About: Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene

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About: Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene Goto Sponge NotDistinct Permalink

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description	artículu científicu espublizáu en 2001 (ast) vědecký článek publikovaný v roce 2001 (cs) 2001 թվականի նոյեմբերին հրատարակված գիտական հոդված (hy) наукова стаття, опублікована в листопаді 2001 (uk) 2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած (hyw) 2001年學術文章 (zh) vedecký článok (publikovaný 2001/11/20) (sk) wetenschappelijk artikel (gepubliceerd op 2001/11/20) (nl) مقالة علمية (نشرت في 20-11-2001) (ar) article publié dans les Proceedings of the National Academy of Sciences of the United States of America (fr) im November 2001 veröffentlichter wissenschaftlicher Artikel (de) scientific journal article (en)
publication date	wds:Q28588943-768EC8EE-8D32-4C88-930F-A11B89F17E8D
publication date	2001-11-20 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28588943-F30D1A8A-D921-4EB1-B9A7-F0A883FB2CEF
language of work or name	English
cites work	wds:Q28588943-05A808B9-7155-429B-8F34-E7EE6A11E2EE wds:Q28588943-0C36864B-D8D1-4100-8A48-A5765B3D6952 wds:Q28588943-18C6A62E-1816-4D14-BF76-9539FCBC1B34 wds:Q28588943-2580D8DF-45C7-4E49-A22C-7599B38E273B wds:Q28588943-297BAE84-23C6-4521-A4E2-684A7D9CD34F wds:Q28588943-2FF07004-2D64-4A0E-9C48-7EC5D75233CE wds:Q28588943-36AB333B-11AC-4FEE-A53B-2101092F869E wds:Q28588943-4273CCAD-2534-4475-81E2-E84C674775E8 wds:Q28588943-44219FE6-16ED-4A1E-B437-EB6B236A93FE wds:Q28588943-44E408CA-00D0-4146-88DF-2BE12D1689EB wds:Q28588943-4E09C2F4-F03D-48B3-9536-90E7FF2BD3DB wds:Q28588943-5B58C19D-9181-4D04-B81B-08EE636BC088 wds:Q28588943-7130D4C6-3CFB-4A25-AECA-910754A4054F wds:Q28588943-7B6F01B5-FDE8-4F21-A824-06C179E65DFC wds:Q28588943-824800BF-61D8-4FF5-B2C2-D94A73A7B713 wds:Q28588943-85D9E750-56F7-4E83-A57E-8CE16FDF66A1 wds:Q28588943-883D5184-6D4C-4AA5-B555-EA7430DEAD87 wds:Q28588943-8884CDC0-2B77-4C12-A149-0221D656FCEF wds:Q28588943-8892EE28-BF44-4E9E-BA82-CF8CF88B62B0 wds:Q28588943-8E7F24C6-1F1F-4C7E-B80B-332F1F60CA1C wds:Q28588943-982990A6-6850-4D76-8506-FA1A1106C3AA wds:Q28588943-9E1215A9-8248-4A94-9F52-7573BBFF6D33 wds:Q28588943-AD959EB9-53C3-43BA-BB81-059E9CF867EC wds:Q28588943-B48BD5B6-5405-4296-B13F-FFC7085AD0BD wds:Q28588943-CBD125E2-82F0-4753-8755-618D60750F31 wds:Q28588943-D0141114-E201-4E9F-AB00-817597506E79 wds:Q28588943-D8710544-F5B5-44C1-AFB9-128DF634E73D wds:Q28588943-D9C10154-3D0F-4352-9745-BA14B99FC83F wds:Q28588943-DE8253A1-2B18-479B-9CE3-0594B6FB443F wds:Q28588943-E2E8DF45-6F22-4066-9C85-37F5A0959901 wds:Q28588943-EA7D2EFC-819E-486D-8F00-445CDDB18C09 wds:Q28588943-F2521CAD-3E99-4B4B-9855-4FD6F750540B wds:Q28588943-F7E5F0F6-1343-44F5-9CB5-18D1E42166A2
cites work	SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. 19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cells Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes Inducible gene targeting in mice Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells Functional analysis of secreted and transmembrane proteins critical to mouse development. Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2) Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2. Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2. Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins. Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.
author name string	wds:Q28588943-0A797F20-099B-4391-9A0F-2C1D36F47EF3 wds:Q28588943-0AD74622-B9F7-4D59-A1BD-1FCFD9747F20 wds:Q28588943-89DDB974-ACAD-43F6-A0FA-BA2793E30406 wds:Q28588943-B4BF3DDD-C842-4E2B-A57B-5F33230BEB95 wds:Q28588943-C0275DC7-2DEC-4980-AAE3-3EC8A939D9A3 wds:Q28588943-F0469B3C-8AA4-42BB-B32D-B072AC415A59
OpenCitations bibliographic resource ID	wds:Q28588943-9392F700-B4D5-46D8-9909-7DB138A69994
OpenCitations bibliographic resource ID	https://w3id.org/oc/corpus/br/2566192
author name string	M. S. Brown J. Yang J. L. Goldstein J. D. Horton R. E. Hammer Y. A. Moon
OpenCitations bibliographic resource ID	2566192
rdfs:label	Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene (en) Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene (nl)

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