About: apoptotic signaling pathway

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A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.

Attributes	Values
rdf:type	Item
description	biologisch proces (nl) біологічний процес (uk) A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. (en)
exact match	wds:Q14866112-48BC6DFE-F91E-4426-AD33-D828AFC01353
exact match	http://purl.obolibrary.org/obo/GO_0097190
rdfs:label	apoptotic signaling pathway (en) apoptotska signalna pot (sl)
skos:prefLabel	apoptotic signaling pathway (en) apoptotska signalna pot (sl)
name	apoptotic signaling pathway (en) apoptotska signalna pot (sl)
Gene Ontology ID	wds:Q14866112-49A3EC63-9961-479A-924E-8EFDBEF729E5
Gene Ontology ID	GO:0097190
instance of	wds:Q14866112-2F772E39-BC8C-415B-8202-534876B6CA15 wds:Q14866112-84fb87b7-4697-842a-0b00-fac659ce76ba
part of	wds:Q14866112-15DB24A1-AB6F-44E4-B250-52181777A7C6
instance of	biological pathway biological process
part of	apoptotic process
subclass of	wds:Q14866112-73CF3D6D-D976-48CF-9795-CFA157F52ADC
subclass of	signal transduction
skos:altLabel	GO:0097190 (en) apoptotic signalling pathway (en) induction of apoptosis by extracellular signals (en)
UMLS CUI	wds:Q14866112-05063DD2-654C-47D1-9AA2-419FDDEC6635
UMLS CUI	C3269135
Pathway Ontology ID	wds:Q14866112-a2492644-4224-8a70-3ee4-d5f5bad54d31
Pathway Ontology ID	PW:0000009
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q14866112
is instance of of	FasL/ CD95L signaling Caspase-8 processing within TLR4 complex Caspase-8 processing within TLR3 complex Ceramide signalling FASL binds FAS Receptor Cell death signalling via NRAGE, NRIF and NADE
is part of of	release of cytochrome c from mitochondria cysteine-type endopeptidase activity involved in apoptotic signaling pathway mitochondrial outer membrane permeabilization apoptosome assembly
is instance of of	wds:Q50299334-B9D887F9-BB30-4F46-AB89-6159E61756E9 wds:Q50291745-F2D1081B-B0F8-4F09-8986-C84E14C0429F wds:Q45318027-B009CBE3-4809-4F24-8F54-D3DEFD751CB6 wds:Q45318341-F436C9A0-73DF-43BD-9A29-815BB35A89E7 wds:Q50291836-EAE9FEC3-997A-411E-B667-F1058B3FD59B wds:Q45318014-0697DEBD-AF61-47B7-B022-7F9AF2C286A0
is part of of	wds:Q21100275-6268AB22-D602-4EB5-9D8E-1FFA33785C62 wds:Q22295190-F63F7351-8825-4770-85ED-70CA70135C59 wds:Q14818004-729DECDC-3C8D-48AB-9CDA-7E44295F7144 wds:Q21100385-F60C3477-9896-4FDC-9BD7-BAB48830C429
is subclass of of	extrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway hormone-mediated apoptotic signaling pathway granzyme-mediated apoptotic signaling pathway
is subclass of of	wds:Q14903972-0DD91834-1E0D-4179-9679-F3A406DA5FC6 wds:Q14819857-800A9C3D-E78E-4843-9B2C-850B2FCE1D78 wds:Q14818093-4ABABB45-58CA-4AB1-A88C-FC21DF4678B4 wds:Q21106191-6C0D3AB0-412C-4050-8CDD-051C849C23B0
is main subject of	Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule Interaction of two classes of ADP-ribose transfer reactions in immune signaling RAIDD is a new 'death' adaptor molecule MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3 Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells Adenosine stimulates DNA fragmentation in human thymocytes by Ca(2+)-mediated mechanisms Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB Bryostatin 1 induces prolonged activation of extracellular regulated protein kinases in and apoptosis of LNCaP human prostate cancer cells overexpressing protein kinase calpha The endoplasmic reticulum is a key component of the plasma cell death pathway Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4 Requiem: a novel zinc finger gene essential for apoptosis in myeloid cells Effect of antibodies to rat and human cerebral cortex and white matter on heterologous T- and B-cells
is main subject of	wds:Q24306814-BB6F7BC4-FBC2-496F-ABB4-8775217FA610 wds:Q24298224-3F6A2B60-1F72-40DC-B110-55EC982E6005 wds:Q24310279-D01B743F-0E51-49C1-84D6-64EEC6BEF571 wds:Q22009525-3267C6D7-B733-42BA-9A46-A6FBD670C3D0 wds:Q24312205-3AD16C66-5C5D-4C1A-B007-5ABABCE0D7AC wds:Q24304292-B2A6390D-7602-447F-BEB0-50086F74084A wds:Q24308748-4B5900BC-0614-4158-8D0D-62E5D0ADD00F wds:Q22254131-B36B0CC5-02B4-46C6-AEA1-813F9FD40CC6 wds:Q24301496-9A88E475-EED1-4024-8B89-2A0B915342FE wds:Q24302494-22BFF55C-B087-456C-ADC4-21C0547B569F wds:Q24337199-005387BD-FAF5-4382-9E4E-7C8E72366465 wds:Q24317030-C9D0D0B7-4FD7-42EC-BDE6-61EDE631A223 wds:Q24309288-60D0BE94-0298-434D-B694-9FD43DC964A0 wds:Q24294909-AEB1CD43-C9F1-4F11-B07F-15DBA2BE7104 wds:Q24290333-68D0A53A-0195-4918-B7E6-53B0E9604396 wds:Q24309037-76A1A3DD-D5C6-4124-8EA2-D2B8247BC72B wds:Q22254731-8FFBD319-1FE8-45A7-B288-572F08E8313F wds:Q24290576-4842352D-2EA9-4E13-8EB3-61394751F9BA

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