About: ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons

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About: ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons Goto Sponge NotDistinct Permalink

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description	artículu científicu espublizáu en 2013 (ast) vědecký článek publikovaný v roce 2013 (cs) наукова стаття, опублікована в травні 2013 (uk) 2013 թուականի Մայիսին հրատարակուած գիտական յօդուած (hyw) 2013 թվականի մայիսին հրատարակված գիտական հոդված (hy) wetenschappelijk artikel (gepubliceerd op 2013/05/02) (nl) vedecký článok (publikovaný 2013/05/02) (sk) مقالة علمية (نشرت في 2-5-2013) (ar) article scientifique publié en 2013 (fr) scientific journal article (en) im Mai 2013 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q28119120-BE57113F-C19E-4E3D-8CCF-0020872FEC06
publication date	2013-05-02 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28119120-82F2AC92-FD5E-4542-B004-2DDCBF4166F7
language of work or name	English
cites work	wds:Q28119120-006EE085-F40E-4D83-9F95-72FC604294BA wds:Q28119120-08E0F74D-3FC1-4901-A340-7F36F558B667 wds:Q28119120-11545C20-7809-4704-9822-1FFAD97F9481 wds:Q28119120-1CA0C356-61CE-431C-B750-9F51EF8F6A82 wds:Q28119120-24C378F2-BE12-4EC6-93E3-CF30EBCD2DFE wds:Q28119120-2EEDBD24-97D3-4DE1-9EB9-4FC587237AE9 wds:Q28119120-30D005A5-4EBD-4514-BFD6-C49A9632C3BE wds:Q28119120-35D63B61-E488-4382-AB61-DFBA81889066 wds:Q28119120-42019A71-FE9D-4866-BA09-C9BAF17AB97F wds:Q28119120-5AEC13D5-1A38-4DCA-B340-F19202498015 wds:Q28119120-6A032AC0-EB75-4806-A9E7-492B08AE3DF6 wds:Q28119120-6E854477-DD32-42BD-A5D8-1F5783BD6FD3 wds:Q28119120-704D0A9C-5BB7-457E-9731-630CD683DA49 wds:Q28119120-774B9AB7-E265-4365-BCD5-45A8F2C27727 wds:Q28119120-776346AA-2977-4746-A24A-5833DEB64F2D wds:Q28119120-78BD843B-97E3-421B-BB3E-48D4F3E29D9C wds:Q28119120-98944584-FE41-4ABD-A62D-6C46811F33FD wds:Q28119120-9A44E1F9-182F-4C3F-97BB-77118EEBDA0B wds:Q28119120-9BDD0D24-C4EA-4505-B600-FD71334CFD25 wds:Q28119120-ADEE0D2C-E47F-43FA-8610-4AD7AF27DC24 wds:Q28119120-B7F752E6-CDE9-43E0-B231-24702ACF6FEA wds:Q28119120-BC974664-D45E-422B-976D-B3CD4CED7D73 wds:Q28119120-BE701F98-3532-4A55-A70B-F41CCFA47706 wds:Q28119120-CFCC7B18-D772-46DC-A649-A567B3271977 wds:Q28119120-D31E590A-EAAB-4AB1-A297-4A564AF3743F wds:Q28119120-D6DCCE6F-82A0-448E-A078-963BAA9BEC87 wds:Q28119120-DB30767C-BF7C-44EA-8DA6-E59A855D9E82 wds:Q28119120-E168269A-5B8A-4C53-BA41-382FF1896F50 wds:Q28119120-ED80515E-A6DF-403D-9F81-2FD94553F6D0 wds:Q28119120-ED820FD9-89F3-4017-8579-B796B2753684 wds:Q28119120-FF249B8A-9B93-4BD6-9FF0-A0ED854335F0
cites work	α-Synuclein Is Degraded by Both Autophagy and the Proteasome PARK9-LINKED PARKINSONISM IN EASTERN ASIA: MUTATION DETECTION IN ATP13A2 AND CLINICAL PHENOTYPE Parkinson's disease: from monogenic forms to genetic susceptibility factors Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. Generation of medaka gene knockout models by target-selected mutagenesis ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease Early-onset L-dopa-responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity Alpha-synuclein in Lewy bodies Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity Novel ATP13A2 (PARK9) homozygous mutation in a family with marked phenotype variability Proteasome inhibition in medaka brain induces the features of Parkinson's disease Parkin is recruited selectively to impaired mitochondria and promotes their autophagy Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease Update on the genetics of Parkinson's disease Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration. Common pathogenic effects of missense mutations in the P-type ATPase ATP13A2 (PARK9) associated with early-onset parkinsonism The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival. Regulation of intracellular manganese homeostasis by Kufor-Rakeb syndrome-associated ATP13A2 protein Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish Cathepsin D deficiency is associated with a human neurodegenerative disorder Mutation of the glycosylated asparagine residue 286 in human CLN2 protein results in loss of enzymatic activity. Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants Novel mutation and the first prenatal screening of cathepsin D deficiency (CLN10). Fabry's disease without angiokeratomas showing unusual eccrine gland vacuolation Loss of PINK1 in medaka fish (Oryzias latipes) causes late-onset decrease in spontaneous movement Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson's disease-like phenotypes in medaka fish
author name string	wds:Q28119120-21EEAD65-8921-41B9-9473-010EEF95FF00 wds:Q28119120-27C753FE-C9FD-44EE-995A-0A51048648A3 wds:Q28119120-41FA7370-8913-4B81-BA7E-4E0F1D7A8742 wds:Q28119120-552ADA6B-C2E9-4135-B997-313EFE793DBA wds:Q28119120-7430A1FA-4B6B-434B-A5B4-B07419F68A43 wds:Q28119120-84D2F318-947E-4499-ACE4-9C175AD74B73 wds:Q28119120-879D9D75-9B61-40E4-AEF9-42DDDE234CC4 wds:Q28119120-AA79B343-47FB-4B9F-946E-0B5D52DC1990 wds:Q28119120-D00D4A95-1295-4C78-BF79-A49D3EE3E068 wds:Q28119120-E7F2378B-403B-4525-8B69-2C3CD0AB35AF wds:Q28119120-ED27D35B-2D0E-48D2-8D1A-B4C6996C7436
author name string	Atsushi Toyoda Yoshiyuki Sakaki Yasuo Uchiyama Ryosuke Takahashi Shigeto Sato Hideaki Matsui Fumiaki Sato Hidefumi Ito Yoshihito Taniguchi Shinji Saiki Yosuke Taruno

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