors. Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G). A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR). Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor G protein-coupled receptors: in silico drug discovery in 3D. Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor Adaptation to blockade of human immunodeficiency virus type 1 entry imposed by the anti-CCR5 monoclonal antibody 2D7. Generation of a homology model of the human histamine H3 receptor for ligand docking and pharmacophore-based screening
author name string	wds:Q37034874-589B0CB5-0CAE-4331-BE5C-D5008DE9A699 wds:Q37034874-5CF13858-90EF-4D56-9637-4F5DE49E2DFC wds:Q37034874-8D9B63F0-CF86-4D77-BD21-F4EDC35608F3 wds:Q37034874-9E0EBBB6-E03C-49EA-A2C9-DEB95B7E17C4 wds:Q37034874-A857CA47-0928-482E-91E8-5867381E623C wds:Q37034874-BDF1CCAF-18D4-4B35-B5AF-929D13906838 wds:Q37034874-DC66A0D3-AC9A-46A6-B1FC-C91F2897A72E wds:Q37034874-EF131C1A-98C3-4079-93FB-F20B6E47F637 wds:Q37034874-F91DCA58-56F1-48E8-B79B-D0F3C0410E20
author name string	Gunnar Kleinau Craig J Thomas Stefano Costanzi Gerd Krause Bruce M Raaka Marvin C Gershengorn Jian-kang Jiang Susanne Neumann Susanna Moore
rdfs:label	A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. (nl) A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism (en) A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism (ast)
skos:prefLabel	A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. (nl) A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism (en) A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism (ast)
name	A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. (nl)

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