About: Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma

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About: Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma Goto Sponge NotDistinct Permalink

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scientific journal article

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rdf:type	Item
description	artículu científicu espublizáu en 2008 (ast) vědecký článek publikovaný v roce 2008 (cs) наукова стаття, опублікована в липні 2008 (uk) 2008 թվականի հուլիսին հրատարակված գիտական հոդված (hy) 2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած (hyw) vedecký článok (publikovaný 2008/07/14) (sk) wetenschappelijk artikel (gepubliceerd op 2008/07/14) (nl) im Juli 2008 veröffentlichter wissenschaftlicher Artikel (de) scientific journal article (en) مقالة علمية (نشرت في 14-7-2008) (ar)
publication date	wds:Q28589317-66B177EC-7836-418F-970F-08D328246C43
publication date	2008-07-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28589317-1A793E72-57E9-4ABD-94C5-F91AC7128563
language of work or name	English
cites work	wds:Q28589317-06A8BC8A-41F1-4CE0-8BC9-062A70305B4F wds:Q28589317-123255E6-8E2C-47D9-B134-9609D6CC61EE wds:Q28589317-13570053-938E-4D1C-8BE9-3CC8A0D93039 wds:Q28589317-1DBACB95-6AA7-4FBF-9AE9-9EBB08CD3394 wds:Q28589317-2CC9FD34-6808-45FD-B324-139B2AAFAFA7 wds:Q28589317-2E474243-8314-4698-8145-9A9C9D8211C1 wds:Q28589317-2FEE2AED-6999-4B70-9139-4C950FB60A69 wds:Q28589317-3E2F52F2-A1F6-44A9-859A-667C795E4506 wds:Q28589317-4063A829-55D3-4FE8-A6A0-D8D12964C818 wds:Q28589317-483AE403-69EB-4DD6-BAEF-6F79D80BC104 wds:Q28589317-549B0B70-FB9B-4C4C-B61B-5249AD8718E5 wds:Q28589317-612279E6-C8B1-4D2E-B7D6-9ACB4CD26FE5 wds:Q28589317-6E59892D-EFF9-4080-A625-D248A79AE981 wds:Q28589317-731E08AD-9072-4E31-9585-7822A295E734 wds:Q28589317-7ACBED0E-77E9-434F-8972-A01188FD0139 wds:Q28589317-8BF877C6-6586-4FA3-8167-442FD61EEEC9 wds:Q28589317-8FC37BEE-184F-4B02-8B26-550EA213E466 wds:Q28589317-AA590873-5480-4698-958F-CC36E048B5E7 wds:Q28589317-B1E59710-9347-45AE-96E3-54A79BF78EDE wds:Q28589317-B482EEE9-BAF7-438E-9932-486DE25CF242 wds:Q28589317-C946984D-C23E-4ADF-AFD9-9176EDEA5485 wds:Q28589317-CE4C3E3F-9951-4973-AD8A-5ABA09ECF8A6 wds:Q28589317-CEFCB2E5-689B-4E8C-A294-95C63955CC63 wds:Q28589317-D5130E53-B832-4A92-84A8-DAE1420DC4C8 wds:Q28589317-DC372E90-3775-4E2B-AEE7-1AB67D0915DE wds:Q28589317-E080FE71-EF97-4D50-9B9B-04679E68AEA3 wds:Q28589317-E10CBF1F-8C6B-4DDE-92C0-5DC56430E0B4 wds:Q28589317-EBEBD544-6979-427A-9D33-409306EA6D67 wds:Q28589317-F90648AD-4FA0-4F85-84D3-844331FED559 wds:Q28589317-FAA81EB5-6AE7-4AD7-A86A-FEB0B10FD84D
cites work	The ubiquitin-specific protease USP28 is required for MYC stability Nucleophosmin is required for DNA integrity and p19Arf protein stability N-terminal polyubiquitination and degradation of the Arf tumor suppressor Non-transcriptional control of DNA replication by c-Myc Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation. Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation Nucleophosmin regulates the stability and transcriptional activity of p53 Major nucleolar proteins shuttle between nucleus and cytoplasm p19ARF directly and differentially controls the functions of c-Myc independently of p53. Detection of normal and chimeric nucleophosmin in human cells Role of nucleophosmin in embryonic development and tumorigenesis Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Nucleolar protein B23 has molecular chaperone activities Transcriptional regulation and transformation by Myc proteins Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone Role of post-translational modifications in regulating c-Myc proteolysis, transcriptional activity and biological function c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations. Regulation of the cell cycle by SCF-type ubiquitin ligases Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin The proto-oncogene c-myc in hematopoietic development and leukemogenesis Cytoplasmic localization of NPM in myeloid leukemias is dictated by gain-of-function mutations that create a functional nuclear export signal.
author name string	wds:Q28589317-4A5AA3A5-C143-4E83-BD6F-AFE995CBF04E wds:Q28589317-AE4A7913-52A9-4944-9A1D-26EF3843BBCC wds:Q28589317-E5B545EF-1530-49C1-8C99-2DDF17E09B46 wds:Q28589317-E5C5CCB0-8523-4EC7-914F-597F804E8D5E
OpenCitations bibliographic resource ID	wds:Q28589317-D3D251F7-5AA7-4F26-9EC3-D4A72F10316F
OpenCitations bibliographic resource ID	https://w3id.org/oc/corpus/br/3922385
author name string	Pier Giuseppe Pelicci Emanuela Colombo Teresa Davoli Cristina Sironi
OpenCitations bibliographic resource ID	3922385
rdfs:label	Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma (en) Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma (nl) Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma (ast)
skos:prefLabel	Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma (en) Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma (nl) Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma (ast)
name	Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma (en) Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma (nl) Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma (ast)
author	wds:Q28589317-0EFD2A0D-A13A-434B-9441-358FFFF14812 wds:Q28589317-3878444C-7B74-407B-A621-C973A8205E17
author	Bruno Amati Paola Bonetti
title	wds:Q28589317-F350585B-31FD-42FC-86D7-8733FB235A0D

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