About: Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number

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About: Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number Goto Sponge NotDistinct Permalink

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description	artículu científicu espublizáu en 2003 (ast) vědecký článek publikovaný v roce 2003 (cs) 2003 թվականի օգոստոսին հրատարակված գիտական հոդված (hy) 2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած (hyw) наукова стаття, опублікована в серпні 2003 (uk) im August 2003 veröffentlichter wissenschaftlicher Artikel (de) wetenschappelijk artikel (gepubliceerd op 2003/08/14) (nl) vedecký článok (publikovaný 2003/08/14) (sk) مقالة علمية (نشرت في 14-8-2003) (ar) scientific journal article (en)
publication date	wds:Q28584893-A493BC7E-8193-4CE1-8EEE-FAE17FDC9FC6
publication date	2003-08-14 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28584893-C58AFEC6-FF46-473D-AEEF-9821D80ED69D
language of work or name	English
cites work	wds:Q28584893-09EA5DF3-F841-48B8-800A-FC78C57EBFC5 wds:Q28584893-0E5E9DB3-7979-43FC-AA96-D9FC72D339B7 wds:Q28584893-381BD813-BB46-4292-B21A-4B4F4B2E4A3F wds:Q28584893-4296B107-1B30-4710-A902-B174D844D961 wds:Q28584893-45F8D3ED-7119-4524-91EF-475FFFA729AE wds:Q28584893-4E473380-7082-4304-A972-89E2A878EB24 wds:Q28584893-562547A7-58C3-401C-B43B-DE937605B6FA wds:Q28584893-5AA1E302-AEDB-4151-8990-66DEB5A2F71B wds:Q28584893-6C014E1B-8C38-42CE-A639-BD6C0F7E9D5D wds:Q28584893-6EB62220-39D4-4D51-8FF7-DBE012E98434 wds:Q28584893-75DAA2C0-E0E0-41C2-808F-14BB31592D3D wds:Q28584893-87543026-2AEC-42A8-AD96-A4EC697A29E4 wds:Q28584893-9C92F750-5380-4DD5-9290-29430A76987C wds:Q28584893-A0453F93-B4A2-4A23-9100-B7E336DBE313 wds:Q28584893-A456A403-967F-4345-9B00-9D666EA05E1D wds:Q28584893-A59FFFF5-09A9-4F7F-9016-5290B70F9021 wds:Q28584893-A64C71AB-F1FC-4C03-AC1A-20CBDB05E381 wds:Q28584893-A8C79341-A439-4113-87A0-918CF1FEA62F wds:Q28584893-A9D566DA-2327-4346-9950-F0054F780480 wds:Q28584893-AE9F04F2-C156-4DE9-A876-1F91E8279D7C wds:Q28584893-B3E3F39B-FF1A-4633-B82B-70542D0AE894 wds:Q28584893-B5188FBF-9E9C-423E-BC50-DB709012281A wds:Q28584893-B60B0DCE-079F-4468-B7F9-09ADC2C43390 wds:Q28584893-B9617383-402E-4336-9D7B-3CF192AF60C6 wds:Q28584893-C40D4A0E-74DD-4586-8CED-1D1F2F17BA56 wds:Q28584893-D6EC2989-49A5-4C9F-BE66-871AA5CB22A7 wds:Q28584893-E440B72B-D94D-4A4D-B66A-10E88FCF9839 wds:Q28584893-F7E7AE55-D5E2-4DCF-85EF-53B188D5294C wds:Q28584893-FDD40461-AD28-444A-B0EE-202425E50324 wds:Q28584893-FEF0B56B-598C-411D-A9A2-B16BE9B2C441
cites work	Principles of CDK regulation Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors The regulation of E2F by pRB-family proteins Intercellular signals regulating pancreas development and function Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity The retinoblastoma protein and cell cycle control Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. G1 events and regulation of cell proliferation Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase CDK inhibitors: positive and negative regulators of G1-phase progression Life and death of the pancreatic beta cells Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression To cycle or not to cycle: a critical decision in cancer. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy. Islet growth and development in the adult Intact follicular maturation and defective luteal function in mice deficient for cyclin- dependent kinase-4. Invasive melanoma in Cdk4-targeted mice Treatment of periorbital wrinkles. A comparison of the SilkTouch carbon dioxide laser with a medium-depth chemical peel Pituitary Hypoplasia and Lactotroph Dysfunction in Mice Deficient for Cyclin-Dependent Kinase-4
author name string	wds:Q28584893-1B6AF504-0B9D-473C-A3CF-046D29EDB820 wds:Q28584893-1C53D816-2C7F-42B4-8047-840E50E781D1 wds:Q28584893-27923211-4A13-46B6-A1F8-563A0BC98BC9 wds:Q28584893-2FA53059-F603-4CDD-969D-6D0DC829593A wds:Q28584893-BCD204D0-59A9-4D65-91B7-0A13131261DB wds:Q28584893-C0B5411F-B1EE-4EB2-9B85-2066CF24F717 wds:Q28584893-FBE898F2-F39A-4688-9835-2D0B43F5875F
OpenCitations bibliographic resource ID	wds:Q28584893-9519E597-8F73-45C7-BDEB-BB30D54DB14F
OpenCitations bibliographic resource ID	https://w3id.org/oc/corpus/br/2448257
author name string	Mariano Barbacid Pierre Dubus Javier Martín Sagrario Ortega Albert F. Parlow Fanny Néhmé-Pélluard Sarah L. Hunt
OpenCitations bibliographic resource ID	2448257
rdfs:label	Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number (en) Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number (nl) Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number (ast)
skos:prefLabel	Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number (en) Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number (nl) Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number (ast)
name	Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number (en) Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number (nl)

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