About: Alpha-L-iduronidase

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Alpha-L-iduronidase Goto Sponge NotDistinct Permalink

An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

mouse protein (annotated by UniProtKB/Swiss-Prot P48441)

Attributes	Values
rdf:type	Item
description	proteïne (nl) proteinë (sq) بروتين في فأر المنازل (ar) mouse protein (annotated by UniProtKB/Swiss-Prot P48441) (en)
rdfs:label	Alpha-L-iduronidase (en)
skos:prefLabel	Alpha-L-iduronidase (en)
name	Alpha-L-iduronidase (en)
instance of	wds:Q21496504-F1CE0C32-B6A9-4E74-8686-1072EB0F98E7
part of	wds:Q21496504-291FAAD0-5F13-48DC-8648-2D9B42CB5165 wds:Q21496504-C71DD27B-D4E6-4598-8D12-0B72FFACE184 wds:Q21496504-E71CA9C6-2569-4738-B881-60FB620A537A
instance of	protein
part of	glycoside hydrolase superfamily Immunoglobulin-like fold Glycoside hydrolase, family 39
found in taxon	wds:Q21496504-41AA9132-2464-486B-91B4-781AB37C569E
found in taxon	house mouse
molecular function	wds:Q21496504-03D8BC5A-74AD-4DE2-954E-D501ADA2A694 wds:Q21496504-26192445-4CE3-4FF0-9DA7-7834E9BC085C wds:Q21496504-29107A27-3DF4-48F3-81AB-FCFC19467DA0 wds:Q21496504-68895B7B-9050-475F-B926-07398A54EB03 wds:Q21496504-7FA957DC-02FD-4702-8858-5F3B24892A2B wds:Q21496504-A03DEAA6-C791-40F1-982D-3796E877DB07
molecular function	hydrolase activity signaling receptor binding hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds L-iduronidase activity
cell component	wds:Q21496504-B2B0B583-5CDD-48CE-8102-998A3CDDAEF0 wds:Q21496504-C53A6769-8A37-4F43-ACC2-22737D0AF006 wds:Q21496504-D788E29B-0E48-419C-BE26-B31714DC48B7
cell component	extracellular space lysosome coated vesicle
UniProt protein ID	wds:Q21496504-2FBD915D-D617-4201-8C4A-7569195912CF
biological process	wds:Q21496504-0BB2C6E6-0F9F-4BF6-9A39-CBA67A45A650 wds:Q21496504-15D0ADD0-05D6-487B-A3F5-CA861FE132C0 wds:Q21496504-1EAA706F-5C19-45C5-AE66-957DEB2F98ED wds:Q21496504-22CB651E-ACE6-4A49-8818-985ACD743F43 wds:Q21496504-2EB15D4B-7D8B-4307-9771-6957F6DCE6DB wds:Q21496504-3434CC43-8884-4852-B1C8-45FE9E8A0FBB wds:Q21496504-3A63F6EF-D672-4933-A84A-5A11FB3765C5 wds:Q21496504-49262BD8-281B-48ED-9256-34156398DCF0 wds:Q21496504-4F90DA90-6811-4BEF-B886-EC47635A1DD7 wds:Q21496504-50964B62-DCF2-45D1-B338-00E0FB718ED9 wds:Q21496504-5B661F9C-F82C-419C-BFA9-6A38943B598C wds:Q21496504-6C2AA4C4-A07B-4464-9722-3F07144C6ECD wds:Q21496504-875CA1A6-B7CD-440A-B159-A01AB52AE58A wds:Q21496504-9CC02932-E81E-4DB0-8791-31A8ABE5ED4C wds:Q21496504-A6EBBF27-5D95-4316-A1EA-1F2FC3D01D2C wds:Q21496504-A78A3515-2F5F-4CC6-AF73-1BDFB1330480 wds:Q21496504-AC222A2D-AE1C-4AF3-B527-A8F64AE13ADA wds:Q21496504-AE2ED2C3-A1FA-471C-AF1E-FBA952516292 wds:Q21496504-AE708250-833E-4C64-BDBD-D293C60D6DA9 wds:Q21496504-CB871FB9-A94D-4C0D-946A-CD11B0307033 wds:Q21496504-CBCBE514-BC3A-4E23-9635-D85A0AE40431 wds:Q21496504-DBFEB546-AC1D-4963-B738-1B393FD1E471 wds:Q21496504-DFF9A6CE-95C1-49E2-8BF2-8F525C805560 wds:Q21496504-EB9E5520-66E0-4F13-9435-BACC886A881C wds:Q21496504-F7BD1F97-7733-4BCF-BC4B-2714F7DBB2C3
encoded by	wds:Q21496504-EE71CB9B-B4BD-46FE-8504-22105FF65571
UniProt protein ID	uniprot:uniprot/P48441
UniProt protein ID	P48441
biological process	metabolism visual learning memory adult locomotory behavior extracellular matrix organization carbohydrate metabolic process negative regulation of cartilage development cell morphogenesis glycosaminoglycan catabolic process adult walking behavior skeletal system morphogenesis locomotory behavior bone development positive regulation of bone resorption limb morphogenesis lysosome organization chemical homeostasis negative regulation of secretion of lysosomal enzymes dermatan sulfate catabolic process cartilage homeostasis heparin catabolic process positive regulation of collagen catabolic process
encoded by	Idua
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q21496504
is main subject of	Murine mucopolysaccharidosis type I: targeted disruption of the murine alpha-L-iduronidase gene Mucopolysaccharidosis type I, unique structure of accumulated heparan sulfate and increased N-sulfotransferase activity in mice lacking α-l-iduronidase. Evidence of a progressive motor dysfunction in Mucopolysaccharidosis type I mice Progression of multiple behavioral deficits with various ages of onset in a murine model of Hurler syndrome. Effect of neonatal administration of a retroviral vector expressing alpha-L-iduronidase upon lysosomal storage in brain and other organs in mucopolysaccharidosis I mice Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation. Glycosaminoglycan-mediated loss of cathepsin K collagenolytic activity in MPS I contributes to osteoclast and growth plate abnormalities Extracellular matrix disruption is an early event in the pathogenesis of skeletal disease in mucopolysaccharidosis I.
is main subject of	wds:Q28504642-D27F8B79-AEB1-438C-B353-C9509D3D015A wds:Q30452225-FD1500C5-7B5A-44B1-AFF9-5C149C6A0E11 wds:Q37413691-7A12FDD6-3CA6-4132-AD2C-C18ED10942B7 wds:Q45170206-B025B1D5-4CC0-4C4E-B03E-EA64F7D2DEDA

Faceted Search & Find service v1.16.117 as of May 05 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of May 5 2024, on Linux (x86_64-centos_6-linux-gnu), Single-Server Edition (378 GB total memory, 196 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software