About: Virginia C. Broudy

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An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

American oncologist

Attributes	Values
rdf:type	Item
description	American oncologist (en) طبيبة أورام أمريكية (ar) oncóloga estadounidense (es)
rdfs:label	Virginia C. Broudy (en)
skos:prefLabel	Virginia C. Broudy (en)
name	Virginia C. Broudy (en)
given name	wds:Q116764538-8357815a-4dc7-2308-386d-f5e840098ad2
given name	Virginia
instance of	wds:Q116764538-c5d424a0-47d7-371f-f125-12b85304bdc9
instance of	Homo sapiens
skos:altLabel	V. C. Broudy (en) Virginia Broudy (en)
occupation	wds:Q116764538-24abb7bd-4cd5-7f29-2a31-8e1c00bf3eb4 wds:Q116764538-bece4a6d-4b6d-b82a-e21d-fe1b133835f0
employer	wds:Q116764538-3eab395e-4bd0-fd24-10ed-73e7b40f026b wds:Q116764538-69e3a909-40cb-6bf3-4f6b-1a29842b1340 wds:Q116764538-81dc69c5-4ceb-205c-4af4-fef564146fda wds:Q116764538-bff43ee6-4b24-754d-72a4-4145ef1340e3
sex or gender	wds:Q116764538-16446320-4fbf-db59-6d30-c4db2b2fefdc
country of citizenship	wds:Q116764538-b438e7ce-4a0b-703c-a1e4-626c058c828f
educated at	wds:Q116764538-5b8fc9c9-4cd8-c4ef-a6ae-b21ab6583702 wds:Q116764538-e33f0af9-45a3-1894-9aee-6ab4c5e3d884
family name	wds:Q116764538-e130315e-4144-2e78-ab6d-d733154f4c8c
occupation	oncologist hematologist
employer	Harborview Medical Center University of Washington Oregon Health & Science University UW Medicine
sex or gender	female organism
country of citizenship	United States of America
educated at	Harvard College University of California, San Francisco
family name	Broudy
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q116764538
is author of	Interaction of stem cell factor and its receptor c-kit mediates lodgment and acute expansion of hematopoietic cells in the murine spleen Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy Signaling via Src family kinases is required for normal internalization of the receptor c-Kit Blasts from patients with acute myelogenous leukemia express functional receptors for stem cell factor Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice Isolation of c-kit receptor-expressing cells from bone marrow, peripheral blood, and fetal liver: functional properties and composite antigenic profile Stem cell factor and hematopoiesis Familial and congenital polycythemia in three unrelated families Interaction of human bone marrow fibroblasts with megakaryocytes: role of the c-kit ligand Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding. Tumor necrosis factor-alpha and tumor necrosis factor-beta (lymphotoxin) stimulate the production of granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and IL-1 in vivo Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development Human umbilical vein endothelial cells display high-affinity c-kit receptors and produce a soluble form of the c-kit receptor Adult scurvy Human platelets display high-affinity receptors for thrombopoietin Analysis of c-kit receptor dimerization by fluorescence resonance energy transfer FLT3 receptor expression on the surface of normal and malignant human hematopoietic cells AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl. The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit Stem cell factor modulates avidity of alpha 4 beta 1 and alpha 5 beta 1 integrins expressed on hematopoietic cell lines. Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice The fifth immunoglobulin-like domain of the Kit receptor is required for proteolytic cleavage from the cell surface Soluble kit receptor in human serum. Monocytes stimulate fibroblastoid bone marrow stromal cells to produce multilineage hematopoietic growth factors Interferon-alpha treatment of posttransplant lymphoproliferative disorder in recipients of solid organ transplants Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors Identification of the receptor for erythropoietin on human and murine erythroleukemia cells and modulation by phorbol ester and dimethyl sulfoxide Epitope mapping and functional studies with three monoclonal antibodies to the c-kit receptor tyrosine kinase, YB5.B8, 17F11, and SR-1. Isolation and characterization of a monoclonal antibody that recognizes the human c-kit receptor Internalization of the thrombopoietin receptor is regulated by 2 cytoplasmic motifs Disparate effects of tumor necrosis factor-alpha/cachectin and tumor necrosis factor-beta/lymphotoxin on hematopoietic growth factor production and neutrophil adhesion molecule expression by cultured human endothelial cells Interleukin 1 stimulates human endothelial cells to produce granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor Soluble Kit receptor blocks stem cell factor bioactivity in vitro Evaluation of the impact of HIV serostatus, tobacco smoking and CD4 counts on epidermoid anal cancer survival. Erythropoietin receptor characteristics on primary human erythroid cells Dynamics of erythropoietin receptor expression on erythropoietin-responsive murine cell lines Stem cell factor production by human marrow stromal fibroblasts Abnormal response to granulocyte colony-stimulating factor (G-CSF) in canine cyclic hematopoiesis is not caused by altered G-CSF receptor expression Muramyl dipeptide induces production of hemopoietic growth factors in vivo by a mechanism independent of tumor necrosis factor Teaching hematology to second year medical students: results of a national survey of hematology course directors. Preclinical Medical Student Hematology/Oncology Education Environment. Structure-function relationships of interleukin-3. An analysis based on the function and binding characteristics of a series of interspecies chimera of gibbon and murine interleukin-3 Recombinant human erythropoietin: purification and analysis of carbohydrate linkage Further phenotypic characterization and isolation of human hematopoietic progenitor cells using a monoclonal antibody to the c-kit receptor Cytogenetic evidence for involvement of B lymphocytes in acquired idiopathic sideroblastic anemias Membrane localization is not required for Mpl function in normal hematopoietic cells The recipient origin of posttransplant lymphoproliferative disorders in pulmonary transplant patients. A report of three cases Thrombopoietin, the c-mpl ligand, is a major regulator of platelet production Successful nonmyeloablative allogeneic hematopoietic stem cell transplant in an acute leukemia patient with chemotherapy-induced marrow aplasia and progressive pulmonary aspergillosis Mast cell growth factor (c-kit ligand) restores growth of multipotent progenitors in myelodysplastic syndrome Identification and characterization of an isoform of murine Mpl. Biology of thrombopoietin. Selection of lineage-restricted cell lines immortalized at different stages of hematopoietic differentiation from the murine cell line 32 D Characterization of the structure of the erythropoietin receptor by ligand blotting Effect of stem cell factor on myelopoiesis potential in human Dexter-type culture systems Tyrosine 462 of the membrane-proximal F'-G' loop of murine Mpl is not essential for high-affinity binding of thrombopoietin Stem cell factor influences the proliferation and erythroid differentiation of the MB-02 human erythroleukemia cell line by binding to a high-affinity c-kit receptor. Neutralization of stem cell factor in vitro and in vivo: dose-dependent inhibition of stromal cells and induction of granulocyte/monocyte differentiation

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