About: deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes

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scientific journal article

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rdf:type	Item
description	artículu científicu espublizáu en 2003 (ast) vědecký článek publikovaný v roce 2003 (cs) 2003 թուականի Յունիսին հրատարակուած գիտական յօդուած (hyw) наукова стаття, опублікована в червні 2003 (uk) 2003 թվականի հունիսին հրատարակված գիտական հոդված (hy) مقالة علمية (نشرت في 5-6-2003) (ar) vedecký článok (publikovaný 2003/06/05) (sk) wetenschappelijk artikel (gepubliceerd op 2003/06/05) (nl) im Juni 2003 veröffentlichter wissenschaftlicher Artikel (de) scientific journal article (en)
publication date	wds:Q28510655-D9879F1E-23AE-45A1-9075-8F69ABDB0BC9
publication date	2003-06-05 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28510655-BF3C7565-65FB-4582-95F4-CEDD3345919B
language of work or name	English
cites work	wds:Q28510655-1D0C541B-3E36-4B04-8DBE-EB9869696B0E wds:Q28510655-21487BE3-DF10-4BC6-A3B2-E7BEC59BDF10 wds:Q28510655-2BF3E951-8389-4C7D-8A53-4D5F7EA15685 wds:Q28510655-39A9B14D-FCBA-4647-965F-E5F7203141ED wds:Q28510655-3A5D3D85-B67F-4F65-9C95-9E2C8E1158F1 wds:Q28510655-3BCC7F5D-24F4-4C06-AC63-253090C1EBA4 wds:Q28510655-4085D102-1B4A-4FB3-A013-118FA9D0AA65 wds:Q28510655-4595498C-E21F-452F-9BCD-06C00E38CC84 wds:Q28510655-48279D85-E5F9-42D4-9612-8C35BB22E00B wds:Q28510655-52A99273-CF59-4CD3-AADC-1078F41DB109 wds:Q28510655-593A3135-3129-495A-9B28-F031C835AF64 wds:Q28510655-70315079-CB41-490B-9F30-D6F8758C13E3 wds:Q28510655-73609958-5E53-49D6-9DF8-191FEB2A81BD wds:Q28510655-77D214D9-4742-4D09-969F-303C87730840 wds:Q28510655-837037C5-9538-473E-A659-272087E78962 wds:Q28510655-920666BE-7689-480B-B253-42E0D1BDCACE wds:Q28510655-9379BF95-2850-4511-9685-58D1106824F2 wds:Q28510655-A1191FF2-A27B-4A19-B638-622E2E4173FB wds:Q28510655-A3362A36-A529-4AB9-B98A-6621C9D0AED7 wds:Q28510655-A56FD20A-5C5E-40A7-B1BC-15D8F243CEAC wds:Q28510655-B09790CD-B37F-4B77-9EB2-15FAD4281590 wds:Q28510655-BE3CAC1A-47C2-4D43-A27F-4A1FDD342AC9 wds:Q28510655-D92900BB-252A-4881-8E63-8401435C3296 wds:Q28510655-EF4A8DBF-C4ED-4E1F-ACD3-3E3FD72A9145 wds:Q28510655-F9800342-A6CB-411E-A4B8-E85E35919634 wds:Q28510655-FA1DA3A1-06A3-449F-AD86-0AA93B5C08FF wds:Q28510655-FD9461C0-98C1-47E8-B154-4FE1A737CEF8
cites work	p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development p63 is a p53 homologue required for limb and epidermal morphogenesis p53 associates with and targets Delta Np63 into a protein degradation pathway Association of p63 with proliferative potential in normal and neoplastic human keratinocytes Sunburn and p53 in the onset of skin cancer Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours Identification of p53 as a sequence-specific DNA-binding protein p63 immunoreactivity in lung cancer: yet another player in the development of squamous cell carcinomas? AIS is an oncogene amplified in squamous cell carcinoma p63 and p73 transactivate differentiation gene promoters in human keratinocytes Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers High level expression of deltaN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)? p63 expression in normal skin and usual cutaneous carcinomas p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53 P63 and P73: P53 mimics, menaces and more p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes TAp63gamma (p51A) and dNp63alpha (p73L), two major isoforms of the p63 gene, exert opposite effects on the vascular endothelial growth factor (VEGF) gene expression. A second p53-related protein, p73L, with high homology to p73. Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. DeltaNp63 induces beta-catenin nuclear accumulation and signaling Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. CUSP/p63 expression in rat and human tissues Characterization of an autoantigen associated with chronic ulcerative stomatitis: the CUSP autoantigen is a member of the p53 family High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53. Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51
author name string	wds:Q28510655-26F2B796-CC76-4AC3-9A20-37F43C91C957 wds:Q28510655-6C99035F-3A23-4E98-B3B4-2FA42E95EC9A wds:Q28510655-9B80A987-973E-489F-B8CC-4F26590E7992 wds:Q28510655-ADF9EED0-7DF1-4FB6-9960-7144AEAF8628 wds:Q28510655-D51683D0-C171-4917-92E2-89B8A5340D22 wds:Q28510655-DE25CB43-9EAB-4094-B198-FD06FB71F985
author name string	Takashi Tokino Marian F. Young Wendy C. Weinberg Kathryn E. King Lela A. Lee Roshini M. Ponnamperuma
rdfs:label	deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes (en) deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes (nl) deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes (ast)
skos:prefLabel	deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes (en) deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes (nl) deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes (ast)
name	deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes (en) deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes (nl) deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes (ast)
author	wds:Q28510655-C8EC338D-09BE-4476-AFAA-31ECE54B6B20
author	Toshiharu Yamashita
title	wds:Q28510655-C6D397F8-6B94-478E-9C51-D9FF6C36D142
title	deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes (en)
page(s)	wds:Q28510655-0DC265AF-AD3B-4CD0-AF8D-4610E99969C2
page(s)	3635–3644
instance of	wds:Q28510655-B706A280-25B6-476F-A567-692F9A90681F
instance of	scholarly article
main subject	wds:Q28510655-CD799DC0-2952-440A-918C-8F0EEF571F48
main subject	keratinocyte

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