About: The human bile salt export pump: characterization of substrate specificity and identification of inhibitors

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rdf:type	Item
description	artículu científicu espublizáu en 2002 (ast) vědecký článek publikovaný v roce 2002 (cs) наукова стаття, опублікована в листопаді 2002 (uk) 2002 թվականի նոյեմբերին հրատարակված գիտական հոդված (hy) 2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած (hyw) مقالة علمية (نشرت في نوفمبر 2002) (ar) vedecký článok (publikovaný 2002/11/01) (sk) wetenschappelijk artikel (gepubliceerd op 2002/11/01) (nl) مقالة علمية تنشرت ف 1 نونبر 2002 (ary) article scientifique publié en 2002 (fr) im November 2002 veröffentlichter wissenschaftlicher Artikel (de) scientific journal article (en)
publication date	wds:Q28612066-1B1BC0C1-BF63-4885-8B30-C96845B66FCA
publication date	2002-11-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28612066-9EF804C9-4609-4079-9FD4-BC4B5C7C8136
language of work or name	English
author name string	wds:Q28612066-0ED6A937-EA37-414E-AC86-B7F4AC336CFD wds:Q28612066-78C94BD0-A35E-4F26-A738-7734EE9A56EB wds:Q28612066-8592CAAE-89FE-447C-AB46-41F876DF8538 wds:Q28612066-93511AD0-CFA1-494A-8E81-8A04988AF5BE wds:Q28612066-C5CBE3B5-BB8D-4457-AE0F-23F18C034B6C wds:Q28612066-E73A7A28-FEB3-490B-A8CD-E0FB233AE4E2
OpenCitations bibliographic resource ID	wds:Q28612066-1E84AD17-2994-4023-82AA-69585AAE09EB
OpenCitations bibliographic resource ID	https://w3id.org/oc/corpus/br/4109336
author name string	Giorgina Mieli-Vergani Christopher F. Higgins Jane A. Byrne Kenneth J. Linton Richard J. Thompson Sandra S. Strautnieks
OpenCitations bibliographic resource ID	4109336
rdfs:label	The human bile salt export pump: characterization of substrate specificity and identification of inhibitors (en) The human bile salt export pump: characterization of substrate specificity and identification of inhibitors (nl) The human bile salt export pump: characterization of substrate specificity and identification of inhibitors (ast)
skos:prefLabel	The human bile salt export pump: characterization of substrate specificity and identification of inhibitors (en) The human bile salt export pump: characterization of substrate specificity and identification of inhibitors (nl) The human bile salt export pump: characterization of substrate specificity and identification of inhibitors (ast)
name	The human bile salt export pump: characterization of substrate specificity and identification of inhibitors (en) The human bile salt export pump: characterization of substrate specificity and identification of inhibitors (nl) The human bile salt export pump: characterization of substrate specificity and identification of inhibitors (ast)
title	wds:Q28612066-A2372739-FCE1-4FE3-ABC0-A7927F11C285
title	The human bile salt export pump: characterization of substrate specificity and identification of inhibitors (en)
page(s)	wds:Q28612066-749661A8-1C42-4A0E-AD91-E4791360050D
page(s)	1649–1658
instance of	wds:Q28612066-623E4CED-70C4-4433-9CEA-A8CFB3B3B8FF
instance of	scholarly article
PubMed ID	wds:Q28612066-D32314B4-573F-4257-81CF-6DBE20AE64B2
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12404239
PubMed ID	12404239
published in	wds:Q28612066-3377D984-8876-44BF-8D91-6E2850329D22
published in	Gastroenterology
issue	wds:Q28612066-BD8AF024-2CDC-4284-B0F5-5AFC7A223B5A
volume	wds:Q28612066-4157DA4B-01C2-4DAF-9225-E69D230BBE81
issue	5
volume	123
DOI	wds:Q28612066-4263ADE1-2CF0-4F9F-96A3-02B3F7B1BFE9
DOI	http://dx.doi.org/10.1053/GAST.2002.36591
DOI	10.1053/GAST.2002.36591
ResearchGate publication ID	wds:Q28612066-D4212348-B254-4636-BA1D-F440A66FB854
ResearchGate publication ID	11060250
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q28612066
is cites work of	Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency Bile acid transporters: structure, function, regulation and pathophysiological implications The bile salt export pump Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump Hepatobiliary transporters and drug-induced cholestasis Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep. Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression Xenobiotic, bile acid, and cholesterol transporters: function and regulation. The bile salt export pump: molecular properties, function and regulation Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11. 4-phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps Bile acid transporters Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicing Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases A progressive familial intrahepatic cholestasis type 2 mutation causes an unstable, temperature-sensitive bile salt export pump. Lack of hepatocellular CD10 along bile canaliculi is physiologic in early childhood and persistent in Alagille syndrome. Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver. Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis Detergent screening and purification of the human liver ABC transporters BSEP (ABCB11) and MDR3 (ABCB4) expressed in the yeast Pichia pastoris Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury Characterization of mutations in ATP8B1 associated with hereditary cholestasis Heterologous overexpression and mutagenesis of the human bile salt export pump (ABCB11) using DREAM (Directed REcombination-Assisted Mutagenesis). The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease Influence of seeding density and extracellular matrix on bile Acid transport and mrp4 expression in sandwich-cultured mouse hepatocytes. Hepatotoxicity Related to Anti-tuberculosis Drugs: Mechanisms and Management The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes Bile acid transporters in health and disease Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide Bile Acid sulfation: a pathway of bile acid elimination and detoxification Endogenous ursodeoxycholic acid and cholic acid in liver disease due to cystic fibrosis. Sepsis and cholestasis Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability Bile formation and secretion Canalicular ABC transporters and liver disease Integration of preclinical and clinical data with pharmacokinetic modeling and simulation to evaluate fexofenadine as a probe for hepatobiliary transport function

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