About: The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane

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About: The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane Goto Sponge NotDistinct Permalink

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description	article scientifique publié en 2016 (fr) 2016 թվականի հունվարին հրատարակված գիտական հոդված (hy) artículu científicu espublizáu en 2016 (ast) 2016 թուականի Յունուարին հրատարակուած գիտական յօդուած (hyw) vědecký článek publikovaný v roce 2016 (cs) наукова стаття, опублікована в січні 2016 (uk) مقالة علمية (نشرت عام 2016) (ar) vedecký článok (publikovaný 2016/01/01) (sk) wetenschappelijk artikel (gepubliceerd op 2016/01/01) (nl) 2016 ജനുവരി 1 നു പ്രസിദ്ധീകരിച്ച ശാസ്ത്ര ലേഖനം (ml) im Januar 2016 veröffentlichter wissenschaftlicher Artikel (de) scientific journal article (en)
publication date	wds:Q28116273-BAC637E8-1674-49EE-8849-476907FDF6AA
publication date	2016-01-01 00:00:00Z (xsd:dateTime)
cites work	wds:Q28116273-061521AC-8996-4BBD-B4A2-95A46A29E125 wds:Q28116273-0A2D70AE-4AE5-431F-AF79-57FCFB2A1960 wds:Q28116273-14457091-1513-4D48-9121-8BE413F41B55 wds:Q28116273-1929AB7D-94ED-434B-85A0-F26529AE3AB2 wds:Q28116273-1F5E0334-A95C-493D-8AB8-AA62D708C2D6 wds:Q28116273-2AA31881-D89B-4DED-AA97-DEBE8D65F1A0 wds:Q28116273-2DAE025D-97F3-42C9-B7CC-1C50083620CB wds:Q28116273-2E8D7004-F859-4A36-A701-271ED53D09C9 wds:Q28116273-3A4DE9DF-3EB8-404D-883D-37955AE21E97 wds:Q28116273-3A57D707-54EC-4449-BA7C-02A48AB262FA wds:Q28116273-44AA46E5-E1D2-49F6-9135-9E4779B8282A wds:Q28116273-455C5C1D-E90F-4468-82C4-C7C1212723D4 wds:Q28116273-45A61E53-8D3C-4E43-846A-6040442A06A8 wds:Q28116273-49F0DA3A-A325-4D5B-AF6F-B0DE3BF0937B wds:Q28116273-52FE40CC-BC5B-45F7-8CC5-8713995A7D6C wds:Q28116273-54487341-251C-4130-A173-DF27493BD7A9 wds:Q28116273-5ED34776-10D1-4378-B005-9D4A4FDBD914 wds:Q28116273-5FEC5FBF-3568-46E3-81BC-BC933D4EB635 wds:Q28116273-60980792-25CD-4375-8DC4-6332C0107A42 wds:Q28116273-649F2B42-A419-487B-A8C2-BEC896700745 wds:Q28116273-7C4BF5DA-653C-4D8D-B789-36DD7B0F1640 wds:Q28116273-865909EB-263D-431E-BBE3-B9DD16B1877E wds:Q28116273-8DAA292C-9E6E-43F6-9DCA-8496C822C4AA wds:Q28116273-9848E273-7B59-4747-88C3-A5AC418A8714 wds:Q28116273-9BECE0FB-8316-48CD-9B6A-B0F986EFB565 wds:Q28116273-A249D57A-76B9-46F0-9466-7E26ED739C7C wds:Q28116273-A2CBFD6D-549A-4EAC-ADD2-9BEF52F08231 wds:Q28116273-B1EE01AB-4C64-4F4B-9F8B-F8BDE75F300A wds:Q28116273-B313F985-C6B6-48DE-B945-4D7FA0D0D83E wds:Q28116273-BDCC4BB1-687D-483A-83EF-9F6A78B914E5 wds:Q28116273-C0B0CFB6-AE6C-4F02-9E96-0128F9C3808B wds:Q28116273-C0E1FDEA-1332-4AD5-BED2-EE5E644F10DA wds:Q28116273-C3A8D538-EC0C-40AB-A729-D5B62A4ED8F2 wds:Q28116273-D05D7EFC-6CD3-4F5F-953F-546E8433A4E4 wds:Q28116273-D5F7C2D6-60D7-411A-88A0-5847261B9A20 wds:Q28116273-D9DC51F3-34D5-4C2E-B48C-5D9FFC4453AF wds:Q28116273-DA36CC12-52E2-4009-8D79-CFD3503FEEDE wds:Q28116273-E3F594A7-E76B-4036-B99C-57B6659C7E7A wds:Q28116273-F796A084-5BCF-4790-9F16-252041A4A174 wds:Q28116273-F907C26B-0E6D-4DDE-8D86-C84E9D9FD6AD
cites work	Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS Leukodystrophies Central nervous system myelin: structure, synthesis and assembly Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium. Myelin basic protein as a "PI(4,5)P2-modulin": a new biological function for a major central nervous system protein Size, distribution, and number of fibres in the human corpus callosum. Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by beta-catenin Hyccin, the molecule mutated in the leukodystrophy hypomyelination and congenital cataract (HCC), is a neuronal protein The phosphoinositide 3-kinase pathway Remyelination in the CNS: from biology to therapy Phosphoinositides in cell regulation and membrane dynamics Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics Preparation of selenomethionyl proteins for phase determination Extracting gene function from protein-protein interactions using Quantitative BAC InteraCtomics (QUBIC). A genetic screen for aminophospholipid transport mutants identifies the phosphatidylinositol 4-kinase, STT4p, as an essential component in phosphatidylserine metabolism Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination. Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue Remyelination: the true regeneration of the central nervous system. Processing of X-ray diffraction data collected in oscillation mode Coot: model-building tools for molecular graphics PHENIX: building new software for automated crystallographic structure determination PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity Phosphoinositides: tiny lipids with giant impact on cell regulation Andromeda: a peptide search engine integrated into the MaxQuant environment Myelin basic protein-dependent plasma membrane reorganization in the formation of myelin PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity Myelin regeneration: a recapitulation of development? Deficiency of hyccin, a newly identified membrane protein, causes hypomyelination and congenital cataract [28] Phase determination from multiwavelength anomalous diffraction measurements Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade A plasma membrane pool of phosphatidylinositol 4-phosphate is generated by phosphatidylinositol 4-kinase type-III alpha: studies with the PH domains of the oxysterol binding protein and FAPP1. Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3. PI4KIIIα is required for cortical integrity and cell polarity during Drosophila oogenesis. Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels. Cinderella story: PI4P goes from precursor to key signaling molecule Phenotypic characterization of hypomyelination and congenital cataract. Structural Insights into Assembly and Regulation of the Plasma Membrane Phosphatidylinositol 4-Kinase Complex Diameter of axons and thickness of myelin sheaths of the pyramidal tract fibres in the adult human medullary pyramid. Hypomyelination and congenital cataract: broadening the clinical phenotype Novel FAM126A mutations in hypomyelination and congenital cataract disease
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