About: A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

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rdf:type	Item
description	artículu científicu espublizáu en 2008 (ast) vědecký článek publikovaný v roce 2008 (cs) наукова стаття, опублікована в листопаді 2008 (uk) 2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած (hyw) 2008 թվականի նոյեմբերին հրատարակված գիտական հոդված (hy) vedecký článok (publikovaný 2008/11/15) (sk) مقالة علمية (نشرت في 15-11-2008) (ar) scientific journal article (en) im November 2008 veröffentlichter wissenschaftlicher Artikel (de) wetenschappelijk artikel (gepubliceerd op 2008/11/15) (nl)
publication date	wds:Q28504576-D30F0E9A-BAA4-478B-8373-844219D2E326
publication date	2008-11-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28504576-4D4E83AC-27B6-4C18-878D-C36283530BE3
language of work or name	English
author name string	wds:Q28504576-00F4D31C-FB0C-486E-87B1-F9A6F0E30937 wds:Q28504576-01B0FD39-0514-4004-A101-421D1E1B2C77 wds:Q28504576-2666CE88-5315-440D-9678-1BAF45224AB2 wds:Q28504576-2ADE4897-EFB7-437E-93AD-E234249C5292 wds:Q28504576-4247951E-E04B-4CCF-A302-65CAAA067468 wds:Q28504576-478EDE4C-5452-4BA7-A136-A2F7929321C7 wds:Q28504576-73E58A79-ECF2-4CAA-B615-6FC49C3DE28F wds:Q28504576-8B16D12B-8199-4DED-A555-AE19EEBC2258 wds:Q28504576-E948715D-70E0-4B50-8636-58D58787C233 wds:Q28504576-FE57EF7C-4204-4142-8ED1-B6B833D181B4
author name string	Simon A Hawley Kei Sakamoto Alan Ashworth Sarah Fogarty Afshan McCarthy David A Pan Selva B Cigorraga María N Galardo Silvina B Meroni Nicolas A Morrice
rdfs:label	A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis (en) A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis (nl) A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis (ast)
skos:prefLabel	A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis (en) A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis (nl) A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis (ast)
name	A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis (en) A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis (nl) A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis (ast)
author	wds:Q28504576-101E3D55-8795-4A5A-8083-D3598F926CBA wds:Q28504576-8A4DF7AA-D71C-408B-9E72-CB63AB6E2B4F wds:Q28504576-FF35F431-66CC-4819-A263-4D3BB9F130FD
author	Grahame Hardie Mhairi C Towler David Martin
title	wds:Q28504576-7236D4C3-84EC-4AA1-9DB2-2A06E5D08FE5
title	A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis (en)
page(s)	wds:Q28504576-F823223E-13F2-48D4-8F85-5F0D4FFEB0A6
page(s)	1-14
instance of	wds:Q28504576-AF01FE5D-B5F5-46EC-8785-CDE9E7A7AC93
instance of	scholarly article
PubMed ID	wds:Q28504576-4891695B-EE18-4E58-B496-E1DEEBD5057C
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18774945
PubMed ID	18774945
published in	wds:Q28504576-90D7D740-545E-40A6-89D0-4E2C57EEED5E
published in	Biochemical Journal
issue	wds:Q28504576-B2742CCB-944F-4CC1-B439-30FAAEBD67D0
volume	wds:Q28504576-CD471E57-193A-4FCB-A038-49972F095ACD
issue	1
volume	416
DOI	wds:Q28504576-8676DCBB-FC33-4443-BFBC-BAF02F3BCFD5
DOI	http://dx.doi.org/10.1042/BJ20081447
DOI	10.1042/BJ20081447
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q28504576
is cites work of	Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP. Characterization of an alternative splice variant of LKB1 Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity LKB1 is an essential regulator of spermatozoa release during spermiation in the mammalian testis LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function Degradation of AMPK by a cancer-specific ubiquitin ligase C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP. Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation AMPK--sensing energy while talking to other signaling pathways Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1. AMP-activated kinase AMPK is expressed in boar spermatozoa and regulates motility LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice A single-nucleotide polymorphism in serine-threonine kinase 11, the gene encoding liver kinase B1, is a risk factor for multiple sclerosis The LKB1 complex-AMPK pathway: the tree that hides the forest Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis Deletion of endothelial cell-specific liver kinase B1 increases angiogenesis and tumor growth via vascular endothelial growth factor AMPK potentiation by LKB1 isoforms Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation LKB1: cancer, polarity, metabolism, and now fertility A novel LKB1 isoform enhances AMPK metabolic activity and displays oncogenic properties. AMP-activated kinase in human spermatozoa: identification, intracellular localization, and key function in the regulation of sperm motility The calcium/CaMKKalpha/beta and the cAMP/PKA pathways are essential upstream regulators of AMPK activity in boar spermatozoa. AMPK up-activation reduces motility and regulates other functions of boar spermatozoa. Central role of 5'-AMP-activated protein kinase in chicken sperm functions.

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