About: A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2

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About: A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2 Goto Sponge NotDistinct Permalink

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description	artículu científicu espublizáu en 2009 (ast) vědecký článek publikovaný v roce 2009 (cs) наукова стаття, опублікована в жовтні 2009 (uk) 2009 թվականի հոտեմբերին հրատարակված գիտական հոդված (hy) 2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած (hyw) vedecký článok (publikovaný 2009/10/23) (sk) wetenschappelijk artikel (gepubliceerd op 2009/10/23) (nl) مقالة علمية (نشرت في 23-10-2009) (ar) article publié dans la revue scientifique Journal of Biological Chemistry (fr) im Oktober 2009 veröffentlichter wissenschaftlicher Artikel (de) scientific journal article (en)
publication date	wds:Q28591744-56289FBF-D832-413D-921B-A0AEFD1731CE
publication date	2009-10-23 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28591744-160F16F6-6A8E-4776-B17C-C540AADE3B1C
language of work or name	English
cites work	wds:Q28591744-05656A70-1799-4C41-9694-FBDE372EA7F3 wds:Q28591744-094DBC48-E73D-4B2D-A9DF-BE6C5BDEE796 wds:Q28591744-0ACF8234-9480-4845-B1F3-63C2D41FDDD0 wds:Q28591744-0B69744E-F0BF-4647-9944-3852C7328020 wds:Q28591744-16EF4D48-93A0-4D77-AAF9-886A42AA96DB wds:Q28591744-1F16FA26-2CD9-4FA9-A389-88C31007D628 wds:Q28591744-37E74AFE-6BCA-4CD2-96FE-68B926553AC5 wds:Q28591744-3AFFA7BC-68DE-4EDD-9A67-DA2220B754E8 wds:Q28591744-414E7FCF-588F-4718-B2A9-CFDE356611FF wds:Q28591744-596EDA0B-CFC6-40CA-A758-1F90EC272D13 wds:Q28591744-6B4BF34D-DB00-4B0A-A4A9-F3D124A44977 wds:Q28591744-6BB1E76A-598C-4B70-AFB9-1049ACAC578B wds:Q28591744-6DFD8E46-8F1B-4BE1-B71F-5BDF70CE1AE8 wds:Q28591744-700625A6-DA06-4122-8F9D-D3AF152966F7 wds:Q28591744-7357261D-91EE-4FB2-A3EF-1FD8D7DB686B wds:Q28591744-73672054-3710-4385-ACF2-42022CF3B168 wds:Q28591744-83B08616-5912-4CD7-B735-84C1928D6891 wds:Q28591744-93F6A0F4-90E2-4B67-9365-A2558A5349C0 wds:Q28591744-94EE1884-6FC2-4D0B-9407-18C3E5CAD912 wds:Q28591744-9ACA3E06-52B2-4A7A-9D5C-8A231624DA81 wds:Q28591744-A2390802-ABE4-4079-B8BA-920BC05362AA wds:Q28591744-B4A0B4DB-068B-4799-BA6B-7FFC6AF72815 wds:Q28591744-C638D87C-1A97-4DA9-B0B8-BF75B89A6FB8 wds:Q28591744-C9CDA8F5-1B15-49D9-A1A0-C4E0F0906240 wds:Q28591744-CD67C56D-5618-4C34-A704-13243E77017D wds:Q28591744-CF62E627-DEA6-4518-81B0-CE1E57B771EC wds:Q28591744-DFEBE701-93F9-46AF-9CE9-BED68F2FAAB7 wds:Q28591744-E1EFC016-846D-417C-8EC2-6CB012DD0327 wds:Q28591744-EEFE2CF0-8BC6-4D95-A0A4-628A596D2AF9 wds:Q28591744-F01749DB-25F6-44E7-9B29-5A38285D4437 wds:Q28591744-F5FD6A04-A378-4CAD-ACED-8F3113553DF5 wds:Q28591744-F7368271-FA0A-4359-9F5B-6AF340E2D6CE
cites work	The fatty liver dystrophy (fld) mutation. A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men. Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically Phosphatidic acid mediates demyelination in Lpin1 mutant mice Regulation of the translocation of phosphatidate phosphohydrolase between the cytosol and the endoplasmic reticulum of rat liver. Effects of unsaturated fatty acids, spermine, nucleotides, albumin and chlorpromazine Characterization and assay of phosphatidate phosphatase Characterization of the peripheral neuropathy in neonatal and adult mice that are homozygous for the fatty liver dystrophy (fld) mutation Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood. The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL. Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene. Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases Roles for lipid phosphate phosphatases in regulation of cellular signaling Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme Signaling functions of phosphatidic acid. Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2 Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1. Lipin, a lipodystrophy and obesity gene Chronic recurrent multifocal osteomyelitis: a concise review and genetic update Autoinflammatory bone disorders Homozygous mutations in LPIN2 are responsible for the syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia (Majeed syndrome). Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice Phosphatidic acid phosphohydrolase in the regulation of inflammatory signaling Effects of okadaic acid on the activities of two distinct phosphatidate phosphohydrolases in rat hepatocytes. A splice site mutation confirms the role of LPIN2 in Majeed syndrome.
author name string	wds:Q28591744-2238A93D-D8AD-4E54-B3EF-1F71C8F60455 wds:Q28591744-321D144E-A91D-4D90-AB9B-4831C08B41D9 wds:Q28591744-CA1417AA-4047-40BA-8A6D-02F7260F5945 wds:Q28591744-DD409681-996B-40E0-8239-60A772893590 wds:Q28591744-DE75089E-81D1-454A-8B6D-5DC3B9E925E2 wds:Q28591744-EEA634E1-0883-4053-8FEB-F7E7B7316788 wds:Q28591744-EFC0BE86-80BA-4D81-8E15-5217230CEEC8
OpenCitations bibliographic resource ID	wds:Q28591744-F214455F-B652-4377-BC3D-B6AB2C19D8C2
OpenCitations bibliographic resource ID	https://w3id.org/oc/corpus/br/1301141
author name string	Samantha Wong David N. Brindley Jay Dewald Lauren O'Loughlin Peixiang Zhang Bernard P. C. Kok Jimmy Donkor
OpenCitations bibliographic resource ID	1301141
rdfs:label	A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2 (en) A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2 (nl) A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2 (ast)

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