About: Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes

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description	artículu científicu espublizáu en 2012 (ast) vědecký článek publikovaný v roce 2012 (cs) наукова стаття, опублікована у вересні 2012 (uk) مقالة علمية (نشرت في سبتمبر 2012) (ar) 2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած (hyw) 2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված (hy) wetenschappelijk artikel (gepubliceerd op 2012/09/01) (nl) vedecký článok (publikovaný 2012/09/01) (sk) 2012 സപ്തംബര്‍ 1 നു പ്രസിദ്ധീകരിച്ച ശാസ്ത്ര ലേഖനം (ml) scientific journal article (en) im September 2012 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q28580371-371CB5A9-8237-4153-8DE5-222D2433ED3A
publication date	2012-09-01 00:00:00Z (xsd:dateTime)
cites work	wds:Q28580371-1155A2F4-A15B-4BDD-B7BF-2F899AA8FCAD wds:Q28580371-14B4F860-3899-4C78-92A8-374AB01431F0 wds:Q28580371-24655528-805F-42C9-AD45-B6E881EE9771 wds:Q28580371-2659EB44-5171-4657-92F3-06FAFC42D64C wds:Q28580371-33E704F1-08A5-44B8-907F-B5276552CC03 wds:Q28580371-35B5AA90-D6C8-4D83-9849-27531CBC690A wds:Q28580371-38493941-811D-4630-AE6D-8E077D83D05C wds:Q28580371-449B79A1-CD5A-473E-B713-179178497D3B wds:Q28580371-533C6ABA-7116-4478-BFC2-347F094F2D47 wds:Q28580371-5548E077-4F4D-4B74-9ADB-A1943F6282F2 wds:Q28580371-568512FF-899E-44A3-8884-40F3BD189A7B wds:Q28580371-5AEACBB1-32A2-4248-924E-A561078642B6 wds:Q28580371-5EC858EA-71CE-4AC6-8DAF-F92F07A1C0C2 wds:Q28580371-67CCE74E-7C18-45CC-B226-4848F1DFA635 wds:Q28580371-746C50DC-BC73-4EFF-87EF-896EB25F6707 wds:Q28580371-7F253A83-1F71-4722-98E3-33A8990A8E52 wds:Q28580371-85A60142-4403-42FF-A517-113A1379725C wds:Q28580371-897277D1-2CC4-41CB-8A5F-32853E38C57E wds:Q28580371-8DFB0579-8405-4493-9186-FF7B75D7D7A1 wds:Q28580371-8EA0BD04-C38D-4780-A022-6202D29BA5FF wds:Q28580371-956D7129-7487-4C3E-A1F4-45F8EF7B9F96 wds:Q28580371-9E08E333-9239-4558-9CD2-A1FD8DB8595B wds:Q28580371-A05263E7-78B0-4550-B757-79169A09AD6B wds:Q28580371-A6F2FDE4-092B-48AE-9448-198736ECC109 wds:Q28580371-B5F27670-BA64-4765-88C7-F9689927F8BF wds:Q28580371-C190C72B-9686-4C16-97C9-14F6B178CF0D wds:Q28580371-C3CD8D64-4E77-424D-AE6D-30C9EA5A2AE3 wds:Q28580371-CFAA9131-1C44-42F1-B124-436014D1DFE4 wds:Q28580371-D01E3B92-DCAB-4853-87D5-C202028DA4A7 wds:Q28580371-D0A5CC29-CF23-439A-AE04-B978D2BC46DB wds:Q28580371-E4DB5CC2-92EA-4C31-B2ED-D04C8BAF2E7B wds:Q28580371-ECACBBDA-3B77-4EB9-A849-D068B385B36D wds:Q28580371-F4A7659D-EAE5-4418-96B9-DAE11FC1CBD7 wds:Q28580371-FFA304B1-AE26-4E99-9DF6-3CCCB34ECCAA
cites work	A conserved family of prolyl-4-hydroxylases that modify HIF Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase Myocardial ischemia differentially regulates LKB1 and an alternate 5'-AMP-activated protein kinase kinase HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress Glucose uptake and glycolysis reduce hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytes Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury Chutes and Ladders: the search for protein kinases that act on AMPK. Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}. Adenosine 5'-monophosphate-activated protein kinase and p38 mitogen-activated protein kinase participate in the stimulation of glucose uptake by dinitrophenol in adult cardiomyocytes Hypoxia and hypoxia/reoxygenation activate p65PAK, p38 mitogen-activated protein kinase (MAPK), and stress-activated protein kinase (SAPK) in cultured rat cardiac myocytes Prolyl hydroxylase inhibitor treatment confers whole-animal hypoxia tolerance Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation AMP-activated protein kinase: the guardian of cardiac energy status. The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes Rapid determination of creatine, phosphocreatine, purine bases and nucleotides (ATP, ADP, AMP, GTP, GDP) in heart biopsies by gradient ion-pair reversed-phase liquid chromatography Mechanism of acetylcholine-induced calcium signaling during neuronal differentiation of P19 embryonal carcinoma cells in vitro Dual mechanisms regulating AMPK kinase action in the ischemic heart. LKB1, an upstream AMPK kinase, regulates glucose and lipid metabolism in cultured liver and muscle cells
author name string	wds:Q28580371-661842D1-F485-448F-8191-6C93C3D3A6B7 wds:Q28580371-6D2CEC59-3F90-4888-B4DA-273F0FC18EFC wds:Q28580371-B754AE9A-C725-4D44-8440-91E0824F2811 wds:Q28580371-C5B429E7-6FE1-441E-A292-2F1CF19EE9BA wds:Q28580371-D15C2EF8-649A-423A-8C0F-23658493870A
author name string	Qiong Zhang Hong Yan Yue-Sheng Huang Xiaohua Shi Dong-Xia Zhang
rdfs:label	Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes (en) Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes (nl) Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes (ast)
skos:prefLabel	Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes (en) Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes (nl) Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes (ast)
name	Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes (en) Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes (nl)

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