About: Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation

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About: Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation Goto Sponge NotDistinct Permalink

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scientific journal article

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rdf:type	Item
description	artículu científicu espublizáu en 2009 (ast) vědecký článek publikovaný v roce 2009 (cs) article scientifique publié en 2009 (fr) 2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված (hy) наукова стаття, опублікована в грудні 2009 (uk) 2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած (hyw) vedecký článok (publikovaný 2009/12/10) (sk) مقالة علمية (نشرت في 10-12-2009) (ar) scientific journal article (en) im Dezember 2009 veröffentlichter wissenschaftlicher Artikel (de) wetenschappelijk artikel (gepubliceerd op 2009/12/10) (nl)
publication date	wds:Q28508267-4AEDE5CE-4A4A-40CB-AAB8-E9DEF5E19A41
publication date	2009-12-10 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28508267-C6E76F83-AA04-4ED7-9448-01B2BD2FF63E
language of work or name	English
cites work	wds:Q28508267-17B11107-FAE1-4370-A19B-2250AED1F93D wds:Q28508267-1B679E4F-F214-4030-9BB1-D9211EA585C3 wds:Q28508267-2056C8E5-85A3-4B77-B2B1-E0B21C4A5738 wds:Q28508267-535829AC-4620-4B44-BD74-A793D0061B96 wds:Q28508267-53BCE867-9A21-4DA0-BAC5-702AB69097C9 wds:Q28508267-5C3A8CA1-29EA-4AD2-8F15-C05879C037A1 wds:Q28508267-5ED3DDA3-69C9-478D-BD42-33CDB131D214 wds:Q28508267-6FF4CCD3-887B-4ED8-B378-010688F5663F wds:Q28508267-73631BCE-8A84-494F-811D-133000E42D25 wds:Q28508267-795E0D5B-E17C-4293-A923-84743D639136 wds:Q28508267-86307309-1BA7-4A74-8EDC-46DE2E40CB0E wds:Q28508267-8FA5EECF-007E-4214-B3BC-4BF6049C6AA8 wds:Q28508267-98D90FE7-6406-44E7-96B3-DE73F2E237DD wds:Q28508267-9D7C4863-B4A9-466E-8534-220899A55DCA wds:Q28508267-A32528E7-CB78-4863-9CBF-679D9E5780B1 wds:Q28508267-A6AC0D77-0D02-48CB-96DA-886A8B6E5F02 wds:Q28508267-AA035BC8-2783-4BF0-8BEF-BC87993ED7A9 wds:Q28508267-C33AA996-F708-46A1-821C-28E76F79CE51 wds:Q28508267-C782A32A-4F5C-4F68-9606-F9DB80D5E425 wds:Q28508267-C8DFDE7A-B344-4D56-8DB6-1AC68B3ECE99 wds:Q28508267-D0C934C3-D340-4C3B-A11A-09EF0468BFFC wds:Q28508267-D6CC8C59-AFEC-4598-9F12-99E85E157C36 wds:Q28508267-DB33C0F2-6C18-49F0-A081-C483B2B8C6E9 wds:Q28508267-DD6033B5-F6E8-4BCA-A7CE-AC7646CE6D7F wds:Q28508267-F5678857-4611-405C-B965-FF640772BA59 wds:Q28508267-FBD6E891-84D7-42BB-8D2D-2F5EFB3B7C23
cites work	Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase D-type cyclin-dependent kinase activity in mammalian cells Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein. Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation. Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma Cyclin D1 amplification and expression in human breast carcinoma: correlation with histological prognostic markers and oestrogen receptor expression Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown Molecular biology of upper gastrointestinal malignancies Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability UBE1L causes lung cancer growth suppression by targeting cyclin D1. Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors The N-terminal regulatory domain of cyclin A contains redundant ubiquitination targeting sequences and acceptor sites Cyclin D1 gene (CCND1) mutations in endometrial cancer Uncovering residues that regulate cyclin D1 proteasomal degradation. Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286 Association of cyclin D1 expression with factors correlated with tumor progression in human hepatocellular carcinoma Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1. Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4 Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex
author name string	wds:Q28508267-01AE9D96-7D94-426E-9EFE-D084482358D5 wds:Q28508267-0F9D7B2B-497F-4064-A18D-D79083EBD3B4 wds:Q28508267-590148CA-3E37-4BC1-BDD3-86EBD7520F2C wds:Q28508267-DD4312CA-B38D-4AB8-8829-EFB980587C6E wds:Q28508267-FA5F3FA5-B4BE-4080-BD48-EF579B8465E5
author name string	E. Egan J. A. Diehl J. Kosak L. L. Pontano O. Barbash
rdfs:label	Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation (en) Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation (nl) Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation (ast)
skos:prefLabel	Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation (en) Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation (nl) Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation (ast)
name	Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation (en) Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation (nl) Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation (ast)
title	wds:Q28508267-7FD70F14-9D58-4CB6-ADDB-470CA4877DDE
title	Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation (en)
page(s)	wds:Q28508267-1B96FFAD-DAEB-49A6-A78B-6B28821FFA41
page(s)	4317–4325
instance of	wds:Q28508267-AA486C4F-A6A1-496F-9E74-7B12D0B4E876
instance of	scholarly article
main subject	wds:Q28508267-1AD60551-BE58-468E-B506-9676C110273D wds:Q28508267-3A9C28D9-F342-4A4F-B736-4DEA9DF2163E wds:Q28508267-73598EE0-D902-42BD-8647-79C19A3BC8B1 wds:Q28508267-90184E1F-AE13-4E8D-86DA-32C9EAF13117
main subject	Cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinase 4 ubiquitination

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