About: Tiacumicins, a novel complex of 18-membered macrolide antibiotics. I. Taxonomy, fermentation and antibacterial activity.

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About: Tiacumicins, a novel complex of 18-membered macrolide antibiotics. I. Taxonomy, fermentation and antibacterial activity. Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Item
description	article scientifique publié en 2012 (fr)
publication date	wds:Q105022846-132E943A-D44E-465A-B081-34C45A1FFA83
publication date	1987-01-01 00:00:00Z (xsd:dateTime)
access restriction status	wds:Q105022846-28DDA3CC-1C16-4B43-951F-8D524ABF6475
access restriction status	open access
author name string	wds:Q105022846-39B5C9EE-C9E4-4038-AE7A-04A83B6CB5D1 wds:Q105022846-43A9E114-A2AC-4F6B-A8B6-25BC57250AC6 wds:Q105022846-9D30A306-8BB2-410A-9FB1-E44768FDFB27 wds:Q105022846-B59F4021-4B46-433D-9463-B35B553F6E5C wds:Q105022846-C6945E75-326E-4312-BF57-8C15E7BC87D3 wds:Q105022846-E18FCB4B-FA25-4606-BADF-054A1A7D2D36 wds:Q105022846-FFCAE66C-270C-4805-91BA-F86108997287
author name string	JAMES P. KARWOWSKI MARIANNA JACKSON CHARLENE M. VOJTKO GABRIELA N. SUNGA LYLE J. COEN ROBERT J. THERIAULT ROLAND L. GIROLAMI
rdfs:label	Tiacumicins, a novel complex of 18-membered macrolide antibiotics. I. Taxonomy, fermentation and antibacterial activity. (en)
skos:prefLabel	Tiacumicins, a novel complex of 18-membered macrolide antibiotics. I. Taxonomy, fermentation and antibacterial activity. (en)
name	Tiacumicins, a novel complex of 18-membered macrolide antibiotics. I. Taxonomy, fermentation and antibacterial activity. (en)
title	wds:Q105022846-EDF75BB4-4567-477F-8479-B05D38A0B4C2
title	Tiacumicins, a novel complex of 18-membered macrolide antibiotics. I. Taxonomy, fermentation and antibacterial activity. (en)
page(s)	wds:Q105022846-A8989A4F-9F55-41B5-950D-22CE4466A53D
page(s)	567-574
instance of	wds:Q105022846-1D7EA0E1-249C-4889-BBB7-B79A9F7781B6
instance of	scholarly article
main subject	wds:Q105022846-0CAE7A36-CCBA-41A8-8932-DD04D6574873 wds:Q105022846-2A097895-27F3-4407-92AE-8D112B53504F wds:Q105022846-625273A4-DF75-4918-83DB-CBACE826B3CC wds:Q105022846-7F2AEF2A-FBBC-47F4-88D3-324AE7A852F8 wds:Q105022846-B03F01D0-6A12-4D49-A4E8-D23DD3F5AD78 wds:Q105022846-C755E141-45ED-43FA-AE4E-79C2B2023287 wds:Q105022846-F302EE66-1123-40FD-B245-09229568C528
main subject	Dactylosporangium aurantiacum GWWZJUQHOUTOLT-UHFFFAOYSA-N OXDCGWNHLLQECN-UHFFFAOYSA-N Clostomicin A VYHICDMNVHVXOH-JCXAYPELSA-N fidaxomicin Tiacumicin A
published in	wds:Q105022846-67287F81-386E-4D4D-A5FA-8B02BF7212FE
full work available at URL	wds:Q105022846-3106309D-550F-46A8-8241-D062785A1382
published in	The Journal of Antibiotics
full work available at URL	https://www.jstage.jst.go.jp/article/antibiotics1968/40/5/40_5_567/_pdf
issue	wds:Q105022846-497BB0E3-0A0F-4055-B79D-EC74E01E7A1B
volume	wds:Q105022846-1661041E-801A-45DB-9B27-E29112250F63
issue	5
volume	40
DOI	wds:Q105022846-3F642E50-9951-4D4F-8B61-6633F1756FB9
DOI	http://dx.doi.org/10.7164/ANTIBIOTICS.40.567
DOI	10.7164/ANTIBIOTICS.40.567
online access status	wds:Q105022846-BA332F7E-9BCE-49EF-AC65-1882AF50177E
online access status	open access
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q105022846
is cites work of	Antimicrobial activities of fidaxomicin Recent developments in antibacterial drug discovery: microbe-derived natural products--from collection to the clinic Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species Clinical outcomes, safety, and pharmacokinetics of OPT-80 in a phase 2 trial with patients with Clostridium difficile infection Antibiotics in the clinical pipeline in 2013. Fidaxomicin: a novel macrocyclic antibiotic for the treatment of Clostridium difficile infection New target for inhibition of bacterial RNA polymerase: 'switch region' In vitro and in vivo evaluation of tiacumicins B and C against Clostridium difficile In vitro activity of OPT-80 against Clostridium difficile Fidaxomicin (OPT-80) for the treatment of Clostridium difficile infection Fidaxomicin: first-in-class macrocyclic antibiotic OPT-80, a macrocyclic antimicrobial agent for the treatment of Clostridium difficile infections: a review From natural product to marketed drug: the tiacumicin odyssey Natural products--the future scaffolds for novel antibiotics? In vitro activities of OPT-80 and comparator drugs against intestinal bacteria Fidaxomicin: a novel macrocyclic antibiotic approved for treatment of Clostridium difficile infection Detection of novel secondary metabolites. Fidaxomicin: a review of its use in patients with Clostridium difficile infection OPT-80 eliminates Clostridium difficile and is sparing of bacteroides species during treatment of C. difficile infection Fidaxomicin in Clostridium difficile infection: latest evidence and clinical guidance Safety, tolerance, and pharmacokinetic studies of OPT-80 in healthy volunteers following single and multiple oral doses Screening strategies for discovery of antibacterial natural products Antibiotics in the clinical pipeline in 2011. Detection, selective isolation and characterisation of Dactylosporangium strains from diverse environmental samples. Fidaxomicin: a macrocyclic antibiotic for the management of Clostridium difficile infection In vitro activity of OPT-80 tested against clinical isolates of toxin-producing Clostridium difficile Total synthesis of the tiacumicin B (lipiarmycin A3/fidaxomicin) aglycone Retrospective analysis of natural products provides insights for future discovery trends Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3). Actinomycetes: still a source of novel antibiotics Semisynthetic Analogs of the Antibiotic Fidaxomicin-Design, Synthesis, and Biological Evaluation Mother Nature's gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discovery. Fidaxomicin--the new drug for Clostridium difficile infection Astonishing diversity of natural surfactants: 2. Polyether glycosidic ionophores and macrocyclic glycosides Fidaxomicin: in Clostridium difficile infection The Family Micromonosporaceae Terrestrial Microorganisms – Filamentous Bacteria The ups and downs of drug discovery: the early history of Fidaxomicin. Total Synthesis of Tiacumicin A. Total Synthesis, Relay Synthesis, and Degradation Studies of Fidaxomicin (Tiacumicin B, Lipiarmycin A3) New agents for Clostridium difficile-associated disease Enantioselective synthesis of putative lipiarmycin aglycon related to fidaxomicin/tiacumicin B A method for the selective isolation of Myxococcus directly from soil

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